Biochemistry

articles

Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway. 59:2319-2327. 2020
Programmable One-Pot Synthesis of Oligosaccharides. 59:3078-3088. 2020
A dynamic switch in inactive p38γ leads to an excited state on the pathway to an active kinase. 58:5160-5172. 2019
Structure and dynamics of stacking interactions in an antibody binding site. 58:2987-2995. 2019
Eight-letter DNA. 58:2581-2583. 2019
Structural, kinetic, and mechanistic analysis of an asymmetric 4-oxalocrotonate tautomerase trimer. 58:2617-2627. 2019
Empirical and computational comparison of alternative therapeutic exon skip repairs for duchenne muscular dystrophy. 58:2061-2076. 2019
X-ray structures of two bacteroides thetaiotaomicron C11 proteases in complex with peptide-based inhibitors. 58:1728-1737. 2019
Synthetic epigenetics to engineer regulation. 58:1558-1559. 2019
Role of backbone dynamics in modulating the interactions of disordered ligands with the TAZ1 domain of the CREB-binding protein. 58:1354-1362. 2019
A hidden ORF reveals an immune protector. 58:1022-1023. 2019
Design, validation, and application of an enzyme-coupled hydrogen sulfide detection assay. 58:474-483. 2019
UBC9 mutant reveals the impact of protein dynamics on substrate selectivity and SUMO chain linkages. 58:621-632. 2019
Caught in the Act? Quantifying biochemistry inside and outside of biomolecular condensates. 58:142-143. 2019
Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin. 57:6919-6922. 2018
Structural basis for graded inhibition of CREB:DNA interactions by multi-site phosphorylation. 57:6964-6972. 2018
A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation. 57:6822-6826. 2018
Biochemical characterization and structure-based mutational analysis provide insight into the binding and mechanism of action of novel aspartate aminotransferase inhibitors. 57:6604-6614. 2018
A quantitative model for BicD2/cargo interactions. 57:6538-6550. 2018
The spastic paraplegia-associated phospholipase DDHD1 is a primary brain phosphatidylinositol lipase. 57:5759-5767. 2018
MIEF1 microprotein regulates mitochondrial translation. 57:5564-5575. 2018
P450-catalyzed tailoring steps in leinamycin biosynthesis featuring regio- and stereoselective hydroxylations and substrate promiscuities. 57:5005-5013. 2018
A HaloTag-based multicolor fluorogenic sensor visualizes and quantifies proteome stress in live cells using solvatochromic and molecular rotor-based fluorophores. 57:4663-4674. 2018
NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations. 57:4421-4430. 2018
How do intrinsically disordered viral proteins hijack the cell?. 57:4045-4046. 2018
Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme. 57:3741-3751. 2018
Structure-function relationships in the oligomeric NADPH-dependent assimilatory sulfite reductase. 57:3764-3772. 2018
Structural characterization of the hydratase-aldolases, NahE and PhdJ: implications for the specificity, catalysis, and N-acetylneuraminate lyase subgroup of the aldolase superfamily. 57:3524-3536. 2018
Structural insights into the free-standing condensation enzyme SgcC5 catalyzing ester-bond formation in the biosynthesis of the enediyne antitumor antibiotic C-1027. 57:3278-3288. 2018
Characterization of a sulfated anti-HIV antibody using an expanded genetic code. 57:2903-2907. 2018
Functionalized peptides: ideal targets for collaborative chemistry. 57:2745-2746. 2018
Reentrant phase transitions and non-equilibrium dynamics in membraneless organelles. 57:2470-2477. 2018
Semisynthetic organisms with expanded genetic codes. 57:2177-2178. 2018
CH···O hydrogen bonds mediate highly specific recognition of methylated CpG sites by the zinc finger protein kaiso. 57:2109-2120. 2018
Characterization of an A-site selective protein disulfide isomerase A1 inhibitor. 57:2035-2043. 2018
Splicing site recognition by synergy of three domains in splicing factor RBM10. 57:1563-1567. 2018
Another one (of the “undruggable" targets) bites the dust: discovery of a potent and selective inhibitor of the histone acetyl transferase p300/CBP. 57:899-900. 2018
Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53. 57:935-944. 2018
Inactivation of 4-oxalocrotonate tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. 57:1012-1021. 2018
PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates. 57:1003-1011. 2018
A structure-based assembly screen of protein cage libraries in living cells: experimentally repacking a protein-protein interface to recover cage formation in an assembly-frustrated mutant. 57:604-613. 2018
Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets. 57:827-838. 2018
Statistical coupling analysis-guided library design for the discovery of mutant luciferases. 57:663-671. 2018
Applications of oxygenases in the chemoenzymatic total synthesis of complex natural products. 57:403-412. 2018
Templated self-assembly of dynamic peptide nucleic acids. 57:160-172. 2018
Discovery and biological evaluation of potent and selective N-methylene saccharin-derived inhibitors for rhomboid intramembrane proteases. 56:6713-6725. 2017
The autophagy-related Beclin-1 protein requires the coiled-coil and BARA domains to form a homodimer with submicromolar affinity. 56:6639-6651. 2017
Incomplete refolding of antibody light chains to non-native, protease-sensitive conformations leads to aggregation: a mechanism of amyloidogenesis in patients?. 56:6597-6614. 2017
Novel biology and druggable targets via chemoproteomics. 56:6515-6516. 2017
A vision for vaccines: combating the opioid epidemic. 56:5625-5627. 2017
Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner. 56:5570-5581. 2017
Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9. 56:5476-5480. 2017
A method for the exponential synthesis of RNA: introducing the polymerase chain transcription (PCT) reaction. 56:5227-5228. 2017
Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins. 56:5269-5273. 2017
Pathogenic mutations induce partial structural changes in the native β-sheet structure of transthyretin and accelerate aggregation. 56:4808-4818. 2017
Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T. 56:4154-4168. 2017
Residue-Specific Peptide Modification: A Chemist's Guide. 56:3863-3873. 2017
Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1. 56:3463-3474. 2017
Identification of microprotein-protein interactions via APEX tagging. 56:3299-3306. 2017
Conformational heterogeneity and the affinity of substrate molecular recognition by cytochrome P450cam. 56:3248-3256. 2017
Conformational heterogeneity and DNA recognition by the morphogen bicoid. 56:2787-2793. 2017
The cation-π interaction enables a Halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification. 56:1585-1595. 2017
Structural snapshots of an engineered cystathionine-γ-lyase reveal the critical role of electrostatic interactions in the active site. 56:876-885. 2017
Structural analysis provides mechanistic insight into nicotine oxidoreductase from pseudomonas putida. 55:6595-6598. 2016
Chemoproteomic evaluation of target engagement by the cyclin-dependent kinase 4 and 6 inhibitor palbociclib correlates with cancer cell response. 55:5434-5441. 2016
Solid-state NMR studies reveal native-like β-sheet structures in transthyretin amyloid. 55:5272-5278. 2016
Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the enediyne antitumor antibiotic C-1027 in streptomyces globisporus. 55:5142-5154. 2016
EF5 is the high-affinity Mg2+ site in ALG-2. 55:5128-5141. 2016
Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins. 55:4885-4908. 2016
Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c. 55:4807-4822. 2016
Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipase. 55:4636-4641. 2016
Functional conversion of CPD and (6-4) photolyases by mutation. 55:4173-4183. 2016
Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations. 55:1997-2007. 2016
Structural changes associated with transthyretin misfolding and amyloid formation revealed by solution and solid-state NMR. 55:1941-1944. 2016
Chemical inhibitors of epigenetic methyllysine reader proteins. 55:1570-1583. 2016
Folding of fibroblast growth factor 1 is critical for its nonclassical release. 55:1159-1167. 2016
Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages. 55:960-969. 2016
Structural changes of the active center during the photoactivation of xenopus (6-4) photolyase. 55:715-723. 2016
Allosteric inhibition of human ribonucleotide reductase by dATP entails the stabilization of a hexamer. 55:373-381. 2016
Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892. 54:6842-6851. 2015
Taq DNA polymerase mutants and 2'-modified sugar recognition. 54:5999-6008. 2015
Prb1 protease activity is required for its recognition by the F-Box protein Saf1. 54:4423-4426. 2015
Identification and co-complex structure of a new S. pyogenes SpeB small molecule inhibitor. 54:4365-4373. 2015
Dual allosteric inhibitors jointly modulate protein structure and dynamics in the hepatitis C virus polymerase. 54:4131-4141. 2015
Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10). 54:3851-3859. 2015
Preformed soluble chemoreceptor trimers that mimic cellular assembly states and activate CheA autophosphorylation. 54:3454-3468. 2015
ATP acyl phosphate reactivity reveals native conformations of Hsp90 para logs and inhibitor target engagement. 54:3024-3036. 2015
Lipid-directed vinculin dimerization. 54:2758-2768. 2015
ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. 54:2539-2549. 2015
Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly. 54:2240-2248. 2015
Adaptive mutations alter antibody structure and dynamics during affinity maturation. 54:2085-2093. 2015
The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA. 54:1743-1757. 2015
A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase. 54:881-889. 2015
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I). 54:753-764. 2015
Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion. 53:7884-7892. 2014
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. 53:7854-7865. 2014
BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. 53:6901-6909. 2014
Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity. 53:6820-6824. 2014
Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus. 53:6511-6519. 2014
Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase alpha-helices. 53:5864-5875. 2014
A complex equilibrium among partially unfolded conformations in monomeric transthyretin. 53:4381-4392. 2014
Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus. 53:4467-4475. 2014
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. 53:4426-4433. 2014
Probing the non-native H helix translocation in apomyoglobin folding intermediates. 53:3767-3780. 2014
Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. 53:2153-2165. 2014
Quantification of transthyretin kinetic stability in human plasma using subunit exchange. 53:1993-2006. 2014
Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids. 53:1495-1510. 2014
Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase. 53:1155-1168. 2014
Side chain conformational averaging in human dihydrofolate reductase. 53:1134-1145. 2014
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry-activity-based protein profiling. 52:9187-9201. 2013
Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies. 52:8420-8429. 2013
The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function. 52:8226-8236. 2013
Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). 52:8069-8078. 2013
Bifacial peptide nucleic acid directs cooperative folding and assembly of binary, ternary, and quaternary DNA complexes. 52:6313-6323. 2013
TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning. 52:5577-5584. 2013
Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. 52:5430-5440. 2013
Predictive Model for Epoxide Hydrolase-Generated Stereochemistry in the Biosynthesis of Nine-Membered Enediyne Antitumor Antibiotics. 52:5217-5224. 2013
Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. 52:5133-5144. 2013
A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase. 52:4605-4619. 2013
Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamics. 52:4541-4552. 2013
Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS study. 52:3866-3880. 2013
The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. 52:3852-3865. 2013
Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle. 52:3464-3477. 2013
Development and mechanism of γ-secretase modulators for Alzheimer's disease. 52:3197-3216. 2013
Age-related oxidative modifications of transthyretin modulate its amyloidogenicity. 52:1913-26. 2013
A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coli. 52:1828-1837. 2013
A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. 52:1490-1499. 2013
Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. 52:1227-1235. 2013
Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock. 52:1208-1220. 2013
Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy. 52:1019-1027. 2013
Structure of the bifunctional acyltransferase/decarboxylase lnmk from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. 52:902-911. 2013
Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases. 52:640-652. 2013
Light-induced subunit dissociation by a light-oxygen-voltage domain photoreceptor from Rhodobacter sphaeroides. 52:378-391. 2013
