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articles

  • Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway.  59:2319-2327. 2020
  • Programmable One-Pot Synthesis of Oligosaccharides.  59:3078-3088. 2020
  • Selection of High-Affinity RNA Aptamers That Distinguish between Doxycycline and Tetracycline.  59:3473-3486. 2020
  • A dynamic switch in inactive p38γ leads to an excited state on the pathway to an active kinase.  58:5160-5172. 2019
  • Structure and dynamics of stacking interactions in an antibody binding site.  58:2987-2995. 2019
  • Eight-letter DNA.  58:2581-2583. 2019
  • Structural, kinetic, and mechanistic analysis of an asymmetric 4-oxalocrotonate tautomerase trimer.  58:2617-2627. 2019
  • Empirical and computational comparison of alternative therapeutic exon skip repairs for duchenne muscular dystrophy.  58:2061-2076. 2019
  • X-ray structures of two bacteroides thetaiotaomicron C11 proteases in complex with peptide-based inhibitors.  58:1728-1737. 2019
  • Synthetic epigenetics to engineer regulation.  58:1558-1559. 2019
  • Role of backbone dynamics in modulating the interactions of disordered ligands with the TAZ1 domain of the CREB-binding protein.  58:1354-1362. 2019
  • A hidden ORF reveals an immune protector.  58:1022-1023. 2019
  • Design, validation, and application of an enzyme-coupled hydrogen sulfide detection assay.  58:474-483. 2019
  • UBC9 mutant reveals the impact of protein dynamics on substrate selectivity and SUMO chain linkages.  58:621-632. 2019
  • Caught in the Act? Quantifying biochemistry inside and outside of biomolecular condensates.  58:142-143. 2019
  • Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin.  57:6919-6922. 2018
  • Structural basis for graded inhibition of CREB:DNA interactions by multi-site phosphorylation.  57:6964-6972. 2018
  • A chemical chaperone decouples TDP-43 disordered domain phase separation from fibrillation.  57:6822-6826. 2018
  • Biochemical characterization and structure-based mutational analysis provide insight into the binding and mechanism of action of novel aspartate aminotransferase inhibitors.  57:6604-6614. 2018
  • A quantitative model for BicD2/cargo interactions.  57:6538-6550. 2018
  • The spastic paraplegia-associated phospholipase DDHD1 is a primary brain phosphatidylinositol lipase.  57:5759-5767. 2018
  • MIEF1 microprotein regulates mitochondrial translation.  57:5564-5575. 2018
  • P450-catalyzed tailoring steps in leinamycin biosynthesis featuring regio- and stereoselective hydroxylations and substrate promiscuities.  57:5005-5013. 2018
  • A HaloTag-based multicolor fluorogenic sensor visualizes and quantifies proteome stress in live cells using solvatochromic and molecular rotor-based fluorophores.  57:4663-4674. 2018
  • NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations.  57:4421-4430. 2018
  • How do intrinsically disordered viral proteins hijack the cell?.  57:4045-4046. 2018
  • Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme.  57:3741-3751. 2018
  • Structure-function relationships in the oligomeric NADPH-dependent assimilatory sulfite reductase.  57:3764-3772. 2018
  • Structural characterization of the hydratase-aldolases, NahE and PhdJ: implications for the specificity, catalysis, and N-acetylneuraminate lyase subgroup of the aldolase superfamily.  57:3524-3536. 2018
  • Structural insights into the free-standing condensation enzyme SgcC5 catalyzing ester-bond formation in the biosynthesis of the enediyne antitumor antibiotic C-1027.  57:3278-3288. 2018
  • Characterization of a sulfated anti-HIV antibody using an expanded genetic code.  57:2903-2907. 2018
  • Functionalized peptides: ideal targets for collaborative chemistry.  57:2745-2746. 2018
  • Reentrant phase transitions and non-equilibrium dynamics in membraneless organelles.  57:2470-2477. 2018
  • Semisynthetic organisms with expanded genetic codes.  57:2177-2178. 2018
  • CH···O hydrogen bonds mediate highly specific recognition of methylated CpG sites by the zinc finger protein kaiso.  57:2109-2120. 2018
  • Characterization of an A-site selective protein disulfide isomerase A1 inhibitor.  57:2035-2043. 2018
  • Splicing site recognition by synergy of three domains in splicing factor RBM10.  57:1563-1567. 2018
  • Another one (of the “undruggable" targets) bites the dust: discovery of a potent and selective inhibitor of the histone acetyl transferase p300/CBP.  57:899-900. 2018
  • Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53.  57:935-944. 2018
  • Inactivation of 4-oxalocrotonate tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.  57:1012-1021. 2018
  • PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates.  57:1003-1011. 2018
  • A structure-based assembly screen of protein cage libraries in living cells: experimentally repacking a protein-protein interface to recover cage formation in an assembly-frustrated mutant.  57:604-613. 2018
  • Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets.  57:827-838. 2018
  • Statistical coupling analysis-guided library design for the discovery of mutant luciferases.  57:663-671. 2018
  • Applications of oxygenases in the chemoenzymatic total synthesis of complex natural products.  57:403-412. 2018
  • Templated self-assembly of dynamic peptide nucleic acids.  57:160-172. 2018
  • Discovery and biological evaluation of potent and selective N-methylene saccharin-derived inhibitors for rhomboid intramembrane proteases.  56:6713-6725. 2017
  • The autophagy-related Beclin-1 protein requires the coiled-coil and BARA domains to form a homodimer with submicromolar affinity.  56:6639-6651. 2017
  • Incomplete refolding of antibody light chains to non-native, protease-sensitive conformations leads to aggregation: a mechanism of amyloidogenesis in patients?.  56:6597-6614. 2017
  • Novel biology and druggable targets via chemoproteomics.  56:6515-6516. 2017
  • A vision for vaccines: combating the opioid epidemic.  56:5625-5627. 2017
  • Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner.  56:5570-5581. 2017
  • Structural basis of single-nucleotide polymorphisms in cytochrome P450 2C9.  56:5476-5480. 2017
  • A method for the exponential synthesis of RNA: introducing the polymerase chain transcription (PCT) reaction.  56:5227-5228. 2017
  • Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins.  56:5269-5273. 2017
  • Pathogenic mutations induce partial structural changes in the native β-sheet structure of transthyretin and accelerate aggregation.  56:4808-4818. 2017
  • Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T.  56:4154-4168. 2017
  • Residue-Specific Peptide Modification: A Chemist's Guide.  56:3863-3873. 2017
  • Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1.  56:3463-3474. 2017
  • Identification of microprotein-protein interactions via APEX tagging.  56:3299-3306. 2017
  • Conformational heterogeneity and the affinity of substrate molecular recognition by cytochrome P450cam.  56:3248-3256. 2017
  • Conformational heterogeneity and DNA recognition by the morphogen bicoid.  56:2787-2793. 2017
  • The cation-π interaction enables a Halo-tag fluorogenic probe for fast no-wash live cell imaging and gel-free protein quantification.  56:1585-1595. 2017
  • Structural snapshots of an engineered cystathionine-γ-lyase reveal the critical role of electrostatic interactions in the active site.  56:876-885. 2017
  • Structural analysis provides mechanistic insight into nicotine oxidoreductase from pseudomonas putida.  55:6595-6598. 2016
  • Chemoproteomic evaluation of target engagement by the cyclin-dependent kinase 4 and 6 inhibitor palbociclib correlates with cancer cell response.  55:5434-5441. 2016
  • Solid-state NMR studies reveal native-like β-sheet structures in transthyretin amyloid.  55:5272-5278. 2016
  • Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the enediyne antitumor antibiotic C-1027 in streptomyces globisporus.  55:5142-5154. 2016
