recent publications

• academic article

  • Repunte-Canonigo, V., Lefebvre, C., George, O., Kawamura, T., Morales, M., Koob, G. F., Califano, A., Masliah, E., Sanna, P. P. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats Molecular Neurodegeneration  2014 9:26  DOI:10.1186/1750-1326-9-26  PMID:24980976  PMCID:PMC4107468
  • Roth, D. M., Hutt, D. M., Tong, J., Bouchecareilh, M., Wang, N., Seeley, T., Dekkers, J. F., Beekman, J. M., Garza, D., Drew, L., Masliah, E., Morimoto, R. I., et al. Modulation of the maladaptive stress response to manage diseases of protein folding PLoS Biology  2014 12  DOI:10.1371/journal.pbio.1001998  PMID:25406061  PMCID:PMC4236052
  • Blurton-Jones, M., Spencer, B., Michael, S., Castello, N. A., Agazaryan, A. A., Davis, J. L., Muller, F. J., Loring, J. F., Masliah, E., LaFerla, F. M. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models Stem Cell Research & Therapy  2014 5:46  DOI:10.1186/scrt440  PMID:25022790  PMCID:PMC4055090
  • Huang, T. Y., Michael, S., Xu, T., Sarkeshik, A., Moresco, J. J., Yates, J. R., 3rd, Masliah, E., Bokoch, G. M., DerMardirossian, C. A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation Molecular Biology of the Cell  2013 24:194-209  DOI:10.1091/mbc.E12-07-0565  PMID:23223568  PMCID:PMC3564530
  • Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America  2013 110:E2518-E2527  DOI:10.1073/pnas.1306832110  PMID:23776240  PMCID:PMC3704025
  • Bett, C., Kurt, T. D., Lucero, M., Trejo, M., Rozemuller, A. J., Kong, Q. Z., Nilsson, K. P. R., Masliah, E., Oldstone, M. B., Sigurdson, C. J. Defining the conformational features of anchorless, poorly neuroinvasive prions PLoS Pathogens  2013 9:e1003280  DOI:10.1371/journal.ppat.1003280  PMID:23637596  PMCID:PMC3630170
  • Ryan, S. D., Dolatabadi, N., Chan, S. F., Zhang, X., Akhtar, M. W., Parker, J., Soldner, F., Sunico, C. R., Nagar, S., Talantova, M., Lee, B., Lopez, K., et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 alpha transcription Cell  2013 155:1351-1364  DOI:10.1016/j.cell.2013.11.009  PMID:24290359  PMCID:PMC4028128
  • Bett, C., Joshi-Barr, S., Lucero, M., Trejo, M., Liberski, P., Kelly, J. W., Masliah, E., Sigurdson, C. J. Biochemical properties of highly neuroinvasive prion strains PLoS Pathogens  2012 8:e1002522  DOI:10.1371/journal.ppat.1002522  PMID:22319450  PMCID:PMC3271082
  • Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B., Oldstone, M. B. A. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Proceedings of the National Academy of Sciences of the United States of America  2012 109:13733-13738  DOI:10.1073/pnas.1211499109  PMID:22869751  PMCID:PMC3427069
  • Tang, B., Becanovic, K., Desplats, P. A., Spencer, B., Hill, A. M., Connolly, C., Masliah, E., Leavitt, B. R., Thomas, E. A. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the cns: Implications for transcriptional dysregulation in huntington disease Human Molecular Genetics  2012 21:3097-3111  DOI:10.1093/hmg/dds132  PMID:22492998  PMCID:PMC3384380
  • Li, X. Y., Masliah, E., Reixach, N., Buxbaum, J. N. Neuronal production of transthyretin in human and murine Alzheimer's disease: Is it protective? Journal of Neuroscience  2011 31:12483-12490  DOI:10.1523/jneurosci.2417-11.2011  PMID:21880910  PMCID:PMC3172869
  • Scott, D. A., Tabarean, I., Tang, Y., Cartier, A., Masliah, E., Roy, S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration Journal of Neuroscience  2010 30:8083-8095  DOI:10.1523/jneurosci.1091-10.2010  PMID:20554859  PMCID:PMC2901533
  • Koob, A. O., Ubhi, K., Paulsson, J. F., Kelly, J., Rockenstein, E., Mante, M., Adame, A., Masliah, E. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies Experimental Neurology  2010 221:267-274  DOI:10.1016/j.expneurol.2009.11.015  PMID:19944097  PMCID:PMC2812599
  • Pham, E., Crews, L., Ubhi, K., Hansen, L., Adame, A., Cartier, A., Salmon, D., Galasko, D., Michael, S., Savas, J. N., Yates, J. R., Glabe, C. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins FEBS Journal  2010 277:3051-3067  DOI:10.1111/j.1742-4658.2010.07719.x  PMID:20573181  PMCID:PMC2933033