Potent mechanism-based inactivation of cytochrome p450 2b4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome p450 catalysis. 52:355-364. 2013
Substrate-induced control of product formation by protein arginine methyltransferase 1. 52:199-209. 2013
Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation. 51:9954-9965. 2012
Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer. 51:9857-9868. 2012
The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state. 51:9581-9591. 2012
Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 51:8384-8390. 2012
BMS-708,163 targets presenilin and lacks notch-sparing activity. 51:7209-7211. 2012
Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules. 51:7225-7238. 2012
High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy. 51:6350-6359. 2012
Fourier-transform infrared study of the photoactivation process of xenopus (6-4) photolyase. 51:5774-5783. 2012
Mobility of Xe atoms within the oxygen diffusion channel of cytochrome ba(3) oxidase. 51:4669-4676. 2012
Specific binding of a beta-cyclodextrin dimer to the amyloid beta peptide modulates the peptide aggregation process. 51:4280-4289. 2012
A variable light domain fluorogen activating protein homodimerizes to activate dimethylindole red. 51:2471-2485. 2012
Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. 51:2232-2245. 2012
Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. 51:1028-1040. 2012
Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant. 51:665-676. 2012
Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site. 51:329-341. 2012
Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid. 50:11070-11083. 2011
Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. 50:11143-11161. 2011
Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. 50:10647-10657. 2011
Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations. 50:9928-9935. 2011
Lipocalin Q83 reveals a dual ligand binding mode with potential implications for the functions of siderocalins. 50:9192-9199. 2011
Design and characterization of stabilized derivatives of human cd4d12 and cd4d1. 50:7891-7900. 2011
Investigating endogenous peptides and peptidases using peptidomics. 50:7447-7461. 2011
Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway. 50:7600-7611. 2011
Controlling conformational flexibility of an O(2)-binding H-NOX domain. 50:6832-6840. 2011
Determinants of the heme-CO vibrational modes in the H-NOX family. 50:6519-6530. 2011
The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites. 50:6113-6124. 2011
Influence of histidine tag attachment on picosecond protein dynamics. 50:5799-5805. 2011
Determinants of membrane activity from mutational analysis of the HIV fusion peptide. 50:5195-5207. 2011
Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. 50:4903-4911. 2011
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease. 50:4371-4381. 2011
Probing domain interactions in soluble guanylate cyclase. 50:4281-4290. 2011
Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity. 50:3997-4010. 2011
Stabilization of a protein nanocage through the plugging of a protein-protein interfacial water pocket. 50:4029-4037. 2011
Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility. 50:4019-4028. 2011
FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase. 50:3591-3598. 2011
Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. 50:3332-3345. 2011
Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. 50:2486-2498. 2011
A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. 50:2213-2222. 2011
Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope. 50:2092-2100. 2011
An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity. 50:1894-1900. 2011
A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. 50:1607-1617. 2011
Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation. 50:1567-1581. 2011
Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches. 50:962-969. 2011
Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. 50:1001-1015. 2011
NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)(2) reveal a dynamic UU internal loop found in myotonic dystrophy type 1. 50:599-601. 2011
Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel. 50:693-703. 2011
Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry. 50:207-220. 2011
A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. 50:9545-9550. 2011
Pivotal roles of three conserved carboxyl residues of the nuoc (30k) segment in the structural integrity of proton-translocating nadh-quinone oxidoreductase from escherichia coli. 49:10072-10080. 2010
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein. 49:9964-9971. 2010
Mechanistic studies of agmatine deiminase from multiple bacterial species. 49:9413-9423. 2010
Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation. 49:9046-9057. 2010
Key dynamics of conserved asparagine in a cryptochrome/photolyase family protein by fourier transform infrared spectroscopy. 49:8882-8891. 2010
Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel. 49:8709-8720. 2010
Functional role of thr-312 and thr-315 in the proton-transfer pathway in ba(3) cytochrome c oxidase from thermus thermophilus. 49:7033-7039. 2010
Human DNA ligase iii recognizes DNA ends by dynamic switching between two DNA-bound states. 49:6165-6176. 2010
Structure and properties of a bis-histidyl ligated globin from caenorhabditis elegans. 49:5662-5670. 2010
Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence. 49:4864-4871. 2010
Substrate specificity and kinetic studies of pads 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. 49:4852-4863. 2010
Heme binding to the mammalian circadian clock protein period 2 is nonspecific. 49:4327-4338. 2010
Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation. 49:4094-4102. 2010
Probing soluble guanylate cyclase activation by co and yc-1 using resonance raman spectroscopy. 49:3815-3823. 2010
Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy. 49:3824-3841. 2010
P450cam visits an open conformation in the absence of substrate. 49:3412-3419. 2010
Characterization of the ubiquinone binding site in the alternative nadh-quinone oxidoreductase of saccharomyces cerevisiae by photoaffinity labeling. 49:2973-2980. 2010
Structural dynamics and single-stranded DNA binding activity of the three n-terminal domains of the large subunit of replication protein a from small angle x-ray scattering. 49:2880-2889. 2010
Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides. 49:1833-1842. 2010
Generating permissive site-specific unnatural aminoacyl-tRNA synthetases. 49:1667-1677. 2010
Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. 49:1541-1548. 2010
Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. 49:1331-1337. 2010
Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. 49:727-735. 2010
Molecularly defined antibody conjugation through a selenocysteine interface. 48:12047-12057. 2009
Peptidomics of prolyl endopeptidase in the central nervous system. 48:11971-11981. 2009
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. 48:11370-11380. 2009
Assembly of hybrid bacteriophage Qβ virus-like particles. 48:11155-11157. 2009
NMR spectroscopic characterization of the sialyltransferase CstII from campylobacter jejuni: Histidine 188 is the general base. 48:11220-11230. 2009
Identification of emerging quasi-species in directed enzyme evolution. 48:9330-9339. 2009
Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. 48:9590-9598. 2009
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange. 48:9668-9676. 2009
Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction. 48:9306-9312. 2009
Mutagenesis and evolution of sulfated antibodies using an expanded genetic code. 48:8891-8898. 2009
Resonance raman spectra of an o2-binding h-nox domain reveal heme relaxation upon mutation. 48:8568-8577. 2009
Prion proteins with pathogenic and protective mutations show similar structure and dynamics. 48:8120-8128. 2009
Functional dynamics of the folded ankyrin repeats of i kappa b alpha revealed by nuclear magnetic resonance. 48:8023-8031. 2009
Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. 48:7698-7704. 2009
Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. 48:7547-7555. 2009
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. 48:7365-7372. 2009
Nucleotide regulation of soluble guanylate cyclase substrate specificity. 48:7519-7524. 2009
Signal recognition particle (srp) and srp receptor: A new paradigm for multistate regulatory gtpases. 48:6696-6704. 2009
A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. 48:6288-6290. 2009
Synthesis of nitric oxide by the nos-like protein from deinococcus radiodurans: A direct role for tetrahydrofolate. 48:5483-5491. 2009
Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning. 48:4762-4771. 2009
Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. 48:3417-3424. 2009
Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris. 48:2643-2653. 2009
Chemical frustration in the protein folding landscape: Grand canonical ensemble simulations of cytochrome c. 48:2394-2402. 2009
Mapping the interactions of the p53 transactivation domain with the kix domain of cbp. 48:2115-2124. 2009
The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals. 48:1936-1944. 2009
Quantification of the vitamin D receptor-coregulator interaction. 48:1454-1461. 2009
Accommodation of two diatomic molecules in cytochrome bo(3): Insights into no reductase activity in terminal oxidases. 48:883-890. 2009
Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes. 48:820-826. 2009
Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism. 48:110-120. 2009
Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. 48:10591-10600. 2009
Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes. 47:13470-13480. 2008
Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. 47:13514-13523. 2008
The intrinsically disordered rnr inhibitor sml1 is a dynamic dimer. 47:13428-13437. 2008
The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster. 47:12740-12749. 2008
Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions. 47:12670-12679. 2008
Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase. 47:12389-12397. 2008
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase. 47:12251-12253. 2008
Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains. 47:11793-11803. 2008
The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50. 47:11446-11456. 2008
Repair of o(6)-g-alkyl-o(6)-g interstrand cross-links by human o(6)-alkylguanine-DNA alkyltransferase. 47:10892-10903. 2008
Synthesis and characterization of new piperazine-type inhibitors for mitochondrial nadh-ubiquinone oxidoreductase (complex i). 47:10816-10826. 2008
Kinetic mechanism of protein arginine methyltransferase 1. 47:10420-10427. 2008
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. 47:9900-9910. 2008
Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. 47:9756-9770. 2008
Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm. 47:9456-9466. 2008
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. 47:9227-9233. 2008
Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. 47:7999-8006. 2008
Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. 47:7782-7784. 2008
Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation. 47:7695-7705. 2008
Exploring the energy landscape of antibody-antigen complexes: Protein dynamics, flexibility, and molecular recognition. 47:7237-7247. 2008
Light activation of the LOV protein Vivid generates a rapidly exchanging dimer. 47:7012-7019. 2008
Sre1, an iron-modulated gata DNA-binding protein of iron-uptake genes in the fungal pathogen histoplasma capsulatum. 47:7274-7283. 2008
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. 47:6969-6984. 2008
Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. 47:6361-6369. 2008
Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidases. 47:4657-4665. 2008
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. 47:3892-3899. 2008
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. 47:3917-3925. 2008
Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1. 47:3076-3084. 2008
Nmr relaxation study of the complex formed between cbp and the activation domain of the nuclear hormone receptor coactivator actr. 47:1299-1308. 2008
Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?. 47:50-59. 2008
Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, gyc-88e, from drosophila. 46:15115-15122. 2007
Structural models for the KCNQ1 voltage-gated potassium channel. 46:14141-14152. 2007
Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxid. 46:13677-13683. 2007
Protein arginine methyltransferase 1: Positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. 46:13370-13381. 2007
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. 46:13019-13030. 2007
Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue. 46:12289-12297. 2007
Evidence that tRNA synthetase-directed proton transfer stops mistranslation. 46:12062-12070. 2007
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4. 46:11559-11567. 2007
An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance. 46:11223-11230. 2007
Biogenesis of the secretory granule: Chromogranin a coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation. 46:10999-11012. 2007
Elucidation of the interleukin-15 binding site on its alpha receptor by NMR. 46:9453-9461. 2007