  • EF5 is the high-affinity Mg2+ site in ALG-2.  55:5128-5141. 2016
  • Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins.  55:4885-4908. 2016
  • Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c.  55:4807-4822. 2016
  • Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipase.  55:4636-4641. 2016
  • Functional conversion of CPD and (6-4) photolyases by mutation.  55:4173-4183. 2016
  • Coumarin derivatives as substrate probes of mammalian cytochromes P450 2B4 and 2B6: assessing the importance of 7-Alkoxy chain length, halogen substitution, and non-active site mutations.  55:1997-2007. 2016
  • Structural changes associated with transthyretin misfolding and amyloid formation revealed by solution and solid-state NMR.  55:1941-1944. 2016
  • Chemical inhibitors of epigenetic methyllysine reader proteins.  55:1570-1583. 2016
  • Folding of fibroblast growth factor 1 is critical for its nonclassical release.  55:1159-1167. 2016
  • Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages.  55:960-969. 2016
  • Structural changes of the active center during the photoactivation of xenopus (6-4) photolyase.  55:715-723. 2016
  • Allosteric inhibition of human ribonucleotide reductase by dATP entails the stabilization of a hexamer.  55:373-381. 2016
  • Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892.  54:6842-6851. 2015
  • Taq DNA polymerase mutants and 2'-modified sugar recognition.  54:5999-6008. 2015
  • Prb1 protease activity is required for its recognition by the F-Box protein Saf1.  54:4423-4426. 2015
  • Identification and co-complex structure of a new S. pyogenes SpeB small molecule inhibitor.  54:4365-4373. 2015
  • Dual allosteric inhibitors jointly modulate protein structure and dynamics in the hepatitis C virus polymerase.  54:4131-4141. 2015
  • Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10).  54:3851-3859. 2015
  • Preformed soluble chemoreceptor trimers that mimic cellular assembly states and activate CheA autophosphorylation.  54:3454-3468. 2015
  • ATP acyl phosphate reactivity reveals native conformations of Hsp90 para logs and inhibitor target engagement.  54:3024-3036. 2015
  • Lipid-directed vinculin dimerization.  54:2758-2768. 2015
  • ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.  54:2539-2549. 2015
  • Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.  54:2240-2248. 2015
  • Adaptive mutations alter antibody structure and dynamics during affinity maturation.  54:2085-2093. 2015
  • The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA.  54:1743-1757. 2015
  • A conservative isoleucine to leucine mutation causes major rearrangements and cold sensitivity in KlenTaq1 DNA polymerase.  54:881-889. 2015
  • Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I).  54:753-764. 2015
  • Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.  53:7884-7892. 2014
  • Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.  53:7854-7865. 2014
  • BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.  53:6901-6909. 2014
  • Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.  53:6820-6824. 2014
  • Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus.  53:6511-6519. 2014
  • Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase alpha-helices.  53:5864-5875. 2014
  • A complex equilibrium among partially unfolded conformations in monomeric transthyretin.  53:4381-4392. 2014
  • Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus.  53:4467-4475. 2014
  • Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.  53:4426-4433. 2014
  • Probing the non-native H helix translocation in apomyoglobin folding intermediates.  53:3767-3780. 2014
  • Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.  53:2153-2165. 2014
  • Quantification of transthyretin kinetic stability in human plasma using subunit exchange.  53:1993-2006. 2014
  • Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids.  53:1495-1510. 2014
  • Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase.  53:1155-1168. 2014
  • Side chain conformational averaging in human dihydrofolate reductase.  53:1134-1145. 2014
  • Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry-activity-based protein profiling.  52:9187-9201. 2013
  • Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies.  52:8420-8429. 2013
  • The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function.  52:8226-8236. 2013
  • Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA).  52:8069-8078. 2013
  • Bifacial peptide nucleic acid directs cooperative folding and assembly of binary, ternary, and quaternary DNA complexes.  52:6313-6323. 2013
  • TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning.  52:5577-5584. 2013
  • Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.  52:5430-5440. 2013
  • Predictive Model for Epoxide Hydrolase-Generated Stereochemistry in the Biosynthesis of Nine-Membered Enediyne Antitumor Antibiotics.  52:5217-5224. 2013
  • Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.  52:5133-5144. 2013
  • A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase.  52:4605-4619. 2013
  • Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamics.  52:4541-4552. 2013
  • Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS study.  52:3866-3880. 2013
  • The 3.2 A resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.  52:3852-3865. 2013
  • Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle.  52:3464-3477. 2013
  • Development and mechanism of γ-secretase modulators for Alzheimer's disease.  52:3197-3216. 2013
  • Age-related oxidative modifications of transthyretin modulate its amyloidogenicity.  52:1913-26. 2013
  • A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coli.  52:1828-1837. 2013
  • A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes.  52:1490-1499. 2013
  • Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification.  52:1227-1235. 2013
  • Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.  52:1208-1220. 2013
  • Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy.  52:1019-1027. 2013
  • Structure of the bifunctional acyltransferase/decarboxylase lnmk from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold.  52:902-911. 2013
  • Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases.  52:640-652. 2013
  • Light-induced subunit dissociation by a light-oxygen-voltage domain photoreceptor from Rhodobacter sphaeroides.  52:378-391. 2013
  • Potent mechanism-based inactivation of cytochrome p450 2b4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome p450 catalysis.  52:355-364. 2013
  • Substrate-induced control of product formation by protein arginine methyltransferase 1.  52:199-209. 2013
  • Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation.  51:9954-9965. 2012
  • Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer.  51:9857-9868. 2012
  • The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state.  51:9581-9591. 2012
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).  51:8384-8390. 2012
  • BMS-708,163 targets presenilin and lacks notch-sparing activity.  51:7209-7211. 2012
  • Conformational adaptation of human cytochrome p450 2b6 and rabbit cytochrome p450 2b4 revealed upon binding multiple amlodipine molecules.  51:7225-7238. 2012
  • High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy.  51:6350-6359. 2012
  • Fourier-transform infrared study of the photoactivation process of xenopus (6-4) photolyase.  51:5774-5783. 2012
  • Mobility of Xe atoms within the oxygen diffusion channel of cytochrome ba(3) oxidase.  51:4669-4676. 2012
  • Specific binding of a beta-cyclodextrin dimer to the amyloid beta peptide modulates the peptide aggregation process.  51:4280-4289. 2012
  • A variable light domain fluorogen activating protein homodimerizes to activate dimethylindole red.  51:2471-2485. 2012
  • Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.  51:2232-2245. 2012
  • Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation.  51:1028-1040. 2012
  • Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant.  51:665-676. 2012
  • Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.  51:329-341. 2012
  • Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in cerebrospinal fluid.  50:11070-11083. 2011
  • Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.  50:11143-11161. 2011
  • Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease.  50:10647-10657. 2011
  • Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations.  50:9928-9935. 2011
  • Lipocalin Q83 reveals a dual ligand binding mode with potential implications for the functions of siderocalins.  50:9192-9199. 2011
  • Design and characterization of stabilized derivatives of human cd4d12 and cd4d1.  50:7891-7900. 2011
  • Investigating endogenous peptides and peptidases using peptidomics.  50:7447-7461. 2011
  • Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.  50:7600-7611. 2011
  • Controlling conformational flexibility of an O(2)-binding H-NOX domain.  50:6832-6840. 2011
  • Determinants of the heme-CO vibrational modes in the H-NOX family.  50:6519-6530. 2011
  • The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites.  50:6113-6124. 2011
  • Influence of histidine tag attachment on picosecond protein dynamics.  50:5799-5805. 2011
  • Determinants of membrane activity from mutational analysis of the HIV fusion peptide.  50:5195-5207. 2011
  • Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.  50:4903-4911. 2011
  • A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease.  50:4371-4381. 2011
  • Probing domain interactions in soluble guanylate cyclase.  50:4281-4290. 2011
  • Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity.  50:3997-4010. 2011
  • Stabilization of a protein nanocage through the plugging of a protein-protein interfacial water pocket.  50:4029-4037. 2011
  • Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the clostridium botulinum serotype a neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.  50:4019-4028. 2011
  • FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase.  50:3591-3598. 2011
  • Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1.  50:3332-3345. 2011
  • Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.  50:2486-2498. 2011
  • A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.  50:2213-2222. 2011
  • Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.  50:2092-2100. 2011
  • An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity.  50:1894-1900. 2011
  • A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues.  50:1607-1617. 2011
  • Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.  50:1567-1581. 2011
  • Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.  50:962-969. 2011
  • Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion.  50:1001-1015. 2011
  • NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)(2) reveal a dynamic UU internal loop found in myotonic dystrophy type 1.  50:599-601. 2011
  • Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel.  50:693-703. 2011
  • Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry.  50:207-220. 2011
  • A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.  50:9545-9550. 2011
  • Pivotal roles of three conserved carboxyl residues of the nuoc (30k) segment in the structural integrity of proton-translocating nadh-quinone oxidoreductase from escherichia coli.  49:10072-10080. 2010
  • Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein.  49:9964-9971. 2010
  • Mechanistic studies of agmatine deiminase from multiple bacterial species.  49:9413-9423. 2010
  • Inscribing the perimeter of the PagP hydrocarbon ruler by site-specific chemical alkylation.  49:9046-9057. 2010
  • Key dynamics of conserved asparagine in a cryptochrome/photolyase family protein by fourier transform infrared spectroscopy.  49:8882-8891. 2010
  • Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.  49:8709-8720. 2010
  • Functional role of thr-312 and thr-315 in the proton-transfer pathway in ba(3) cytochrome c oxidase from thermus thermophilus.  49:7033-7039. 2010
  • Human DNA ligase iii recognizes DNA ends by dynamic switching between two DNA-bound states.  49:6165-6176. 2010
  • Structure and properties of a bis-histidyl ligated globin from caenorhabditis elegans.  49:5662-5670. 2010
  • Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence.  49:4864-4871. 2010
  • Substrate specificity and kinetic studies of pads 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.  49:4852-4863. 2010
  • Heme binding to the mammalian circadian clock protein period 2 is nonspecific.  49:4327-4338. 2010
  • Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.  49:4094-4102. 2010
  • Probing soluble guanylate cyclase activation by co and yc-1 using resonance raman spectroscopy.  49:3815-3823. 2010
  • Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy.  49:3824-3841. 2010
  • P450cam visits an open conformation in the absence of substrate.  49:3412-3419. 2010
  • Characterization of the ubiquinone binding site in the alternative nadh-quinone oxidoreductase of saccharomyces cerevisiae by photoaffinity labeling.  49:2973-2980. 2010
  • Structural dynamics and single-stranded DNA binding activity of the three n-terminal domains of the large subunit of replication protein a from small angle x-ray scattering.  49:2880-2889. 2010
  • Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides.  49:1833-1842. 2010
  • Generating permissive site-specific unnatural aminoacyl-tRNA synthetases.  49:1667-1677. 2010
  • Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.  49:1541-1548. 2010
  • Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability.  49:1331-1337. 2010
  • Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.  49:727-735. 2010
  • Molecularly defined antibody conjugation through a selenocysteine interface.  48:12047-12057. 2009
  • Peptidomics of prolyl endopeptidase in the central nervous system.  48:11971-11981. 2009
  • The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.  48:11370-11380. 2009
  • Assembly of hybrid bacteriophage Qβ virus-like particles.  48:11155-11157. 2009
  • NMR spectroscopic characterization of the sialyltransferase CstII from campylobacter jejuni: Histidine 188 is the general base.  48:11220-11230. 2009
  • Identification of emerging quasi-species in directed enzyme evolution.  48:9330-9339. 2009
  • Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.  48:9590-9598. 2009
  • Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.  48:9668-9676. 2009
  • Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction.  48:9306-9312. 2009
  • Mutagenesis and evolution of sulfated antibodies using an expanded genetic code.  48:8891-8898. 2009
  • Resonance raman spectra of an o2-binding h-nox domain reveal heme relaxation upon mutation.  48:8568-8577. 2009
  • Prion proteins with pathogenic and protective mutations show similar structure and dynamics.  48:8120-8128. 2009
  • Functional dynamics of the folded ankyrin repeats of i kappa b alpha revealed by nuclear magnetic resonance.  48:8023-8031. 2009
  • Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals.  48:7698-7704. 2009
  • Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment.  48:7547-7555. 2009
  • Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.  48:7365-7372. 2009
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity.  48:7519-7524. 2009
  • Signal recognition particle (srp) and srp receptor: A new paradigm for multistate regulatory gtpases.  48:6696-6704. 2009
  • A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.  48:6288-6290. 2009
  • Synthesis of nitric oxide by the nos-like protein from deinococcus radiodurans: A direct role for tetrahydrofolate.  48:5483-5491. 2009
  • Crystal structures of cytochrome p450 2b4 in complex with the inhibitor 1-biphenyl-4-methyl-1h-imidazole: Ligand-induced structural response through alpha-helical repositioning.  48:4762-4771. 2009
  • Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.  48:3417-3424. 2009
  • Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris.  48:2643-2653. 2009
  • Chemical frustration in the protein folding landscape: Grand canonical ensemble simulations of cytochrome c.  48:2394-2402. 2009
  • Mapping the interactions of the p53 transactivation domain with the kix domain of cbp.  48:2115-2124. 2009
  • The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals.  48:1936-1944. 2009
  • Quantification of the vitamin D receptor-coregulator interaction.  48:1454-1461. 2009
  • Accommodation of two diatomic molecules in cytochrome bo(3): Insights into no reductase activity in terminal oxidases.  48:883-890. 2009
  • Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes.  48:820-826. 2009
  • Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism.  48:110-120. 2009
  • Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways.  48:10591-10600. 2009
  • Characterization of alkaline transitions in ferricytochrome c using carbon-deuterium infrared probes.  47:13470-13480. 2008
  • Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes.  47:13514-13523. 2008
  • The intrinsically disordered rnr inhibitor sml1 is a dynamic dimer.  47:13428-13437. 2008
  • The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster.  47:12740-12749. 2008
  • Two-dimensional combinatorial screening identifies specific 6 '-acylated kanamycin A- and 6 '-acylated neamine-RNA hairpin interactions.  47:12670-12679. 2008
  • Substrate-ligand interactions in Geobacillus stearothermophilus nitric oxide synthase.  47:12389-12397. 2008
  • The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.  47:12251-12253. 2008
  • Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains.  47:11793-11803. 2008
  • The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50.  47:11446-11456. 2008
  • Repair of o(6)-g-alkyl-o(6)-g interstrand cross-links by human o(6)-alkylguanine-DNA alkyltransferase.  47:10892-10903. 2008
  • Synthesis and characterization of new piperazine-type inhibitors for mitochondrial nadh-ubiquinone oxidoreductase (complex i).  47:10816-10826. 2008
  • Kinetic mechanism of protein arginine methyltransferase 1.  47:10420-10427. 2008
  • Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state.  47:9900-9910. 2008
  • Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.  47:9756-9770. 2008
  • Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm.  47:9456-9466. 2008
  • Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis.  47:9227-9233. 2008
  • Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.  47:7999-8006. 2008
  • Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis.  47:7782-7784. 2008
  • Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation.  47:7695-7705. 2008
  • Exploring the energy landscape of antibody-antigen complexes: Protein dynamics, flexibility, and molecular recognition.  47:7237-7247. 2008
  • Light activation of the LOV protein Vivid generates a rapidly exchanging dimer.  47:7012-7019. 2008
  • Sre1, an iron-modulated gata DNA-binding protein of iron-uptake genes in the fungal pathogen histoplasma capsulatum.  47:7274-7283. 2008
  • Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.  47:6969-6984. 2008
  • Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family.  47:6361-6369. 2008
  • Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidases.  47:4657-4665. 2008
  • Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.  47:3892-3899. 2008
  • Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.  47:3917-3925. 2008
  • Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1.  47:3076-3084. 2008
  • Nmr relaxation study of the complex formed between cbp and the activation domain of the nuclear hormone receptor coactivator actr.  47:1299-1308. 2008
  • Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?.  47:50-59. 2008
  • Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, gyc-88e, from drosophila.  46:15115-15122. 2007
  • Structural models for the KCNQ1 voltage-gated potassium channel.  46:14141-14152. 2007
  • Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxid.  46:13677-13683. 2007
  • Protein arginine methyltransferase 1: Positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis.  46:13370-13381. 2007
  • Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.  46:13019-13030. 2007
  • Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue.  46:12289-12297. 2007
  • Evidence that tRNA synthetase-directed proton transfer stops mistranslation.  46:12062-12070. 2007
  • Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome p4502b4.  46:11559-11567. 2007
  • An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance.  46:11223-11230. 2007
  • Biogenesis of the secretory granule: Chromogranin a coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.  46:10999-11012. 2007
  • Elucidation of the interleukin-15 binding site on its alpha receptor by NMR.  46:9453-9461. 2007
  • Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase.  46:9578-9585. 2007
  • Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.  46:8744-8752. 2007
  • Dimerization of the klenow fragment of escherichia coli DNA polymerase i is linked to its mode of DNA binding.  46:8085-8099. 2007
  • Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications.  46:7832-7843. 2007
  • Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms.  46:7196-7204. 2007
  • The structure of l-tyrosine 2,3-aminomutase from the c-1027 enediyne antitumor antibiotic biosynthetic pathway.  46:7205-7214. 2007
  • Protein arginine deiminase 4: Evidence for a reverse protonation mechanism.  46:6578-6587. 2007
  • The ND1 subunit constructs the inhibitor binding domain in bovine heart mitochondrial complex I.  46:6409-6416. 2007
  • Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation.  46:5552-5561. 2007
  • Functional characterization of the heterooligomeric ebrab multidrug efflux transporter of bacillus subtilis.  46:5218-5225. 2007
  • Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicing.  46:4861-4875. 2007
  • Alpha-synuclein multistate folding thermodynamics: Implications for protein misfolding and aggregation.  46:4499-4509. 2007
  • 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle.  46:3942-3951. 2007
  • Substrate tolerance of module 6 of the epothilone synthetase.  46:3385-3393. 2007
  • Structural basis for spinophilin-neurabin receptor interaction.  46:2333-2344. 2007
  • The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.  46:1503-1510. 2007
  • Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.  46:659-668. 2007
  • Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.  46:359-368. 2007
  • Functional interrogation of the kinome using nucleotide acyl phosphates.  46:350-358. 2007
  • Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.  46:145-155. 2007
  • A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.  45:15529-15540. 2006
  • Evidence for activation of tissue factor by an allosteric disulfide bond.  45:12020-12028. 2006
  • Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization.  45:11727-11736. 2006
  • Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): Discovery of phosphorylcholine derivatives of N-acyl ethanolamines.  45:11267-11277. 2006
  • Kinetic mechanism of RGS9-1 potentiation by R9AP.  45:10690-10697. 2006
  • Structural characterization of enterobactin hydrolase IroE.  45:10184-10190. 2006
  • Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand.  45:9434-9444. 2006
  • A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.  45:9007-9015. 2006
  • Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids.  45:9016-9022. 2006
  • Light chain of botulinum neurotoxin serotype A: Structural resolution of a catalytic intermediate.  45:8903-8911. 2006
  • Structural mobility in human manganese superoxide dismutase.  45:8209-8215. 2006
