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Activation of B lymphocytes by monovalent anti-Lyb-2 antibodies

Academic Article
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Overview

authors

  • Subbarao, B.
  • Mosier, Donald

publication date

  • 1984

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Although activation of B lymphocytes by antigen or anti-Ig antibody has been shown to require cross-linking of surface Ig molecules, cross-linking is not necessary for B cell activation by anti-Lyb-2 monoclonal antibody (MAb). Monovalent Fab' fragments of anti-Lyb-2 MAb are as effective as the intact antibody in inducing blast cell transformation of small B cells and B cell proliferation in the apparent absence of T cells and adherent cells. In the presence of factors from T cells, B cells activated by Fab' fragments of anti-Lyb-2 MAb were induced to mature into Ig-secreting cells. Since monovalent Fab' fragments probably cannot induce receptor aggregation, it appears that receptor occupancy is sufficient to induce B cell activation with anti-Lyb-2 MAb.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Ly
  • Antigens, Surface
  • B-Lymphocytes
  • Cells, Cultured
  • Immunoglobulin Fab Fragments
  • Lymphocyte Activation
  • Macromolecular Substances
  • Mice
  • Mice, Inbred Strains
  • Spleen
  • T-Lymphocytes
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Identity

PubMed Central ID

  • PMC2187309

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.159.6.1796

PubMed ID

  • 6427385
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Additional Document Info

start page

  • 1796

end page

  • 1801

volume

  • 159

issue

  • 6

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