  • Chu, J., Hong, N. A., Masuda, C. A., Jenkins, B. V., Nelms, K. A., Goodnow, C. C., Glynne, R. J., Wu, H., Masliah, E., Joazeiro, C. A. P., Kay, S. A. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Proceedings of the National Academy of Sciences of the United States of America  2009 106:2097-2103  DOI:10.1073/pnas.0812819106  PMID:19196968  PMCID:PMC2650114
  • Cohen, E., Paulsson, J. F., Blinder, P., Burstyn-Cohen, T., Du, D. G., Estepa, G., Adame, A., Pham, H. M., Holzenberger, M., Kelly, J. W., Masliah, E., Dillin, A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice Cell  2009 139:1157-1169  DOI:10.1016/j.cell.2009.11.014  PMID:20005808  PMCID:PMC3017511
  • Buxbaum, J. N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A. R., Bartfai, T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity Proceedings of the National Academy of Sciences of the United States of America  2008 105:2681-2686  DOI:10.1073/pnas.0712197105  PMID:18272491  PMCID:PMC2268196
  • Trifilo, M. J., Yajima, T., Gu, Y. S., Dalton, N., Peterson, K. L., Race, R. E., Meade-White, K., Portis, J. L., Masliah, E., Knowlton, K. U., Chesebro, B., Oldstone, M. B. A. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice Science  2006 313:94-97  DOI:10.1126/science.1128635  PMID:16825571  PMCID:PMC1820586
  • Chesebro, B., Trifilo, M., Race, R., Meade-White, K., Teng, C., LaCasse, R., Raymond, L., Favara, C., Baron, G., Priola, S., Caughey, B., Masliah, E., et al. Anchorless prion protein results in infectious amyloid disease without clinical scrapie Science  2005 308:1435-1439  DOI:10.1126/science.1110837  PMID:15933194
  • Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo Science  2004 303:1514-1516  DOI:10.1126/science.1094273  PMID:14752167
  • Chismar, J. D., Mondala, T., Fox, H. S., Roberts, E., Langford, D., Masliah, E., Salomon, D. R., Head, S. R. Analysis of result variability from high-density oligonucleotide arrays comparing same-species and cross-species hybridizations Biotechniques  2002 33:516-518, 520, 522 passim  PMID:12238761
  • Gonzalez-Dunia, D., Watanabe, M., Syan, S., Mallory, M., Masliah, E., de la Torre, J. C. Synaptic pathology in Borna disease virus persistent infection Journal of Virology  2000 74:3441-3448  DOI:10.1128/jvi.74.8.3441-3448.2000  PMID:10729116
  • Akwa, Y., Hassett, D. E., Eloranta, M. L., Sandberg, K., Masliah, E., Powell, H., Whitton, J. L., Bloom, F. E., Campbell, I. L. Transgenic expression of ifn-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration Journal of Immunology  1998 161:5016-5026  PMID:9794439
  • Gold, L. H., Heyser, C. J., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice Advances in Experimental Medicine and Biology  1996 402:199-205  DOI:10.1007/978-1-4613-0407-4_26  PMID:8787661
  • DelaTorre, J. C., GonzalezDunia, D., Cubitt, B., Mallory, M., MuellerLantzsch, N., Grasser, F. A., Hansen, L. A., Masliah, E. Detection of borna disease virus antigen and rna in human autopsy brain samples from neuropsychiatric patients Virology  1996 223:272-282  DOI:10.1006/viro.1996.0479  PMID:8806563
  • delaTorre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., Masliah, E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells Virology  1996 220:508-515  DOI:10.1006/viro.1996.0340  PMID:8661403
  • Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B. A., Mucke, L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6 Proceedings of the National Academy of Sciences of the United States of America  1993 90:10061-10065  DOI:10.1073/pnas.90.21.10061  PMID:7694279  PMCID:PMC47713
  • Masliah, E., Mallory, M., Deerinck, T., DeTeresa, R., Lamont, S., Miller, A., Terry, R. D., Carragher, B., Ellisman, M. Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease Journal of Neuropathology and Experimental Neurology  1993 52:619-632  DOI:10.1097/00005072-199311000-00009  PMID:8229081
  • Hessler, D., Young, S. J., Carragher, B. O., Martone, M. E., Lamont, S., Whittaker, M., Milligan, R. A., Masliah, E., Hinshaw, J. E., Ellisman, M. H. Programs for visualization in three-dimensional microscopy Neuroimage  1992 1:55-67  DOI:10.1016/1053-8119(92)90007-A  PMID:9343557
  • Masliah, E., Ellisman, M., Carragher, B., Mallory, M., Young, S., Hansen, L., DeTeresa, R., Terry, R. D. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease Journal of Neuropathology and Experimental Neurology  1992 51:404-414  DOI:10.1097/00005072-199207000-00003  PMID:1619440