  • Carboxyl terminus of Helicobacter pylori alpha 1,3-fucosyltransferase determines the structure and stability.  45:8108-8116. 2006
  • EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate : ferredoxin oxidoreductase.  45:7122-7131. 2006
  • Identification of hydrophobic residues critical for DPP-IV dimerization.  45:7006-7012. 2006
  • Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B.  45:7162-7170. 2006
  • Discovery of different types of inhibition between the human and Thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives.  45:5695-5702. 2006
  • Interaction of α-and β-oligoarginine-acids and amides with anionic lipid vesicles: a mechanistic and thermodynamic study.  45:5817-5829. 2006
  • Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids.  45:4720-4726. 2006
  • Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.  45:4463-4473. 2006
  • Identification of Asp(174) and Asp(175) as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.  45:3835-3844. 2006
  • Structure of botulinurn neurotoxin type d light chain at 1.65 Å resolution: Repercussions for vamp-2 substrate specificity.  45:3255-3262. 2006
  • The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule.  45:3297-3306. 2006
  • Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation.  45:2537-2544. 2006
  • Heparin accelerates gelsolin amyloidogenesis.  45:2234-2242. 2006
  • Nmr-derived dynamic aspects of n-type inactivation of a kv channel suggest a transient interaction with the t1 domain.  45:1663-1672. 2006
  • Nmr solution structure of the peptide fragment 1-30, derived from unprocessed mouse doppel protein, in dhpc micelles.  45:159-166. 2006
  • Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation.  45:263-271. 2006
  • Partitioning conformational intermediates between competing refolding and aggregation pathways: Insights into transthyretin amyloid disease.  44:16612-16623. 2005
  • Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: Hydrodynamic and fluorescence anisotropy decay analyses.  44:16602-16611. 2005
  • Characterization of functional heme domains from soluble guanylate cyclase.  44:16266-16274. 2005
  • Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase.  44:16257-16265. 2005
  • Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.  44:16211-16220. 2005
  • The pathway by which the tetrameric protein transthyretin dissociates.  44:15525-15533. 2005
  • Nmr analyses of the activation of the arp2/3 complex by neuronal wiskott-aldrich syndrome protein.  44:15247-15256. 2005
  • Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library.  44:14845-14853. 2005
  • Investigation of the iron-sulfur cluster in mycobacterium tuberculosis APS reductase: Implications for substrate binding and catalysis.  44:14647-14657. 2005
  • Phosphorylation of aquaporin pvtip3;1 defined by mass spectrometry and molecular modeling.  44:14443-14454. 2005
  • Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B.  44:14486-14493. 2005
  • Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.  44:14143-14151. 2005
  • Chemoenzymatic synthesis of cryptophycin/arenastatin natural products.  44:13457-13466. 2005
  • Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from escherichia coli.  44:13553-13559. 2005
  • Proton release due to manganese binding and oxidation in modified bacterial reaction centers.  44:13266-13273. 2005
  • Biochemical characterization and crystal structure of a dim1 family associated protein: Dim2.  44:11997-12008. 2005
  • Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.  44:11525-11538. 2005
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues.  44:11428-11439. 2005
  • Kinetic characterization of protein arginine deiminase 4: A transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.  44:10570-10582. 2005
  • Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from naja atra venom that targets the BKCa channel.  44:10145-10152. 2005
  • Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.  44:10046-10053. 2005
  • Structure of the 1,4-bis(2 '-deoxyadenosin-N-6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.  44:10081-10092. 2005
  • Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: Linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation.  44:9833-9840. 2005
  • Crystal structure of botulinum neurotoxin type g light chain: Serotype divergence in substrate recognition.  44:9574-9580. 2005
  • Structure-based engineering of internal cavities in coiled-coil peptides.  44:9723-9732. 2005
  • Characterization of the membrane domain subunit nuok (nd4l) of the nadh-quinone oxidoreductase from escherichia coli.  44:9545-9554. 2005
  • Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice?.  44:9079-9085. 2005
  • Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: Implications for transthyretin amyloidosis.  44:9265-9274. 2005
  • Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction.  44:8989-8997. 2005
  • Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase.  44:7593-7601. 2005
  • Design of a redox-linked active metal site: manganese bound to bacterial reaction centers at a site resembling that of photosystem II.  44:7389-7394. 2005
  • Development of small designer aldolase enzymes: Catalytic activity, folding, and substrate specificity.  44:7583-7592. 2005
  • Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation.  44:4977-4983. 2005
  • S-nitrosation and regulation of inducible nitric oxide synthase.  44:4636-4647. 2005
  • The tertiary structure of the hairpin ribozyme is formed through a slow conformational search.  44:4870-4876. 2005
  • Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.  44:4196-4203. 2005
  • Variant of human enzyme sequesters reactive intermediate.  44:4216-4221. 2005
  • Expression and characterization of the catalytic domains of soluble guanylate cyclase: Interaction with the heme domain.  44:4083-4090. 2005
  • Characterization of the membrane domain subunit nuoj (nd6) of the nadh-quinone oxidoreductase from escherichia coli by chromosomal DNA manipulation.  44:3562-3571. 2005
  • Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras Codon 61 sequence.  44:3327-3337. 2005
  • Association of Sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly.  44:2800-2810. 2005
  • Enhanced binding of rnap ii ctd phosphatase fcp1 to rap74 following ck2 phosphorylation.  44:2732-2745. 2005
  • Understanding GFP chromophore biosynthesis: Controlling backbone cyclization and modifying post-translational chemistry.  44:1960-1970. 2005
  • Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.  44:1097-1105. 2005
  • Amino acid substitution and modification resulting from escherichia coli expression of recombinant plasmodium falciparum histidine-rich protein ii.  44:987-995. 2005
  • Heme binding to the histidine-rich protein ii from plasmodium falciparum.  44:979-986. 2005
  • Cbp/p300 taz1 domain forms a structured scaffold for ligand binding.  44:490-497. 2005
  • Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.  43:16046-16055. 2004
  • Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants.  43:15379-15392. 2004
  • Assignment of endogenous substrates to enzymes by global metabolite profiling.  43:14332-14339. 2004
  • Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus.  43:14128-14138. 2004
  • Nmr structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 m urea.  43:13937-13943. 2004
  • On the solution structure of the t4 sliding clamp (gp45).  43:12723-12727. 2004
  • Cytochrome rc(552), formed during expression of the truncated, thermus thermophilus cytochrome c(552) gene in the cytoplasm of escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl (spirographis) heme.  43:12162-12176. 2004
  • Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.  43:12090-12104. 2004
  • Isomerase-independent chaperone function of cyclophilin ensures aggregation prevention of adenosine kinase both in vitro and under in vivo conditions.  43:11862-11872. 2004
