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Prolonged nicotine exposure does not alter gaba(b) receptor-mediated regulation of brain reward function

Academic Article
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Overview

authors

  • Paterson, N. E.
  • Bruijnzeel, A. W.
  • Kenny, Paul
  • Wright, C. D.
  • Froestl, W.
  • Markou, A.

publication date

  • December 2005

journal

  • Neuropharmacology  Journal

abstract

  • Gamma-aminobutyric acid subtype B (GABA(B)) receptors play an important role in regulating brain reward function. Accumulating evidence suggests that chronic exposure to drugs of abuse may alter GABA(B) receptor function. The present studies investigated whether chronic nicotine administration, using a regimen that induces nicotine dependence, increased inhibitory regulation of brain reward function by GABA(B) receptors, as measured by intracranial self-stimulation (ICSS) thresholds in rats. Such an action of nicotine may contribute to the reward deficit observed during nicotine withdrawal. Nicotine-dependent and control rats received the GABA transaminase inhibitor gamma-vinyl-GABA or the GABA(B) receptor agonist CGP44532 according to a within-subjects Latin square design, and ICSS thresholds were assessed post-injection. Systemic administration of the lowest doses of GVG or CGP44532 did not alter reward thresholds in control or nicotine-treated rats, whereas the highest doses of each drug elevated thresholds similarly in both groups. Further, micro-infusion of CGP44532 directly into the ventral tegmental area elevated ICSS thresholds similarly in saline- and nicotine-treated rats. Overall, these data demonstrate that prolonged nicotine exposure did not alter GABA(B) receptor-mediated regulation of brain reward function, and suggest that alterations in GABA(B) receptor activity are unlikely to play a role in the brain reward deficits associated with spontaneous nicotine withdrawal.

subject areas

  • 4-Aminobutyrate Transaminase
  • Animals
  • Brain
  • Dopamine
  • Electrodes, Implanted
  • Enzyme Inhibitors
  • GABA Agonists
  • GABA-B Receptor Agonists
  • Limbic System
  • Male
  • Nicotine
  • Nicotinic Agonists
  • Rats
  • Rats, Wistar
  • Receptors, GABA-B
  • Reward
  • Self Stimulation
  • Synaptic Transmission
  • Ventral Tegmental Area
  • Vigabatrin
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Research

keywords

  • CGP44532
  • GABA(B) receptors
  • GVG
  • chronic nicotine
  • dependence
  • intracranial self-stimulation
  • rat
  • reward
  • ventral tegmental area
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Identity

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/j.neuropharm.2005.04.031

PubMed ID

  • 16005474
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Additional Document Info

start page

  • 953

end page

  • 962

volume

  • 49

issue

  • 7

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