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. 46:9578-9585. 2007
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. 46:8744-8752. 2007
Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding. 46:8085-8099. 2007
Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications. 46:7832-7843. 2007
Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms. 46:7196-7204. 2007
The structure of l-tyrosine 2,3-aminomutase from the c-1027 enediyne antitumor antibiotic biosynthetic pathway. 46:7205-7214. 2007
Protein arginine deiminase 4: Evidence for a reverse protonation mechanism. 46:6578-6587. 2007
The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I. 46:6409-6416. 2007
Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation. 46:5552-5561. 2007
Functional characterization of the heterooligomeric ebrab multidrug efflux transporter of bacillus subtilis. 46:5218-5225. 2007
Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicing. 46:4861-4875. 2007
Alpha-synuclein multistate folding thermodynamics: Implications for protein misfolding and aggregation. 46:4499-4509. 2007
3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle. 46:3942-3951. 2007
Substrate tolerance of module 6 of the epothilone synthetase. 46:3385-3393. 2007
Structural basis for spinophilin-neurabin receptor interaction. 46:2333-2344. 2007
The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. 46:1503-1510. 2007
Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. 46:659-668. 2007
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. 46:359-368. 2007
Functional interrogation of the kinome using nucleotide acyl phosphates. 46:350-358. 2007
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis. 46:145-155. 2007
A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways. 45:15529-15540. 2006
Evidence for activation of tissue factor by an allosteric disulfide bond. 45:12020-12028. 2006
Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization. 45:11727-11736. 2006
Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): Discovery of phosphorylcholine derivatives of N-acyl ethanolamines. 45:11267-11277. 2006
Kinetic mechanism of RGS9-1 potentiation by R9AP. 45:10690-10697. 2006
Structural characterization of enterobactin hydrolase IroE. 45:10184-10190. 2006
Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. 45:9434-9444. 2006
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. 45:9007-9015. 2006
Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids. 45:9016-9022. 2006
Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate. 45:8903-8911. 2006
Structural mobility in human manganese superoxide dismutase. 45:8209-8215. 2006
Carboxyl terminus of Helicobacter pylori alpha 1,3-fucosyltransferase determines the structure and stability. 45:8108-8116. 2006
EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate : ferredoxin oxidoreductase. 45:7122-7131. 2006
Identification of hydrophobic residues critical for DPP-IV dimerization. 45:7006-7012. 2006
Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B. 45:7162-7170. 2006
Discovery of different types of inhibition between the human and Thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives. 45:5695-5702. 2006
Interaction of α-and β-oligoarginine-acids and amides with anionic lipid vesicles: a mechanistic and thermodynamic study. 45:5817-5829. 2006
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. 45:4720-4726. 2006
Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution. 45:4463-4473. 2006
Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. 45:3835-3844. 2006
Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity. 45:3255-3262. 2006
The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule. 45:3297-3306. 2006
Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation. 45:2537-2544. 2006
Heparin accelerates gelsolin amyloidogenesis. 45:2234-2242. 2006
Nmr-derived dynamic aspects of n-type inactivation of a kv channel suggest a transient interaction with the t1 domain. 45:1663-1672. 2006
Nmr solution structure of the peptide fragment 1-30, derived from unprocessed mouse doppel protein, in dhpc micelles. 45:159-166. 2006
Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation. 45:263-271. 2006
Partitioning conformational intermediates between competing refolding and aggregation pathways: Insights into transthyretin amyloid disease. 44:16612-16623. 2005
Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: Hydrodynamic and fluorescence anisotropy decay analyses. 44:16602-16611. 2005
Characterization of functional heme domains from soluble guanylate cyclase. 44:16266-16274. 2005
Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. 44:16257-16265. 2005
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. 44:16211-16220. 2005
The pathway by which the tetrameric protein transthyretin dissociates. 44:15525-15533. 2005
Nmr analyses of the activation of the arp2/3 complex by neuronal wiskott-aldrich syndrome protein. 44:15247-15256. 2005
Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library. 44:14845-14853. 2005
Investigation of the iron-sulfur cluster in mycobacterium tuberculosis APS reductase: Implications for substrate binding and catalysis. 44:14647-14657. 2005
Phosphorylation of aquaporin pvtip3;1 defined by mass spectrometry and molecular modeling. 44:14443-14454. 2005
Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. 44:14486-14493. 2005
Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. 44:14143-14151. 2005
Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. 44:13457-13466. 2005
Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from escherichia coli. 44:13553-13559. 2005
Proton release due to manganese binding and oxidation in modified bacterial reaction centers. 44:13266-13273. 2005
Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2. 44:11997-12008. 2005
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. 44:11525-11538. 2005
Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. 44:11428-11439. 2005
Kinetic characterization of protein arginine deiminase 4: A transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. 44:10570-10582. 2005
Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from naja atra venom that targets the BKCa channel. 44:10145-10152. 2005
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. 44:10046-10053. 2005
Structure of the 1,4-bis(2 '-deoxyadenosin-N-6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide. 44:10081-10092. 2005
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: Linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation. 44:9833-9840. 2005
Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition. 44:9574-9580. 2005
Structure-based engineering of internal cavities in coiled-coil peptides. 44:9723-9732. 2005
Characterization of the membrane domain subunit nuok (nd4l) of the nadh-quinone oxidoreductase from escherichia coli. 44:9545-9554. 2005
Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice?. 44:9079-9085. 2005
Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: Implications for transthyretin amyloidosis. 44:9265-9274. 2005
Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. 44:8989-8997. 2005
Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase. 44:7593-7601. 2005
Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II. 44:7389-7394. 2005
Development of small designer aldolase enzymes: Catalytic activity, folding, and substrate specificity. 44:7583-7592. 2005
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. 44:4977-4983. 2005
S-nitrosation and regulation of inducible nitric oxide synthase. 44:4636-4647. 2005
The tertiary structure of the hairpin ribozyme is formed through a slow conformational search. 44:4870-4876. 2005
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. 44:4196-4203. 2005
Variant of human enzyme sequesters reactive intermediate. 44:4216-4221. 2005
Expression and characterization of the catalytic domains of soluble guanylate cyclase: Interaction with the heme domain. 44:4083-4090. 2005
Characterization of the membrane domain subunit nuoj (nd6) of the nadh-quinone oxidoreductase from escherichia coli by chromosomal DNA manipulation. 44:3562-3571. 2005
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras Codon 61 sequence. 44:3327-3337. 2005
Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly. 44:2800-2810. 2005
Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation. 44:2732-2745. 2005
Understanding GFP chromophore biosynthesis: Controlling backbone cyclization and modifying post-translational chemistry. 44:1960-1970. 2005
Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. 44:1097-1105. 2005
Amino acid substitution and modification resulting from escherichia coli expression of recombinant plasmodium falciparum histidine-rich protein ii. 44:987-995. 2005
Heme binding to the histidine-rich protein ii from plasmodium falciparum. 44:979-986. 2005
Cbp/p300 taz1 domain forms a structured scaffold for ligand binding. 44:490-497. 2005
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. 43:16046-16055. 2004
Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants. 43:15379-15392. 2004
Assignment of endogenous substrates to enzymes by global metabolite profiling. 43:14332-14339. 2004
Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus. 43:14128-14138. 2004
Nmr structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 m urea. 43:13937-13943. 2004
On the solution structure of the t4 sliding clamp (gp45). 43:12723-12727. 2004
Cytochrome rc(552), formed during expression of the truncated, thermus thermophilus cytochrome c(552) gene in the cytoplasm of escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl (spirographis) heme. 43:12162-12176. 2004
Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. 43:12090-12104. 2004
Isomerase-independent chaperone function of cyclophilin ensures aggregation prevention of adenosine kinase both in vitro and under in vivo conditions. 43:11862-11872. 2004
Mechanistic studies of a flavin-dependent thymidylate synthase. 43:10295-10301. 2004
Prion protein interaction with the c-terminal sh3 domain of grb2 studied using NMR and optical spectroscopy. 43:10393-10399. 2004
Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from vibrio cholerae and thermoanaerobacter tengcongensis. 43:10203-10211. 2004
In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display. 43:9265-9275. 2004
The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA. 43:8725-8734. 2004
Identification and characterization of a novel RNA binding protein that associates with the 5 '-untranslated region of the chloroplast psbA mRNA. 43:8541-8550. 2004
Comparison of anandamide transport in FAAH wild-type and knockout neurons: Evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. 43:8184-8190. 2004
Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10. 43:8067-8076. 2004
Nickel superoxide dismutase structure and mechanism. 43:8038-8047. 2004
Transthyretin aggregation under partially denaturing conditions is a downhill polymerization. 43:7365-7381. 2004
Role of hydrogen bonding in the active site of human manganese superoxide dismutase. 43:7038-7045. 2004
Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin. 43:6519-6534. 2004
Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA. 43:3518-3526. 2004
Subunit proximity in the h+-translocating nadh-quinone oxidoreductase probed by zero-length cross-linking. 43:3750-3755. 2004
Subunit exchange by CheA histidine kinases from the mesophile Escherichia coli and the thermophile Thermotoga maritima. 43:2228-2240. 2004
Mode of action for linear peptide inhibitors of hiv-1 gp120 interactions. 43:1928-1938. 2004
Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope. 43:1410-1417. 2004
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. 43:1171-1183. 2004
Nonrandom structure in the urea-unfolded escherichia coli outer membrane protein x (ompx). 43:860-869. 2004
Histone - DNA binding free energy cannot be measured in dilution-driven dissociation experiments. 43:736-741. 2004
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. 43:374-383. 2004
Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant delta E-torsinA. 42:15333-15341. 2003
A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol). 42:13193-13201. 2003
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity. 42:13287-13303. 2003
Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases. 42:12989-12997. 2003
Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis. 42:12708-12718. 2003
Conformational change in the nadp(h) binding domain of transhydrogenase defines four states. 42:12143-12153. 2003
Reduction potentials of rieske clusters: Importance of the coupling between oxidation state and histidine protonation state. 42:12400-12408. 2003
Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: Trigger for microdomain/raft formation?. 42:12028-12037. 2003
Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site. 42:10904-10914. 2003
Mechanisms of redox-coupled proton transfer in proteins: Role of the proximal proline in reactions of the 3fe-4s cluster in azotobacter vinelandii ferredoxin i. 42:10589-10599. 2003
Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor. 42:10619-10626. 2003
Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression. 42:9598-9608. 2003