  • Mechanistic studies of a flavin-dependent thymidylate synthase.  43:10295-10301. 2004
  • Prion protein interaction with the c-terminal sh3 domain of grb2 studied using NMR and optical spectroscopy.  43:10393-10399. 2004
  • Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from vibrio cholerae and thermoanaerobacter tengcongensis.  43:10203-10211. 2004
  • In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display.  43:9265-9275. 2004
  • The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA.  43:8725-8734. 2004
  • Identification and characterization of a novel RNA binding protein that associates with the 5 '-untranslated region of the chloroplast psbA mRNA.  43:8541-8550. 2004
  • Comparison of anandamide transport in FAAH wild-type and knockout neurons: Evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake.  43:8184-8190. 2004
  • Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10.  43:8067-8076. 2004
  • Nickel superoxide dismutase structure and mechanism.  43:8038-8047. 2004
  • Transthyretin aggregation under partially denaturing conditions is a downhill polymerization.  43:7365-7381. 2004
  • Role of hydrogen bonding in the active site of human manganese superoxide dismutase.  43:7038-7045. 2004
  • Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin.  43:6519-6534. 2004
  • Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.  43:3518-3526. 2004
  • Subunit proximity in the h+-translocating nadh-quinone oxidoreductase probed by zero-length cross-linking.  43:3750-3755. 2004
  • Subunit exchange by CheA histidine kinases from the mesophile Escherichia coli and the thermophile Thermotoga maritima.  43:2228-2240. 2004
  • Mode of action for linear peptide inhibitors of hiv-1 gp120 interactions.  43:1928-1938. 2004
  • Crystal structure of the broadly cross-reactive hiv-1-neutralizing fab x5 and fine mapping of its epitope.  43:1410-1417. 2004
  • Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.  43:1171-1183. 2004
  • Nonrandom structure in the urea-unfolded escherichia coli outer membrane protein x (ompx).  43:860-869. 2004
  • Histone - DNA binding free energy cannot be measured in dilution-driven dissociation experiments.  43:736-741. 2004
  • Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.  43:374-383. 2004
  • Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant delta E-torsinA.  42:15333-15341. 2003
  • A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).  42:13193-13201. 2003
  • Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: Formation of a pterin radical is required for enzyme activity.  42:13287-13303. 2003
  • Transiently misacylated tRNA is a primer for editing of misactivated adenylates by class I aminoacyl-tRNA synthetases.  42:12989-12997. 2003
  • Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis.  42:12708-12718. 2003
  • Conformational change in the nadp(h) binding domain of transhydrogenase defines four states.  42:12143-12153. 2003
  • Reduction potentials of rieske clusters: Importance of the coupling between oxidation state and histidine protonation state.  42:12400-12408. 2003
  • Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: Trigger for microdomain/raft formation?.  42:12028-12037. 2003
  • Structure of avian aicar transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site.  42:10904-10914. 2003
  • Mechanisms of redox-coupled proton transfer in proteins: Role of the proximal proline in reactions of the 3fe-4s cluster in azotobacter vinelandii ferredoxin i.  42:10589-10599. 2003
  • Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor.  42:10619-10626. 2003
  • Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression.  42:9598-9608. 2003
  • Blmiii and bimiv nonribosornal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.  42:9731-9740. 2003
  • Oxidase domains in epothilone and bleomycin biosynthesis: Thiazoline to thiazole oxidation during chain elongation.  42:9722-9730. 2003
  • C5L2, a nonsignaling C5A binding protein.  42:9406-9415. 2003
  • Electrostatic tuning of ion conductance in potassium channels.  42:9263-9268. 2003
  • Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions.  42:8756-8761. 2003
  • High-resolution structure of the soluble, respiratory-type rieske protein from thermus thermophilus: Analysis and comparison.  42:7303-7317. 2003
  • Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes.  42:7348-7357. 2003
  • A new strategy for the site-specific modification of proteins in vivo.  42:6735-6746. 2003
  • D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?.  42:6656-6663. 2003
  • Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.  42:6043-6056. 2003
  • Characterization and topology of the membrane domain nqo10 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans.  42:4534-4543. 2003
  • Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling.  42:3997-4008. 2003
  • Site-specific mutations provide new insights into the origin of pH effects and alternative spectral forms in the photoactive yellow protein from Halorhodospira halophila.  42:3319-3325. 2003
  • A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis.  42:2916-2925. 2003
  • Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel.  42:2781-2789. 2003
  • Role of electrostatic interactions in PDZ domain ligand recognition.  42:2797-2805. 2003
  • Bifunctional abletadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations.  42:2700-2707. 2003
  • The proton-translocating nadh-quinone oxidoreductase in the respiratory chain: The secret unlocked.  42:2266-2274. 2003
  • Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins.  42:2137-2148. 2003
  • Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.  42:1969-1977. 2003
  • A molecular motor or a regulator? Dynamin's in a class of its own.  42:1369-1376. 2003
  • Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide.  42:1646-1651. 2003
  • The nd5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex i.  42:746-754. 2003
  • Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.  42:6370-6379. 2003
  • Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.  42:9335-9345. 2003
  • Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.  42:6363-6369. 2003
  • Probing backbone hydrogen bonds in the hydrophobic core of GCN4.  41:15676-15684. 2002
  • Structural insights into the avian aicar transformylase mechanism.  41:15505-15513. 2002
  • Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR.  41:14206-14215. 2002
  • Energetics of hydrogen bond networks in rna: Hydrogen bonds surrounding g+1 and u42 are the major determinants for the tertiary structure stability of the hairpin ribozyme.  41:14095-14102. 2002
  • Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine.  41:14232-14237. 2002
  • Breaking and re-forming the disulfide bond at the high-potential, respiratory-type rieske 2fe-2s center of thermus thermophilus: Characterization of the sulfhydryl state by protein-film voltammetry.  41:14054-14065. 2002
  • Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.  41:13915-13925. 2002
  • Activation of angiogenic signaling pathways by two human tRNA synthetases.  41:13344-13349. 2002
  • Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type iii (akrlc2).  41:13451-13459. 2002
  • A nonproteolytic function of the 19s regulatory subunit of the 26s proteasome is required for efficient activated transcription by human rna polymerase ii.  41:12798-12805. 2002
  • Crystal structures of transhydrogenase domain i with and without bound nadh.  41:12745-12754. 2002
  • Molecular hinges in protein folding: The urea-denatured state of apomyoglobin.  41:12681-12686. 2002
  • Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.  41:12569-12574. 2002
  • Biochemical characterization and structural analysis of a highly proficient cocaine esterase.  41:12297-12307. 2002
  • Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids.  41:12509-12519. 2002
