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Indomethacin versus radiation therapy for heterotopic ossification after hip arthroplasty

Academic Article
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Overview

authors

  • D'Lima, Darryl
  • Venn-Watson, E. J.
  • Tripuraneni, P.
  • Colwell Jr., Clifford

publication date

  • 2001

journal

  • Orthopedics  Journal

abstract

  • This study compared the efficacy and cost of radiation therapy with indomethacin in the prophylaxis of heterotopic ossification following total hip replacement. Twenty-two patients received a radiation dose of 10 Gy in five fractions, 28 patients 8 Gy in one fraction, and 27 patients 25 mg oral indomethacin three times a day for either 7 or 21 days. Patients at higher risk for heterotopic ossification were more likely to receive radiation therapy than indomethacin. At a mean follow-up of 2 years, there were no differences in failure rates between the high-risk patients treated with radiation and the low-risk patients treated with indomethacin. Currently, the patient-billed cost of radiation is $1400 whereas the cost for indomethacin is approximately $100. Indomethacin appears to be as effective as radiation therapy in patients at low to moderate risk for heterotopic ossification and offers significant cost savings.

subject areas

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal
  • Arthroplasty, Replacement, Hip
  • Female
  • Health Care Costs
  • Humans
  • Indomethacin
  • Male
  • Middle Aged
  • Ossification, Heterotopic
  • Radiotherapy
  • Retrospective Studies
  • Risk Factors
  • Treatment Failure
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Identity

International Standard Serial Number (ISSN)

  • 0147-7447

PubMed ID

  • 11770090
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Additional Document Info

start page

  • 1139

end page

  • 1143

volume

  • 24

issue

  • 12

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