Blmiii and bimiv nonribosornal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. 42:9731-9740. 2003
Oxidase domains in epothilone and bleomycin biosynthesis: Thiazoline to thiazole oxidation during chain elongation. 42:9722-9730. 2003
C5L2, a nonsignaling C5A binding protein. 42:9406-9415. 2003
Electrostatic tuning of ion conductance in potassium channels. 42:9263-9268. 2003
Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions. 42:8756-8761. 2003
High-resolution structure of the soluble, respiratory-type rieske protein from thermus thermophilus: Analysis and comparison. 42:7303-7317. 2003
Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes. 42:7348-7357. 2003
A new strategy for the site-specific modification of proteins in vivo. 42:6735-6746. 2003
D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?. 42:6656-6663. 2003
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. 42:6043-6056. 2003
Characterization and topology of the membrane domain nqo10 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans. 42:4534-4543. 2003
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. 42:3997-4008. 2003
Site-specific mutations provide new insights into the origin of pH effects and alternative spectral forms in the photoactive yellow protein from Halorhodospira halophila. 42:3319-3325. 2003
A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis. 42:2916-2925. 2003
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel. 42:2781-2789. 2003
Role of electrostatic interactions in PDZ domain ligand recognition. 42:2797-2805. 2003
Bifunctional abletadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. 42:2700-2707. 2003
The proton-translocating nadh-quinone oxidoreductase in the respiratory chain: The secret unlocked. 42:2266-2274. 2003
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. 42:2137-2148. 2003
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase. 42:1969-1977. 2003
A molecular motor or a regulator? Dynamin's in a class of its own. 42:1369-1376. 2003
Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide. 42:1646-1651. 2003
The nd5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex i. 42:746-754. 2003
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes. 42:6370-6379. 2003
Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding. 42:9335-9345. 2003
Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes. 42:6363-6369. 2003
Probing backbone hydrogen bonds in the hydrophobic core of GCN4. 41:15676-15684. 2002
Structural insights into the avian aicar transformylase mechanism. 41:15505-15513. 2002
Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR. 41:14206-14215. 2002
Energetics of hydrogen bond networks in rna: Hydrogen bonds surrounding g+1 and u42 are the major determinants for the tertiary structure stability of the hairpin ribozyme. 41:14095-14102. 2002
Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine. 41:14232-14237. 2002
Breaking and re-forming the disulfide bond at the high-potential, respiratory-type rieske 2fe-2s center of thermus thermophilus: Characterization of the sulfhydryl state by protein-film voltammetry. 41:14054-14065. 2002
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. 41:13915-13925. 2002
Activation of angiogenic signaling pathways by two human tRNA synthetases. 41:13344-13349. 2002
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type iii (akrlc2). 41:13451-13459. 2002
A nonproteolytic function of the 19s regulatory subunit of the 26s proteasome is required for efficient activated transcription by human rna polymerase ii. 41:12798-12805. 2002
Crystal structures of transhydrogenase domain i with and without bound nadh. 41:12745-12754. 2002
Molecular hinges in protein folding: The urea-denatured state of apomyoglobin. 41:12681-12686. 2002
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. 41:12569-12574. 2002
Biochemical characterization and structural analysis of a highly proficient cocaine esterase. 41:12297-12307. 2002
Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids. 41:12509-12519. 2002
Evidence that phospholipids play a key role in pre-beta apoa-i formation and high-density lipoprotein remodeling. 41:12538-12545. 2002
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. 41:11981-11989. 2002
Structural biology of viruses by the combination of electron cryomicroscopy and x-ray crystallography. 41:11517-11524. 2002
Probing the Tetrahymena group I ribozyme reaction in both directions. 41:11171-11183. 2002
Structure of a nitric oxide synthase heme protein from Bacillus subtilis. 41:11071-11079. 2002
Redox properties of the 2fe-2s center in the 24 kda (nqo2) subunit of nadh : Ubiquinone oxidoreductase (complex i). 41:10056-10069. 2002
Role of zymogenicity-determining residues of coagulation factor vii/viia in cofactor interaction and macromolecular substrate recognition. 41:9302-9309. 2002
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. 41:9229-9236. 2002
Kinetic mechanism for human rho-kinase ii (rock-ii). 41:8948-8953. 2002
Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases. 41:8429-8437. 2002
Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine. 41:8113-8119. 2002
The amino terminus of opsin translocates "posttranslationally" as efficiently as cotranslationally. 41:7707-7715. 2002
Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop. 41:7001-7007. 2002
Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor. 41:6688-6696. 2002
Characterization of the membrane domain nqo11 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans. 41:4377-4384. 2002
3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting. 41:3943-3951. 2002
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: Evidence for the involvement of tetrahydrobiopterin in electron transfer. 41:3439-3456. 2002
Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment. 41:713-722. 2002
Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism. 41:772-779. 2002
Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1. 40:15835-15845. 2001
Conformational and dynamic characterization of the molten globule state of an apomyoglobin mutant with an altered folding pathway. 40:14459-14467. 2001
Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila. 40:14509-14517. 2001
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. 40:13538-13547. 2001
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. 40:12826-12832. 2001
Long-range effects on calcium binding and conformational change in the n-domain of calmodulin. 40:12719-12726. 2001
Kinetic analysis of product inhibition in human manganese superoxide dismutase. 40:12051-12058. 2001
Aminoacyl-S-enzyme intermediates in β-hydroxylations and α,β-desaturations of amino acids in peptide antibiotics. 40:11651-11659. 2001
Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1. 40:11660-11669. 2001
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. 40:11442-11452. 2001
Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy. 40:11453-11459. 2001
Energetics and affinity of the histone octamer for defined DNA sequences. 40:10927-10933. 2001
Tertiary structure stability of the hairpin ribozyme in its natural and minimal forms: Different energetic contributions from a ribose zipper motif. 40:11211-11218. 2001
A comparative analysis of the immunological evolution of antibody 28B4. 40:10764-10773. 2001
Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells. 40:10839-10845. 2001
Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate. 40:10655-10663. 2001
Backbone dynamics in dihydrofolate reductase complexes: Role of loop flexibility in the catalytic mechanism. 40:9846-9859. 2001
Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k. 40:9887-9895. 2001
Application of cross-correlated NMR spin relaxation to the zinc-finger protein CRP2(LIM2): evidence for collective motions in LIM domains. 40:9596-9604. 2001
Evidence that ga111 protein is a target of the ga14 activation domain in the mediator. 40:9421-9427. 2001
Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1. 40:8487-8498. 2001
Turn structures in cgrp c-terminal analogues promote stable arrangements of key residue side chains. 40:8317-8325. 2001
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion. 40:7351-7354. 2001
Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. 40:7736-7745. 2001
Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation. 40:6795-6804. 2001
Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2 '-o-methyl hexanucleotides. 40:6520-6526. 2001
Recognition elements for 5 ' exon substrate binding to the Candida albicans group I intron. 40:6507-6519. 2001
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. 40:6107-6115. 2001
Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG. 40:5587-5592. 2001
The crystal structure of a fusagenic sperm protein reveals extreme surface properties. 40:5407-5413. 2001
Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid. 40:4478-4483. 2001
Profiling serine hydrolase activities in complex proteomes. 40:4005-4015. 2001
NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding. 40:3561-3571. 2001
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities. 40:2702-2711. 2001
Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics. 40:2743-2753. 2001
A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking. 40:2580-2587. 2001
Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9. 40:1937-1944. 2001
Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with cd4. 40:1662-1670. 2001
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure. 40:1265-1273. 2001
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function. 40:1274-1283. 2001
Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy. 40:987-993. 2001
Crystal structure of the von Willebrand factor modulator botrocetin. 40:345-352. 2001
Escherichia coli lipa is a lipoyl synthase: In vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. 39:15166-15178. 2000
A structure-based approach to a synthetic vaccine for hiv-1. 39:14377-14391. 2000
Role of residue phe(225) in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor viia. 39:14457-14463. 2000
Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron. 39:14269-14278. 2000
hsp70 interacting protein hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. 39:14314-14321. 2000
Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein. 39:13478-13486. 2000
Dynamics of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor. 39:13356-13364. 2000
Kinetics and reactivity of the flavin and heme cofactors of cellobiose dehydrogenase from phanerochaete chrysosporium. 39:13595-13601. 2000
Helical junctions as determinants for rna folding: Origin of tertiary structure stability of the hairpin ribozyme. 39:12970-12978. 2000
Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase. 39:12585-12594. 2000
Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid. 39:12485-12493. 2000
Changes in the apomyoglobin folding pathway caused by mutation of the distal histidine residue. 39:11227-11237. 2000
Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x. 39:11467-11476. 2000
Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms. 39:10950-10957. 2000
Inhibition of soluble guanylate cyclase by odq. 39:10848-10854. 2000
Asymmetric DNA binding by a homodimeric bHLH protein. 39:9092-9098. 2000
Exploring the membrane domain of the reduced nicotinamide adenine dinucleotide-quinone oxidoreductase of paracoccus denitrificans: Characterization of the nqo7 subunit. 39:9411-9418. 2000
Errors from selective disruption of the editing center in a tRNA synthetase. 39:8180-8186. 2000
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis. 39:7131-7137. 2000
Targeting a pneumocystis carinii group i intron with methylphosphonate oligonucleotides: Backbone charge is not required for binding or reactivity. 39:6991-7000. 2000
The conformation of apolipoprotein a-i in high-density lipoproteins is influenced by core lipid composition and particle size: A surface plasmon resonance study. 39:5712-5721. 2000
Alternative splicing of Wilms' tumor suppressor protein modulates DNA binding activity through isoform-specific DNA-induced conformational changes. 39:5341-5348. 2000
Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. 39:4608-4621. 2000
Interaction of soluble guanylate cyclase with yc-1: Kinetic and resonance raman studies. 39:4191-4198. 2000
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1. 39:3141-3148. 2000
Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin. 39:2894-2901. 2000
Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase. 39:2208-2217. 2000
Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum. 39:1613-1621. 2000
Protonation states and pH titration in the photocycle of photoactive yellow protein. 39:1100-1113. 2000
Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement. 39:627-632. 2000
Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a. 39:592-598. 2000
Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme a reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition. 39:237-247. 2000
Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes. 39:183-193. 2000
Intramolecular activation of a Ca2+-dependent protein kinase is disrupted by insertions in the tether that connects the calmodulin-like domain to the kinase. 39:4004-4011. 2000
New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid. 38:16783-16793. 1999
Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase. 38:16898-16903. 1999
Determination of fe-ligand bond lengths and the fe-n-o bond angles in soybean ferrous and ferric nitrosylleghemoglobin alpha using multiple-scattering xafs analyses. 38:16491-16499. 1999
Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron. 38:16655-16662. 1999
Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex. 38:16359-16365. 1999
NMR observation of selected segments in a larger protein: Central-segment isotope labeling through intein-mediated ligation. 38:16040-16044. 1999
The C-terminal region of human glutathione transferase Al-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9. 38:16268-16275. 1999
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen. 38:15689-15696. 1999
Identification of modified tryptophan residues in apolipoprotein b-100 derived from copper ion-oxidized low-density lipoprotein. 38:15903-15908. 1999
Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli. 38:15915-15926. 1999
The glycine residue in cyclic lactam analogues of galanin(1-16)-nh2 is important for stabilizing an n-terminal helix. 38:15295-15304. 1999
Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. 38:14810-14819. 1999
NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop. 38:14507-14514. 1999
Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. 38:14338-14351. 1999
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism. 38:14125-14130. 1999
Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate. 38:14363-14378. 1999
Dual photoactive species in Glu46Asp and Glu46Ala mutants of photoactive yellow protein: A pH-driven color transition. 38:13766-13772. 1999
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. 38:13480-13490. 1999
The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. 38:13560-13573. 1999
Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix. 38:12080-12088. 1999
Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. 38:11686-11692. 1999
Engineered recombinant factor vii q(217) variants with altered inhibitor specificities. 38:10940-10948. 1999
Tertiary structure stabilization promotes hairpin ribozyme ligation. 38:11040-11050. 1999
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. 38:10801-10807. 1999
Chemical and mutagenic investigations of fatty acid amide hydrolase: Evidence for a family of serine hydrolases with distinct catalytic properties. 38:9804-9812. 1999
Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2. 38:9982-9991. 1999
Conformational changes of gp120 in epitopes near the ccr5 binding site are induced by cd4 and a cd4 miniprotein mimetic. 38:9405-9416. 1999
Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site. 38:9254-9263. 1999
Oxidized and reduced azotobacter vinelandii ferredoxin i at 1.4 Å resolution: Conformational change of surface residues without significant change in the 3fe-4s (+/0) cluster. 38:8228-8239. 1999
Selenomethionine-substituted thermus thermophilus cytochrome ba3: Characterization of the cu-a site by se and cuk-exafs. 38:7075-7084. 1999
Structural basis for antibody catalysis of a disfavored ring closure reaction. 38:7062-7074. 1999
An animal virus-derived peptide switches membrane morphology: Possible relevance to nodaviral transfection processes. 38:5328-5336. 1999
The coral-derived natural products eleutherobin and sarcodictyins a and b: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. 38:5490-5498. 1999
Characterization of the DNA binding properties of the bHLH domain of Deadpan to single and tandem sites. 38:5138-5146. 1999
Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases. 38:4965-4971. 1999
Mutation of an active site residue in escherichia coli uracil-DNA glycosylase: Effect on DNA binding, uracil inhibition and catalysis. 38:4834-4845. 1999
Nmr solution structure of alpha-conotoxin imi and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors. 38:3874-3882. 1999
N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides. 38:3235-3245. 1999
Interaction of DNA polymerase i (klenow fragment) with DNA substrates containing extrahelical bases: Implications for proofreading of frameshift errors during DNA synthesis. 38:2661-2668. 1999
Regulation of the catalytic function of coagulation factor viia by a conformational linkage of surface residue glu 154 to the active site. 38:2745-2751. 1999
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase. 38:2367-2376. 1999
Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain. 38:1957-1966. 1999
Studying low-density lipoprotein-monoclonal antibody complexes using dynamic laser light scattering and analytical ultracentrifugation. 38:1284-1292. 1999
The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence. 38:596-604. 1999
Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate. 38:848-852. 1999
Spectroscopic characterization of the heme-binding sites in plasmodium falciparum histidine-rich protein 2. 38:16916-16924. 1999
Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: Implications for wild-type, V30M, and L55P amyloid fibril formation. 37:17851-17864. 1998
Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase. 37:16853-16862. 1998
Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: Acceleration by thiols and oxyhemoglobin. 37:16898-16907. 1998
Characterization of interactions between a two-component response regulator, spo0f, and its phosphatase, rapb. 37:16538-16545. 1998
Molecular basis for p38 protein kinase inhibitor specificity. 37:16573-16581. 1998
Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19. 37:16270-16279. 1998
Resonance raman characterization of the heme domain of soluble guanylate cyclase. 37:16289-16297. 1998
Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 Å resolution. 37:15638-15646. 1998
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. 37:15503-15512. 1998
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: Identification of the transmembrane domain as a site for oligomerization. 37:15177-15187. 1998
Structural and kinetic evidence for strain in biological catalysis. 37:14404-14409. 1998
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site. 37:13437-13445. 1998
The 0.78 Å structure of a serine protease: Bacillus lentus subtilisin. 37:13446-13452. 1998
Mechanism and utility of an RNA-cleaving DNA enzyme. 37:13330-13342. 1998
Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase. 37:12458-12464. 1998
New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: Photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant. 37:11563-11568. 1998
Solution structure of the N-terminal EGF-like domain from human factor VII. 37:10605-10615. 1998
A small, thermostable, and monofunctional chorismate mutase from the archeon Methanococcus jannaschii. 37:10062-10073. 1998
Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin. 37:10298-10306. 1998
NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist. 37:9169-9178. 1998
Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine. 37:9193-9202. 1998
A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site. 37:7725-7732. 1998
Structure and intramodular dynamics of the amino-terminal LIM domain from quail cysteine- and glycine-rich protein CRP2. 37:7127-7134. 1998
Characterization of the ubiquinone reduction site of mitochondrial complex i using bulky synthetic ubiquinones. 37:6436-6445. 1998
Characterization of y122f r2 of escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and x-ray crystallography. 37:5840-5848. 1998
Recognition properties of a sequence-specific DNA binding antibody. 37:6015-6022. 1998
Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c. 37:5464-5474. 1998
Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34. 37:4722-4730. 1998
Deletion of amino acids glu146 -> arg160 in human apolipoprotein a-i (apoa-i-seattle) alters lecithin : Cholesterol acyltransferase activity and recruitment of cell phospholipid. 37:4863-4868. 1998
Probing the active site of human manganese superoxide dismutase: The role of glutamine 143. 37:4731-4739. 1998
Identification of histidine 105 in the beta 1 subunit of soluble guanylate cyclase as the heme proximal ligand. 37:4502-4509. 1998
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of emp1. 37:3699-3710. 1998
Effect of redox state on the folding free energy of a thermostable electron-transfer metalloprotein: The cu-a domain of cytochrome oxidase from thermus thermophilus. 37:3172-3177. 1998
Recognition of sequence-directed DNA structure by the klenow fragment of DNA polymerase i. 37:1898-1904. 1998
Structural dynamics of hiv-1 rev and its complexes with rre and 5s rna. 37:1800-1809. 1998
Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment). 37:1513-1522. 1998
Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in bacillus subtilis. 37:1365-1375. 1998
Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions. 37:779-782. 1998
Localization of the heme binding region in soluble guanylate cyclase. 36:15959-15964. 1997
Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli. 36:14930-14938. 1997
Formation of n-delta-cyanoornithine from n-g-hydroxy-l-arginine and hydrogen peroxide by neuronal nitric oxide synthase: Implications for mechanism. 36:14465-14473. 1997
Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin. 36:13461-13472. 1997
A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis. 36:12739-12745. 1997
Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: Structures of the escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. 36:12120-12137. 1997
Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange. 36:12101-12119. 1997
An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis. 36:11314-11322. 1997
Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions. 36:11252-11260. 1997
Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. 36:10666-10674. 1997
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. 36:10696-10708. 1997
Kinetic mechanism for p38 map kinase. 36:10422-10427. 1997
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism. 36:10517-10525. 1997
Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: Equilibria with high kinetic barriers. 36:10230-10239. 1997
High-resolution NMR structure and backbone dynamics of the bacillus subtilis response regulator, spoof: Implications for phosphorylation and molecular recognition. 36:10015-10025. 1997
Collagen-based structures containing the peptoid residue n-isobutylglycine (nleu): Conformational analysis of gly-nleu-pro sequences by h-1-NMR and molecular modeling. 36:8725-8732. 1997
Collagen-based structures containing the peptoid residue n-isobutylglycine (nleu): Synthesis and biophysical studies of gly-nleu-pro sequences by circular dichroism and optical rotation. 36:8716-8724. 1997
Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility. 36:7305-7312. 1997
Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase. 36:6739-6744. 1997
Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin. 36:5234-5244. 1997
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding. 36:5097-5103. 1997
Structural analysis of Z-Z DNA junctions with A:A and T:T mismatched base pairs by NMR. 36:4258-4267. 1997
Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. 36:3056-3060. 1997
Kinetics of folding of the IgG binding domain of peptostreptoccocal protein L. 36:3373-3382. 1997
Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57. 36:2622-2636. 1997
Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack. 36:823-831. 1997
Why is CMP-ketodeoxyoctonate highly unstable?. 36:780-785. 1997
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein. 36:8-14. 1997
Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase. 36:12337-12345. 1997
Reconstruction of quaternary structures of class II tRNA synthetases by rational mutagenensis of a conserved domain. 36:15041-15048. 1997
Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain. 35:13222-13230. 1996
Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme. 35:11693-11701. 1996
Mechanism and specificity of human α-1,3-fucosyltransferase V. 35:11183-11195. 1996
Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. 35:10464-10471. 1996
A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug. 35:9995-10003. 1996
Structural studies of the proton-translocating nadh-quinone oxidoreductase (ndh-1) of paracoccus denitrificans: Identity, property, and stoichiometry of the peripheral subunits. 35:9120-9127. 1996
Regiospecificity of aminoglycoside phosphotransferase from enterococci and staphylococci (aph(3')-iiia). 35:8686-8695. 1996
Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center. 35:7834-7845. 1996
Characterization of c415 mutants of neuronal nitric oxide synthase. 35:7772-7780. 1996
Conformational flexibility of three-way DNA junctions containing unpaired nucleotides. 35:7959-7967. 1996
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1. 35:7731-7742. 1996
Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance. 35:6375-6384. 1996
The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. 35:6470-6482. 1996
Mutational analysis suggests the same design for editing activities of two tRNA synthetases. 35:5596-5601. 1996
Altering substrate specificity at the heme edge of cytochrome c peroxidase. 35:4858-4866. 1996
Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface. 35:4287-4297. 1996
C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase. 35:4139-4145. 1996
Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus. 35:3387-3395. 1996
Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase. 35:3258-3262. 1996
A phosphotransferase activity of the bacillus subtilis sporulation protein spoof that employs phosphoramidate substrates. 35:2926-2933. 1996
Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from streptomyces lividans. 35:2332-2341. 1996
Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase. 35:2316-2321. 1996
Association between the amino- and carboxyl-terminal halves of lactose permease is specific and mediated by multiple transmembrane domains. 35:2016-2021. 1996
Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with resonance raman spectroscopy. 35:1540-1547. 1996
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. 35:1093-1099. 1996
Method for predicting the state of association of discretized protein models. Application to leucine zippers. 35:955-967. 1996
Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis. 35:608-615. 1996
Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR. 35:1-6. 1996
A mechanism for reducing entropic cost of induced fit in protein-RNA recognition. 35:8095-8102. 1996
Structure of a dicationic monoimidazole lexitropsin bound to DNA. 34:16654-16661. 1995
Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase. 34:6014-6019. 1995
The ferrous heme of soluble guanylate cyclase: Formation of hexacoordinate complexes with carbon monoxide and nitrosomethane. 34:16397-16403. 1995
Interaction between the escherichia-coli regulatory protein tyrr and DNA - a fluorescence footprinting study. 34:15802-15812. 1995
Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase. 34:15638-15645. 1995
Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes. 34:15813-15828. 1995
Exploring the role of the solvent in the denaturation of a protein - a molecular-dynamics study of the DNA-binding domain of the 434-repressor. 34:15057-15067. 1995
Heme stoichiometry of heterodimeric soluble guanylate cyclase. 34:14668-14674. 1995
Mechanism of inhibition of human-leukocyte elastase by beta-lactams .3. Use of electrospray-ionization mass-spectrometry and 2-dimensional NMR techniques to identify beta-lactam-derived e-i-complexes. 34:14344-14355. 1995
Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease. 34:13527-13536. 1995
Species-specific microhelix aminoacylation by a eukaryotic pathogen tRNA synthetase dependent on a single base pair. 34:12489-12495. 1995
Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features. 34:11037-11048. 1995
Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA. 34:11204-11210. 1995
Tissue factor residues lys(165) and lys(166) are essential for rapid formation of the quaternary complex of tissue-factor-center-dot-viia with xa-center-dot-tissue factor pathway inhibitor. 34:10867-10871. 1995
Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition. 34:10340-10349. 1995
Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. 34:10560-10568. 1995
Proton sharing between cysteine thiols in Escherichia coli thioredoxin: implications for the mechanism of protein disulfide reduction. 34:10101-10105. 1995
Identification of apolipoprotein b100 polymorphisms that affect low-density-lipoprotein metabolism - description of a new approach involving monoclonal-antibodies and dynamic light-scattering. 34:9571-9580. 1995
Malonyl-coenzyme a-acyl carrier protein acyltransferase of streptomyces-glaucescens - a possible link between fatty-acid and polyketide biosynthesis. 34:9389-9402. 1995
The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the klenow fragment of escherichia-coli polymerase-i and bacteriophage-t4 DNA-polymerase. 34:9185-9192. 1995
Isolated RNA binding domain of a class I tRNA synthetase. 34:8896-8903. 1995
Gene synthesis, high-level expression, and mutagenesis of Thiobacillus ferrooxidans rusticyanin: His 85 is a ligand to the blue copper center. 34:6640-6648. 1995
Nonessential active-site residues modulate selenosubtilisins kinetic mechanism. 34:6616-6620. 1995
1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore. 34:6278-6287. 1995
Energetic contributions and topographical organization of ligand-binding residues of tissue factor. 34:6310-6315. 1995
Nitric oxide complexes of inducible nitric oxide synthase: Spectral characterization and effect on catalytic activity. 34:5627-5634. 1995
Refinement of netropsin bound to DNA - bias and feedback in electron-density map interpretation. 34:4983-4993. 1995
Highly specific oxidative cross-linking of proteins mediated by a nickel-peptide complex. 34:4733-4739. 1995
Hydrogen peroxide-supported oxidation of ng-hydroxy-l-arginine by nitric oxide synthase. 34:1930-1941. 1995
Structure-function in escherichia-coli iron superoxide-dismutase - comparisons with the manganese enzyme from thermus-thermophilus. 34:1646-1660. 1995
X-ray-absorption spectroscopy of the iron site in escherichia-coli fe(iii) superoxide-dismutase. 34:1661-1668. 1995
Crystal-structure of C-T-C-T-C-G-A-G-A-G - implications for the structure of the Holliday junction. 34:1022-1029. 1995
Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry. 34:720-723. 1995
Optical studies of a bacterial photoreceptor protein, photoactive yellow protein, in single-crystals. 34:879-890. 1995
Comparison of the hydrogen exchange behavior of reduced and oxidized Escherichia coli thioredoxin. 34:611-619. 1995
Direct measurement of thermodynamic and kinetic-parameters of DNA triple-helix formation by fluorescence spectroscopy. 33:15329-15337. 1994
Characterization of neuronal nitric oxide synthase and a c415h mutant, purified from a baculovirus overexpression system. 33:14723-14732. 1994
Characterization of the inactivation of nitric oxide synthase by ng-methyl-l-arginine: Evidence for heme loss. 33:14784-14791. 1994
Complete chemical-structure of photoactive yellow protein - novel thioester-linked 4-hydroxycinnamyl chromophore and photocycle chemist. 33:14369-14377. 1994
Crystal-structure of a covalent DNA drug adduct - anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. 33:13593-13610. 1994
Projection structure of the chip28 water channel in lipid bilayer-membranes at 12 Å resolution. 33:12735-12740. 1994
Stabilizing and destabilizing effects of placing beta-branched amino-acids in protein alpha-helices. 33:12022-12031. 1994
Continuous in vitro evolution of bacteriophage RNA polymerase promoters. 33:11980-11986. 1994
Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1. 33:11717-11723. 1994
Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution. 33:11699-11706. 1994
Melting of a DNA helix terminus within the active-site of a DNA-polymerase. 33:11971-11979. 1994
Factor viia residue arg(290) is required for efficient activation of the macromolecular substrate factor-x. 33:11631-11636. 1994
Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies. 33:11073-11078. 1994
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin. 33:10646-10651. 1994
Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure. 33:9904-9911. 1994
Transient hydrogen-bonds identified on the surface of the NMR solution structure of hirudin. 33:9303-9310. 1994
Differences in pressure stability of the 3 components of cowpea mosaic-virus - implications for virus assembly and disassembly. 33:8339-8346. 1994
Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation. 33:8029-8034. 1994
Genetic identification of an autoinhibitor in CDPK, a protein kinase with a calmodulin-like domain. 33:7267-7277. 1994
Broad-spectrum aminoglycoside phosphotransferase type-iii from enterococcus - overexpression, purification, and substrate-specificity. 33:6936-6944. 1994
Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. 33:5966-5973. 1994
The NMR structure of the pulmonary surfactant-associated polypeptide sp-c in an apolar solvent contains a valyl-rich alpha-helix. 33:6015-6023. 1994
Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. 33:5636-5640. 1994
Region of a conserved sequence motif in a class II tRNA synthetase needed for transfer of an activated amino acid to an RNA substrate. 33:5312-5318. 1994
Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels. 33:5098-5108. 1994
Inactivation of interleukin-1-beta converting-enzyme by peptide (acyloxy)methyl ketones. 33:3934-3940. 1994
Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase. 33:3807-3818. 1994
Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs. 33:2741-2747. 1994
Spectroscopic characterization of cytochrome ba(3), a terminal oxidase from thermus-thermophilus - comparison of the a(3)/cu-b site to that of bovine cytochrome aa(3). 33:3128-3141. 1994
Site-directed mutagenesis of a catalytic antibody - an arginine and a histidine residue play key roles. 33:1994-2003. 1994
Control of the murine phosphofructokinase-a gene during muscle differentiation. 33:1771-1777. 1994
Mutational mapping of functional residues in tissue factor - identification of factor-vii recognition determinants in both structural modules of the predicted cytokine receptor homology domain. 33:1565-1572. 1994
Dynamics of a flexible loop in dihydrofolate-reductase from escherichia-coli and its implication for catalysis. 33:439-442. 1994
Expression of the 25-kilodalton iron-sulfur subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans. 33:494-499. 1994
Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate. 33:773-779. 1994
An RNA binding site in a tRNA synthetase with a reduced set of amino acids. 33:11040-11045. 1994
Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization. 33:14213-14220. 1994
Conformational distributions of a 4-way DNA junction revealed by time-resolved fluorescence resonance energy-transfer. 32:13852-13860. 1993
Triple aminoacylation specificity of a chimerized transfer RNA. 32:14053-14061. 1993
Structure and dynamics of the sialic-acid moiety of g(m3)-ganglioside at the surface of a magnetically oriented membrane. 32:13405-13413. 1993
Nmr evidence for multiple conformations in a highly helical model peptide. 32:13089-13097. 1993
A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. 32:12656-12663. 1993
Characterization of a folding intermediate of apoplastocyanin trapped by proline isomerization. 32:12299-12310. 1993
Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization. 32:12128-12135. 1993
Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity. 32:12119-12127. 1993
Tetracenomycin-f2 cyclase - intramolecular aldol condensation in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens. 32:11149-11154. 1993
Ng-methyl-l-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase. 32:9677-9685. 1993
Crystallographic analysis of C-C-A-A-G-C-T-T-G-G and its implications for bending in B-DNA. 32:8923-8931. 1993
Electrostatic calculations of side-chain pk(a) values in myoglobin and comparison with NMR data for histidines. 32:8045-8056. 1993
Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III. 32:7861-7865. 1993
Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors. 32:7787-7798. 1993
Tetracenomycin f1-monooxygenase - oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens. 32:6656-6663. 1993
Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin. 32:6337-6347. 1993
Peptide models of protein folding initiation sites. 2. The G-H turn region of myoglobin acts as a helix stop signal. 32:6348-6355. 1993
Peptide models of protein folding initiation sites. 3. The G-H helical hairpin of myoglobin. 32:6356-6364. 1993
Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III. 32:5786-5791. 1993
Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation. 32:5267-5272. 1993
Designed replacement of an internal hydration water molecule in bpti - structural and functional implications of a glycine-to-serine mutation. 32:4564-4570. 1993
Disulfide bond isomerization in bpti and bpti(g36s) - an NMR-study of correlated mobility in proteins. 32:3571-3582. 1993
Assignment of h-1, n-15, and c-13 resonances, identification of elements of secondary structure and determination of the global fold of the DNA-binding domain of gal4. 32:2144-2153. 1993
Electrospray ionization mass-spectrometry as a mechanistic tool - mass of human-leukocyte elastase and a beta-lactam-derived e-i complex. 32:2031-2035. 1993
DNA sequencing of the 7 remaining structural genes of the gene-cluster encoding the energy-transducing nadh-quinone oxidoreductase of paracoccus-denitrificans. 32:968-981. 1993
Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using (15)N NMR relaxation measurements. 32:426-435. 1993
Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc). 32:32-37. 1993
C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation. 32:13026-13031. 1993
Comparison of the lysine binding functions of lipoprotein(a) and plasminogen. 32:13681-13687. 1993
Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole. 32:12793-12801. 1993
Kinetics of intermolecular cleavage by hammerhead ribozymes. 31:12042-12054. 1992
Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution. 31:10310-10314. 1992
Magnetic circular-dichroism study of cytochrome-ba3 from thermus-thermophilus - spectral contributions from cytochrome-b and cytochrome-a3 and nanosecond spectroscopy of co photodissociation intermediates. 31:9376-9387. 1992
Structural and functional-characterization of the mutant escherichia-coli glutaredoxin(c14- s) and its mixed disulfide with glutathione. 31:9288-9293. 1992
Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. 31:8654-8660. 1992
Functional-role of a mobile loop of escherichia-coli dihydrofolate-reductase in transition-state stabilization. 31:7826-7833. 1992
Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction. 31:7899-7907. 1992
Macrophage nitric oxide synthase: Relationship between enzyme-bound tetrahydrobiopterin and synthase activity. 31:7160-7165. 1992
Gene-cluster of the energy-transducing nadh-quinone oxidoreductase of paracoccus-denitrificans - characterization of 4 structural gene-products. 31:6925-6932. 1992
Mechanistic probes of n-hydroxylation of l-arginine by the inducible nitric oxide synthase from murine macrophages. 31:6822-6828. 1992
Nitric oxide synthase is a cytochrome p-450 type hemoprotein. 31:6627-6631. 1992
Studies of virus structure by laser raman-spectroscopy .35. Conformations, interactions, and thermostabilities of rna and proteins in bean pod mottle virus - investigation of solution and crystal-structures by laser raman-spectroscopy. 31:6673-6682. 1992
RNA tetraloops as minimalist substrates for aminoacylation. 31:4931-4936. 1992
Assignment of the aliphatic h-1 and c-13 resonances of the bacillus-subtilis glucose permease-iia domain using double-resonance and triple-resonance heteronuclear 3-dimensional NMR-spectroscopy. 31:4413-4425. 1992
Backbone dynamics of the bacillus-subtilis glucose permease-iia domain determined from n-15 NMR relaxation measurements. 31:4394-4406. 1992
Novel transfer RNAs that are active in Escherichia coli. 31:4157-4160. 1992
The antitumor agent cc-1065 inhibits helicase-catalyzed unwinding of duplex DNA. 31:3968-3975. 1992
Conformation and dynamics of an fab'-bound peptide by isotope-edited NMR-spectroscopy. 31:3862-3871. 1992
Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase. 31:3026-3032. 1992
Crystal-structures of aconitase with isocitrate and nitroisocitrate bound. 31:2735-2748. 1992
Immunogenic peptides corresponding to the dominant antigenic region alanine-597 to cysteine-619 in the transmembrane protein of simian immunodeficiency virus have a propensity to fold in aqueous solution. 31:1458-1463. 1992
Activation of methotrexate-alpha-alanine by carboxypeptidase-A monoclonal-antibody conjugate. 31:891-897. 1992
Solution structure of murine epidermal growth-factor determined by NMR-spectroscopy and refined by energy minimization with restraints. 31:236-249. 1992
Mechanistic studies of a tyrosine-dependent catalytic antibody. 30:9757-9761. 1991
Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120. 30:9187-9194. 1991
Opposite facial specificity for 2 hydroquinone epoxidases - (3-si,4-re)-2,5-dihydroxyacetanilide epoxidase from streptomyces ll-c10037 and (3-re,4-si)-2,5-dihydroxyacetanilide epoxidase from streptomyces mpp-3051. 30:8936-8944. 1991
Interaction of DNA with the klenow fragment of DNA-polymerase-i studied by time-resolved fluorescence spectroscopy. 30:8759-8770. 1991
Characterization of the 25-kilodalton subunit of the energy-transducing nadh ubiquinone oxidoreductase of paracoccus-denitrificans - sequence similarity to the 24-kilodalton subunit of the flavoprotein fraction of mammalian complex-i. 30:8678-8684. 1991
Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine. 30:8463-8470. 1991
Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B. 30:8395-8401. 1991
Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic-nucleotide phosphodiesterase from bovine brain. 30:7931-7940. 1991
Evidence for a "cysteine-histidine box" metal-binding site in an Escherichia coli aminoacyl-tRNA synthetase. 30:6970-6976. 1991
Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy. 30:6896-6907. 1991
The NMR structure of cyclosporine-a bound to cyclophilin in aqueous-solution. 30:6563-6574. 1991
The nadh-binding subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans - gene cloning and deduced primary structure. 30:6422-6428. 1991
A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1. 30:6097-6102. 1991
Use of recombinant-DNA derived human relaxin to probe the structure of the native protein. 30:6006-6013. 1991
Fluorescence anisotropy decay of ethidium bound to nucleosome core particles .2. The torsional motion of the DNA is highly constrained and sensitive to ph. 30:5304-5313. 1991
Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR. 30:4262-4268. 1991
Circular-dichroism and magnetic circular-dichroism of azotobacter-vinelandii ferredoxin-i. 30:3200-3209. 1991
Dynamics of mismatched base-pairs in DNA. 30:3271-3279. 1991
Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase. 30:2514-2518. 1991
Evidence for 2 interconverting protein isomers in the methotrexate complex of dihydrofolate-reductase from escherichia-coli. 30:2184-2191. 1991
Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca. 30:1957-1964. 1991
Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis. 30:1484-1490. 1991
Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. 30:1682-1691. 1991
Assembly of a class I tRNA synthetase from products of an artificially split gene. 30:319-324. 1991
Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli. 30:5202-5209. 1991
Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA. 30:2635-2641. 1991
Recombinant expression, biochemical-characterization, and biological-activities of the human MGSA-gro protein. 29:10225-10233. 1990
Hazards and their exploitation in the applications of molecular biology to structure-function relationships. 29:9495-9502. 1990
Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: evidence for a unique conformation of bound folate. 29:9667-9677. 1990
Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase. 29:9212-9218. 1990
Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by (1)H NMR. 29:7828-7837. 1990
Crystal-structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and ctp or atp at 2.8-a resolution and neutral ph. 29:7702-7715. 1990
Structural consequences of effector binding to the t-state of aspartate carbamoyltransferase - crystal-structures of the unligated and atp-complexed and ctp-complexed enzymes at 2.6-a resolution. 29:7691-7701. 1990
Sequence-specific h-1-NMR assignments and determination of the secondary structure for the activation domain isolated from pancreatic procarboxypeptidase-b. 29:7515-7522. 1990
Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii. 29:6400-6405. 1990
Minimum secondary structure requirements for catalytic activity of a self-splicing group-I intron. 29:6534-6539. 1990
A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. 29:6314-6322. 1990
Identification of the nadh-binding subunit of nadh-ubiquinone oxidoreductase of paracoccus-denitrificans. 29:5515-5520. 1990
Studies of virus structure by laser raman-spectroscopy .26. Structural studies of bean pod mottle virus, capsid, and rna in crystal and solution states by laser raman-spectroscopy. 29:5018-5026. 1990
Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy. 29:4129-4136. 1990
A nucleotide that enhances the charging of RNA minihelix sequence variants with alanine. 29:3621-3626. 1990
Receptor interconversion model of hormone action. 1. Purification of a factor involved in conferring estradiol binding properties to the estrogen receptor. 29:2685-2690. 1990
Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor. 29:2691-2698. 1990
Receptor interconversion model of hormone action. 3. Estrogen receptor mediated repression of reporter gene activity in A431 cells. 29:2699-2702. 1990
Cloning and expression of 3 rabbit kidney cDNAs encoding lauric acid omega-hydroxylases. 29:873-879. 1990
Characterization of the overall and internal dynamics of short oligonucleotides by depolarized dynamic light scattering and NMR relaxation measurements. 29:799-811. 1990
Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells. 28:9337-9343. 1989
Proteolytic fragments of the nicotinic acetylcholine receptor identified by mass spectrometry: implications for receptor topography. 28:9184-9191. 1989
Generation of a catalytic sequence-specific hybrid DNase. 28:8277-8286. 1989
Insertion of new sequences into the catalytic domain of an enzyme. 28:8479-8484. 1989
Characterization of the escherichia-coli transcription factor-delta-70 - localization of a region involved in the interaction with core rna-polymerase. 28:7728-7734. 1989
Stereospecific nuclear magnetic-resonance assignments of the methyl-groups of valine and leucine in the DNA-binding domain of the 434-repressor by biosynthetically directed fractional c-13 labeling. 28:7510-7516. 1989
Transfer of synthetic sialic-acid analogs to n-linked and o-linked glycoprotein glycans using 4 different mammalian sialytransferases. 28:7386-7392. 1989
(1)H NMR studies of the solution conformations of an analog of the C-peptide of ribonuclease A. 28:7059-7064. 1989
Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold. 28:7074-7087. 1989
Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution. 28:6800-6804. 1989
Redox protein electron-transfer mechanisms - electrostatic interactions as a determinant of reaction site in c-type cytochromes. 28:6318-6322. 1989
Electron nuclear double-resonance spectroscopy of n-15-enriched phthalate dioxygenase from pseudomonas-cepacia proves that 2 histidines are coordinated to the 2fe-2s rieske-type clusters. 28:4861-4871. 1989
Conformation of recombinant desulfatohirudin in aqueous-solution determined by nuclear magnetic-resonance. 28:4301-4312. 1989
Static and transient hydrogen-bonding interactions in recombinant desulfatohirudin studied by h-1 nuclear magnetic-resonance measurements of amide proton-exchange rates and ph-dependent chemical-shifts. 28:4312-4317. 1989
Multinuclear NMR studies of DNA hairpins. 1. Structure and dynamics of d(CGCGTTGTTCGCG). 28:2819-2831. 1989
Multinuclear NMR studies of DNA hairpins. 2. Sequence-dependent structural variations. 28:2831-2836. 1989
Parameters for the molecular recognition of transfer RNAs. 28:2747-2759. 1989
A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA. 28:2740-2746. 1989
Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase. 28:2577-2586. 1989
Complete sequence of the human-tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. 28:1755-1762. 1989
Conformational studies of d-(aaaaattttt)2 using constraints from nuclear overhauser effects and from quantitative-analysis of the cross-peak fine-structures in two-dimensional h-1 nuclear magnetic-resonance spectra. 28:1462-1471. 1989
Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo. 28:4942-4947. 1989
H-1-NMR studies of human c3a anaphylatoxin in solution - sequential resonance assignments, secondary structure, and global fold. 27:9139-9148. 1988
Characterization of [4Fe-4Se](2+)/(3+) high-potential iron-sulfur protein from Chromatium vinosum. 27:8712-8719. 1988
Macrophage oxidation of l-arginine to nitrite and nitrate: nitric oxide is an intermediate. 27:8706-8711. 1988
Modification of DNA dynamics by platinum drug-binding - a time-dependent fluorescence depolarization study of the interaction of cis-diamminedichloroplatinum (ii) and trans-diamminedichloroplatinum(ii) with DNA. 27:8599-8606. 1988
H-1-NMR studies of plastocyanin from scenedesmus-obliquus - complete sequence-specific assignment, secondary structure-analysis, and global fold. 27:7806-7816. 1988
The history, properties, and biological effects of cachectin. 27:7575-7582. 1988
Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding. 27:7167-7175. 1988
Morphoregulatory molecules. 27:3533-3543. 1988
Efficient synthesis of a supercoiled m1o DNA molecule containing a site specifically placed psoralen adduct and its use as a substrate for DNA-replication. 27:3210-3215. 1988
Bovine plasminogen activator inhibitor 1: specificity determinations and comparison of the active, latent, and guanidine-activated forms. 27:2911-2918. 1988
Purification and characterization of 2 types of nadh-quinone reductase from thermus-thermophilus hb-8. 27:2008-2013. 1988
Sequence-specific h-1-NMR assignments and identification of slowly exchanging amide protons in murine epidermal growth-factor. 27:2235-2243. 1988
Electron-transfer from cytochrome-b5 to iron and copper-complexes. 26:7102-7107. 1987
Electron paramagnetic resonance study of the active site of copper-substituted human glyoxalase I. 26:6779-6784. 1987
Solid-state n-15 NMR of oriented lipid bilayer bound gramicidin a'. 26:6621-6626. 1987
Amide proton-exchange in the alpha-amylase polypeptide inhibitor tendamistat studied by two-dimensional h-1 nuclear-magnetic-resonance. 26:6488-6493. 1987
Deoxyhexanucleotide containing a vinyl-chloride induced dna lesion, 1,n6-ethenoadenine - synthesis, physical characterization, and incorporation into a duplex bacteriophage-m13 genome as part of an amber codon. 26:5626-5635. 1987
Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns. 26:3763-3768. 1987
Inhibition of nadh ubiquinone reductase-activity by n,n'-dicyclohexylcarbodiimide and correlation of this inhibition with the occurrence of energy-coupling site-1 in various organisms. 26:2822-2828. 1987
Effect of isomers of swainsonine on glycosidase activity and glycoprotein processing. 26:2502-2510. 1987
Multilayered vesicles prepared by reverse-phase evaporation - liposome structure and optimum solute entrapment. 26:17-29. 1987
Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe. 25:6926-6933. 1986
Electron-transfer reactions between flavodoxin semiquinone and c-type cytochromes - comparisons between various flavodoxins. 25:6502-6507. 1986
Inactivation of plasminogen activator inhibitor by oxidants. 25:6351-6355. 1986
Characterization of a fragment of bovine von Willebrand factor that binds to platelets. 25:6325-6335. 1986
Nmr-studies of the complex between the decadeoxynucleotide d-(gcattaatgc)2 and a minor-groove-binding drug. 25:5902-5910. 1986
Purification of a benzo[a]pyrene binding protein by affinity chromatography and photoaffinity labeling. 25:4322-4329. 1986
Purification and characterization of three distinct glutathione transferases from mouse liver. 25:4119-4125. 1986
Binding of coagulation factor-XI to washed human-platelets. 25:3884-3890. 1986
Kinetic-studies of reduction of a 1-1 cytochrome-c flavodoxin complex by free flavin semiquinones and rubredoxin. 25:3318-3328. 1986
Multiple forms of ubiquitin-protein ligase - binding of activated ubiquitin to protein substrates. 25:3134-3138. 1986
Transient kinetics of reduction of blue copper proteins by free flavin and flavodoxin semiquinones. 25:3363-3370. 1986
Horseradish peroxidase catalyzed hydroxylations: Mechanistic studies. 25:2946-2951. 1986
Proton NMR studies of plastocyanin: assignment of aromatic and methyl group resonances from two-dimensional spectra. 25:2364-2374. 1986
Characterization of a second estrogen receptor species in chick oviduct. 25:2073-2081. 1986
Kinetics of electron-transfer between cytochromes-c' and the semiquinones of free flavin and clostridial flavodoxin. 25:1383-1390. 1986
Amide proton-exchange in proteins by ex1 kinetics - studies of the basic pancreatic trypsin-inhibitor at variable p2h and temperature. 24:7396-7407. 1985
Correlation in isolated nuclei of template-engaged RNA polymerase II, ovalbumin mRNA synthesis, and estrogen receptor concentrations. 24:1275-1280. 1985
Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase. 24:6840-6848. 1985
Individual amide proton exchange rates in thermally unfolded basic pancreatic trypsin inhibitor. 24:7407-7411. 1985
Resonance Raman spectra of extracellular ligninase: evidence for a heme active site similar to those of peroxidases. 24:3394-3397. 1985
The oligosaccharide moiety of the beta-1-adrenergic receptor from turkey erythrocytes has a biantennary, n-acetyllactosamine-containing structure. 24:3765-3770. 1985
Two catalytically distinct subforms of cytochrome P-450 3b as obtained from inbred rabbits. 24:7222-7226. 1985
Assignment of acyl chain resonances from membranes of mammalian-cells by two-dimensional NMR methods. 23:5895-5897. 1984
Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers. 23:1029-1036. 1984
Receptors for high molecular-weight kininogen on stimulated washed human-platelets. 23:6863-6869. 1984
Thiols in oxidative-phosphorylation - inhibition and energy-potentiated uncoupling by monothiol and dithiol modifiers. 23:2449-2455. 1984
Use of a monoclonal antibody specific for rabbit microsomal cytochrome P-450 3b to characterize the participation of this cytochrome in the microsomal 6 beta- and 16 alpha-hydroxylation of progesterone. 23:4598-4603. 1984
X-ray absorption studies of the Zn2+ site of glyoxalase I. 23:685-689. 1984
Identification of histidine and methionine residues in the active site of the human uterine progesterone receptor with the affinity labels 11 alpha- and 16 alpha-(bromoacetoxy)progesterone. 22:1729-1734. 1983
Interaction of human-plasma kallikrein and its light chain with C1 inhibitor. 22:4860-4866. 1983
Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides. 22:3610-3617. 1983
N-terminal amino-acid-sequences of the alpha-chains and beta-chains of hla-dr1 and hla-dr2 antigens. 22:185-188. 1983
Partial amino-acid-sequence of a rabbit immunoglobulin light chain of allotype-b5. 22:993-998. 1983
Potentiometric titrations and oxidation-reduction potentials of several iron superoxide dismutases. 22:624-627. 1983
Effects of highly purified estrogen receptors on gene transcription in isolated nuclei. 21:1781-1787. 1982
Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion. 21:4850-4857. 1982
Kinetics of cytochrome-b oxidation in antimycin-treated sub-mitochondrial particles. 21:6614-6618. 1982
Reversible inhibition of the mitochondrial ubiquinol cytochrome-c oxidoreductase complex (complex-iii) by ethoxyformic anhydride. 21:4777-4782. 1982
Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase. 21:2637-2644. 1982
Measurement of heme accessibility in soybean ferric leghemoglobin-a and its complexes by proton magnetic-relaxation. 20:587-594. 1981
Purification of a human progesterone receptor. 20:5557-5565. 1981
Stereochemical outcome of processing of fluorinated substrates by ATP citrate lyase and malate synthase. 20:3719-3723. 1981
C-13 nuclear magnetic-resonance relaxation studies of internal mobility of the polypeptide-chain in basic pancreatic trypsin-inhibitor and a selectively reduced analog. 19:5189-5196. 1980
C-13 nuclear magnetic-resonance studies of the selectively isotope-labeled reactive site peptide-bond of the basic pancreatic trypsin-inhibitor in the complexes with trypsin, trypsinogen, and anhydrotrypsin. 19:5711-5715. 1980
Cd-113 nuclear magnetic-resonance studies of cadmium-substituted derivatives of bovine superoxide-dismutase. 19:591-596. 1980
Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. 19:1151-1160. 1980
Proton nuclear magnetic resonance and electron paramagnetic resonance studies on skeletal muscle actin indicate that the metal and nucleotide binding sites are separate. 19:5912-5916. 1980
Purification of plasminogen-activator from rous-sarcoma virus-transformed chick-embryo fibroblasts treated with the tumor promoter phorbol 12-myristate 13-acetate. 19:5463-5471. 1980
Creatine-kinase - nuclear magnetic-resonance and fluorescence evidence for interaction of adenosine 5'-diphosphate with aromatic residue(s). 18:5050-5055. 1979
Equilibrium and kinetic studies of binding of lens-culinaris lectin to rabbit erythrocytes by a quantitative fluorometric method. 17:5000-5005. 1978
Fluorinated substrate analogues as stereochemical probes of enzymatic reaction mechanisms. 17:5567-5575. 1978
High-field c-13 nuclear magnetic-resonance studies at 90.5 mhz of basic pancreatic trypsin-inhibitor. 17:2263-2269. 1978
Immunological detection of O6-methylguanine in alkylated DNA. 17:1896-1901. 1978
Individual assignments of methyl resonances in h-1 nuclear magnetic-resonance spectrum of basic pancreatic trypsin-inhibitor. 17:2253-2263. 1978
Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver. 17:2978-2984. 1978
Sequence of a rabbit anti-micrococcus-lysodeikticus antibody light chain. 17:4311-4317. 1978
Superoxide-dismutase, a study of electronic properties of copper and zinc by x-ray absorption spectroscopy. 17:1842-1846. 1978
Carbon-13 nuclear magnetic-resonance studies of binding of selectively 13C-enriched oxytocins to neurohypophyseal protein, bovine neurophysin-II. 16:4194-4198. 1977
Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase. 16:4678-4684. 1977
Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs. 16:5454-5460. 1977
Inhibition of an aminoacyl transfer RNA synthetase by a specific trinucleotide derived from the sequence of its cognate transfer RNA. 16:5461-5464. 1977
Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes. 16:250-254. 1977
Purification and characterization of pyridoxal 5'-phosphate dependent serine hydroxymethylase from lamb liver and its action upon beta-phenylserines. 16:5342-5350. 1977
Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy. 16:5061-5065. 1977
Studies of reactions of lamb liver serine hydroxymethylase with l-phenylalanine - kinetic isotope effects upon quinonoid intermediate formation. 16:5350-5354. 1977
Studies of reactions of substituted d,l-erythro-beta-phenylserines with lamb liver serine hydroxymethylase - effects of substituents upon de-aldolization step. 16:5355-5363. 1977
Comparison of isotope labeling patterns of purines in three specific transfer RNAs. 15:2800-2803. 1976
Rate of tritium labeling of specific purines in relation to nucleic acid and particularly transfer RNA conformation. 15:2791-2799. 1976
Sequence composition of template-active fraction of rat-liver chromatin. 15:2472-2483. 1976
13-C nuclear magnetic resonance studies on the lipid organization in enveloped virions (vesicular stomatitis virus). 14:2841-2847. 1975
Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA. 14:2775-2780. 1975
Biophysical studies on the mechanism of quinacrine staining of chromosomes. 13:2937-2945. 1974
Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe. 13:1841-1852. 1974
Effects of abnormal base ionizations on Mg(++) binding to transfer ribonucleic acid as studied by a fluorescent probe. 13:1852-1861. 1974
Protein iodination with solid-state lactoperoxidase. 13:1014-1021. 1974
Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I. 12:387-391. 1973
Human glomerular basement membrane. Selective solubilization with chaotropes and chemical and immunologic characterization of its components. 12:3260-3266. 1973
Observations on the oxidation-reduction properties of bovine erythrocyte superoxide dismutase. 12:4893-4899. 1973
The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119. 12:2096-2099. 1973
Amino acid sequence of rabbit pneumococcal antibody. I. Light-chain cysteine-containing peptides. 11:4978-4985. 1972
An investigation of specific interactions of deoxyribonucleic acid and lysine-rich (F1) histone preparations. 11:1422-1430. 1972
Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid. 11:642-646. 1972
Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid. 11:17-23. 1972
Isolation and proteolytic cleavage of the intact subunit of concanavalin a. 11:3233-3239. 1972
Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate. 11:1582-1589. 1972
Isolation and order of the cyanogen bromide fragments of concanavalin a. 10:3343-3347. 1971
Nanosecond relaxation processes in aqueous mononucleoside solutions. 10:4423-4433. 1971
Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation. 9:3143-3148. 1970
On the rate law and mechanism of the adenosine triphosphate-pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases. 9:480-489. 1970
Small angle x-ray scattering of a homogeneous gamm g-1 immunoglobulin. 9:211-219. 1970
Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits. 9:1195-1205. 1970
The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications. 9:3197-3205. 1970
The covalent structure of a human gamma g-immunoglobulin. 7. Amino acid sequence of heavy-chain cyanogen bromide fragments h1-h4. 9:3161-3170. 1970
The covalent structure of a human gamma g-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments h5-h7. 9:3171-3181. 1970
The covalent structure of a human gamma g-immunoglobulin. Ix. Assignment of asparaginyl and glutaminyl residues. 9:3181-3188. 1970
The covalent structure of a human gamma g-immunoglobulin. Vi. Amino acid sequence of the light chain. 9:3155-3161. 1970
The covalent structure of a human gamma g-immunoglobulin. X. Intrachain disulfide bonds. 9:3188-3196. 1970
Subtypes of rabbit kappa light polypeptide chains associated with the beta locus. 8:2712-2718. 1969
Chemical and immunochemical characterization of electrophoretic subfractions of rabbit gammag-immunoglobulin light chains with b4 allotypic specificity. 7:14-24. 1968
The covalent structure of a human gamma g-immunoglobulin. 3. Arrangement of the cyanogen bromide fragments. 7:1967-1972. 1968
The covalent structure of a human gamma g-immunoglobulin. 4. The interchain disulfide bonds. 7:1973-1982. 1968
The covalent structure of a human gamma g-immunoglobulin. I. Isolation and characterization of the whole molecule, the polypeptide chains, and the tryptic fragments. 7:1950-1958. 1968
The covalent structure of a human gamma g-immunoglobulin. Ii. Isolation and characterization of the cyanogen bromide fragments. 7:1959-1966. 1968
The covalent structure of a human gamma g-immunoglobulin. V. Partial amino acid sequence of the light chain. 7:1983-1994. 1968
The covalent structure of a human γG-immunoglobulin. V. Partial amino acid sequence of the light chain. 7:1983-1994. 1968
Fluorescence polarization of human gamma-g-immunoglobulins. 6:1437-1447. 1967
Fluorescent probes for conformational states of proteins. 3. The activation of chymotrypsinogen. 6:567-572. 1967
Fluorescent probes for conformational states of proteins. Ii. The binding of 2-p-toluidinylnaphthalene-6-sulfonate to alpha-chymotrypsin. 6:559-566. 1967
Fluorescent probes for conformational states of proteins. I. Mechanism of fluorescence of 2-p-toluidinylnaphthalene-6-sulfonate, a hydrophobic probe. 5:1908-1919. 1966
Physical and catalytic properties of tryptophanase from bacillus alvei. 5:3137-3142. 1966
Purification and some properties of tryptophanase from Bacillus alvei. 5:2229-2237. 1966
Optical rotatory dispersion of ribonuclease and ribonuclease-nucleotide complexes. 4:2687-2690. 1965
Resemblance of the gross arrangement of polypeptide chains in reconstituted and native gamma-globulins. 3:1120-1126. 1964

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