  • Evidence that phospholipids play a key role in pre-beta apoa-i formation and high-density lipoprotein remodeling.  41:12538-12545. 2002
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.  41:11981-11989. 2002
  • Structural biology of viruses by the combination of electron cryomicroscopy and x-ray crystallography.  41:11517-11524. 2002
  • Probing the Tetrahymena group I ribozyme reaction in both directions.  41:11171-11183. 2002
  • Structure of a nitric oxide synthase heme protein from Bacillus subtilis.  41:11071-11079. 2002
  • Redox properties of the 2fe-2s center in the 24 kda (nqo2) subunit of nadh : Ubiquinone oxidoreductase (complex i).  41:10056-10069. 2002
  • Role of zymogenicity-determining residues of coagulation factor vii/viia in cofactor interaction and macromolecular substrate recognition.  41:9302-9309. 2002
  • SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.  41:9229-9236. 2002
  • Kinetic mechanism for human rho-kinase ii (rock-ii).  41:8948-8953. 2002
  • Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases.  41:8429-8437. 2002
  • Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine.  41:8113-8119. 2002
  • The amino terminus of opsin translocates "posttranslationally" as efficiently as cotranslationally.  41:7707-7715. 2002
  • Mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia: Role of the nucleotide positioning loop.  41:7001-7007. 2002
  • Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor.  41:6688-6696. 2002
  • Characterization of the membrane domain nqo11 subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans.  41:4377-4384. 2002
  • 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting.  41:3943-3951. 2002
  • Reactions catalyzed by the heme domain of inducible nitric oxide synthase: Evidence for the involvement of tetrahydrobiopterin in electron transfer.  41:3439-3456. 2002
  • Determinants of DNA mismatch recognition within the polymerase domain of the klenow fragment.  41:713-722. 2002
  • Probing ligand recognition in the decarboxylase antibody 21d8: Implications for the catalytic mechanism.  41:772-779. 2002
  • Role of the glutamyl alpha-carboxylate of the substrate glutathione in the catalytic mechanism of human glutathione transferase A1-1.  40:15835-15845. 2001
  • Conformational and dynamic characterization of the molten globule state of an apomyoglobin mutant with an altered folding pathway.  40:14459-14467. 2001
  • Crystal structure of ATP sulfurylase from the bacterial symbiont of the hydrothermal vent tubeworm Riftia pachyptila.  40:14509-14517. 2001
  • Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.  40:13538-13547. 2001
  • Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.  40:12826-12832. 2001
  • Long-range effects on calcium binding and conformational change in the n-domain of calmodulin.  40:12719-12726. 2001
  • Kinetic analysis of product inhibition in human manganese superoxide dismutase.  40:12051-12058. 2001
  • Aminoacyl-S-enzyme intermediates in β-hydroxylations and α,β-desaturations of amino acids in peptide antibiotics.  40:11651-11659. 2001
  • Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1.  40:11660-11669. 2001
  • An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.  40:11442-11452. 2001
  • Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: Insight into the chaotrope unfolding dichotomy.  40:11453-11459. 2001
  • Energetics and affinity of the histone octamer for defined DNA sequences.  40:10927-10933. 2001
  • Tertiary structure stability of the hairpin ribozyme in its natural and minimal forms: Different energetic contributions from a ribose zipper motif.  40:11211-11218. 2001
  • A comparative analysis of the immunological evolution of antibody 28B4.  40:10764-10773. 2001
  • Fluorescence correlation spectroscopy detects galanin receptor diversity on insulinoma cells.  40:10839-10845. 2001
  • Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate.  40:10655-10663. 2001
  • Backbone dynamics in dihydrofolate reductase complexes: Role of loop flexibility in the catalytic mechanism.  40:9846-9859. 2001
  • Symmetrical stabilization of bound Ca2+ ions in a cooperative pair of EF-hands through hydrogen bonding of coordinating water molecules in calbindin D-9k.  40:9887-9895. 2001
  • Application of cross-correlated NMR spin relaxation to the zinc-finger protein CRP2(LIM2): evidence for collective motions in LIM domains.  40:9596-9604. 2001
  • Evidence that ga111 protein is a target of the ga14 activation domain in the mediator.  40:9421-9427. 2001
  • Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.  40:8487-8498. 2001
  • Turn structures in cgrp c-terminal analogues promote stable arrangements of key residue side chains.  40:8317-8325. 2001
  • Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.  40:7351-7354. 2001
  • Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol.  40:7736-7745. 2001
  • Crystal structure of atp sulfurylase from penicillium chrysogenum: Insights into the allosteric regulation of sulfate assimilation.  40:6795-6804. 2001
  • Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2 '-o-methyl hexanucleotides.  40:6520-6526. 2001
  • Recognition elements for 5 ' exon substrate binding to the Candida albicans group I intron.  40:6507-6519. 2001
  • Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.  40:6107-6115. 2001
  • Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG.  40:5587-5592. 2001
  • The crystal structure of a fusagenic sperm protein reveals extreme surface properties.  40:5407-5413. 2001
  • Editing by a tRNA synthetase: DNA aptamer-induced translocation and hydrolysis of a misactivated amino acid.  40:4478-4483. 2001
  • Profiling serine hydrolase activities in complex proteomes.  40:4005-4015. 2001
  • NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding.  40:3561-3571. 2001
  • Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities.  40:2702-2711. 2001
  • Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.  40:2743-2753. 2001
  • A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking.  40:2580-2587. 2001
  • Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.  40:1937-1944. 2001
  • Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with cd4.  40:1662-1670. 2001
  • Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.  40:1265-1273. 2001
  • Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function.  40:1274-1283. 2001
  • Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy.  40:987-993. 2001
  • Crystal structure of the von Willebrand factor modulator botrocetin.  40:345-352. 2001
  • Escherichia coli lipa is a lipoyl synthase: In vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein.  39:15166-15178. 2000
  • A structure-based approach to a synthetic vaccine for hiv-1.  39:14377-14391. 2000
  • Role of residue phe(225) in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor viia.  39:14457-14463. 2000
  • Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron.  39:14269-14278. 2000
  • hsp70 interacting protein hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1.  39:14314-14321. 2000
  • Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein.  39:13478-13486. 2000
  • Dynamics of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor.  39:13356-13364. 2000
  • Kinetics and reactivity of the flavin and heme cofactors of cellobiose dehydrogenase from phanerochaete chrysosporium.  39:13595-13601. 2000
  • Helical junctions as determinants for rna folding: Origin of tertiary structure stability of the hairpin ribozyme.  39:12970-12978. 2000
  • Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.  39:12585-12594. 2000
  • Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid.  39:12485-12493. 2000
  • Changes in the apomyoglobin folding pathway caused by mutation of the distal histidine residue.  39:11227-11237. 2000
  • Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x.  39:11467-11476. 2000
  • Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.  39:10950-10957. 2000
  • Inhibition of soluble guanylate cyclase by odq.  39:10848-10854. 2000
  • Asymmetric DNA binding by a homodimeric bHLH protein.  39:9092-9098. 2000
  • Exploring the membrane domain of the reduced nicotinamide adenine dinucleotide-quinone oxidoreductase of paracoccus denitrificans: Characterization of the nqo7 subunit.  39:9411-9418. 2000
  • Errors from selective disruption of the editing center in a tRNA synthetase.  39:8180-8186. 2000
  • Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis.  39:7131-7137. 2000
  • Targeting a pneumocystis carinii group i intron with methylphosphonate oligonucleotides: Backbone charge is not required for binding or reactivity.  39:6991-7000. 2000
  • The conformation of apolipoprotein a-i in high-density lipoproteins is influenced by core lipid composition and particle size: A surface plasmon resonance study.  39:5712-5721. 2000
  • Alternative splicing of Wilms' tumor suppressor protein modulates DNA binding activity through isoform-specific DNA-induced conformational changes.  39:5341-5348. 2000
  • Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.  39:4608-4621. 2000
  • Interaction of soluble guanylate cyclase with yc-1: Kinetic and resonance raman studies.  39:4191-4198. 2000
  • Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1.  39:3141-3148. 2000
  • Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin.  39:2894-2901. 2000
  • Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase.  39:2208-2217. 2000
  • Crystal structure of adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum.  39:1613-1621. 2000
  • Protonation states and pH titration in the photocycle of photoactive yellow protein.  39:1100-1113. 2000
  • Conformational effects in biological catalysis: an antibody-catalyzed oxy-Cope rearrangement.  39:627-632. 2000
  • Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a.  39:592-598. 2000
  • Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme a reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition.  39:237-247. 2000
  • Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes.  39:183-193. 2000
  • Intramolecular activation of a Ca2+-dependent protein kinase is disrupted by insertions in the tether that connects the calmodulin-like domain to the kinase.  39:4004-4011. 2000
  • New insights into inhibitor design from the crystal structure and NMR studies of escherichia coli GAR and 10-formyl-5,8,10-trideazafolic acid.  38:16783-16793. 1999
  • Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase.  38:16898-16903. 1999
  • Determination of fe-ligand bond lengths and the fe-n-o bond angles in soybean ferrous and ferric nitrosylleghemoglobin alpha using multiple-scattering xafs analyses.  38:16491-16499. 1999
  • Thermodynamics of RNA-RNA duplexes with 2-or 4-thiouridines: implications for antisense design and targeting a group I intron.  38:16655-16662. 1999
  • Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex.  38:16359-16365. 1999
  • NMR observation of selected segments in a larger protein: Central-segment isotope labeling through intein-mediated ligation.  38:16040-16044. 1999
  • The C-terminal region of human glutathione transferase Al-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.  38:16268-16275. 1999
  • Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.  38:15689-15696. 1999
  • Identification of modified tryptophan residues in apolipoprotein b-100 derived from copper ion-oxidized low-density lipoprotein.  38:15903-15908. 1999
  • Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli.  38:15915-15926. 1999
  • The glycine residue in cyclic lactam analogues of galanin(1-16)-nh2 is important for stabilizing an n-terminal helix.  38:15295-15304. 1999
  • Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.  38:14810-14819. 1999
  • NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop.  38:14507-14514. 1999
  • Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding.  38:14338-14351. 1999
  • Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism.  38:14125-14130. 1999
  • Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate.  38:14363-14378. 1999
  • Dual photoactive species in Glu46Asp and Glu46Ala mutants of photoactive yellow protein: A pH-driven color transition.  38:13766-13772. 1999
  • Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.  38:13480-13490. 1999
  • The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions.  38:13560-13573. 1999
  • Efficient 50S ribosome-catalyzed peptide bond synthesis with an aminoacyl minihelix.  38:12080-12088. 1999
  • Role of tryptophan 161 in catalysis by human manganese superoxide dismutase.  38:11686-11692. 1999
  • Engineered recombinant factor vii q(217) variants with altered inhibitor specificities.  38:10940-10948. 1999
  • Tertiary structure stabilization promotes hairpin ribozyme ligation.  38:11040-11050. 1999
  • Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides.  38:10801-10807. 1999
  • Chemical and mutagenic investigations of fatty acid amide hydrolase: Evidence for a family of serine hydrolases with distinct catalytic properties.  38:9804-9812. 1999
  • Fast product formation and slow product release are important features in a hysteretic reaction mechanism of glutathione transferase T2-2.  38:9982-9991. 1999
  • Conformational changes of gp120 in epitopes near the ccr5 binding site are induced by cd4 and a cd4 miniprotein mimetic.  38:9405-9416. 1999
  • Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site.  38:9254-9263. 1999
  • Oxidized and reduced azotobacter vinelandii ferredoxin i at 1.4 Å resolution: Conformational change of surface residues without significant change in the 3fe-4s (+/0) cluster.  38:8228-8239. 1999
  • Selenomethionine-substituted thermus thermophilus cytochrome ba3: Characterization of the cu-a site by se and cuk-exafs.  38:7075-7084. 1999
  • Structural basis for antibody catalysis of a disfavored ring closure reaction.  38:7062-7074. 1999
  • An animal virus-derived peptide switches membrane morphology: Possible relevance to nodaviral transfection processes.  38:5328-5336. 1999
  • The coral-derived natural products eleutherobin and sarcodictyins a and b: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.  38:5490-5498. 1999
  • Characterization of the DNA binding properties of the bHLH domain of Deadpan to single and tandem sites.  38:5138-5146. 1999
  • Different adaptations of the same peptide motif for tRNA functional contacts by closely homologous tRNA synthetases.  38:4965-4971. 1999
  • Mutation of an active site residue in escherichia coli uracil-DNA glycosylase: Effect on DNA binding, uracil inhibition and catalysis.  38:4834-4845. 1999
  • Nmr solution structure of alpha-conotoxin imi and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors.  38:3874-3882. 1999
  • N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides.  38:3235-3245. 1999
  • Interaction of DNA polymerase i (klenow fragment) with DNA substrates containing extrahelical bases: Implications for proofreading of frameshift errors during DNA synthesis.  38:2661-2668. 1999
  • Regulation of the catalytic function of coagulation factor viia by a conformational linkage of surface residue glu 154 to the active site.  38:2745-2751. 1999
  • Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of camp-dependent protein kinase.  38:2367-2376. 1999
  • Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain.  38:1957-1966. 1999
  • Studying low-density lipoprotein-monoclonal antibody complexes using dynamic laser light scattering and analytical ultracentrifugation.  38:1284-1292. 1999
  • The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence.  38:596-604. 1999
  • Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate.  38:848-852. 1999
  • Spectroscopic characterization of the heme-binding sites in plasmodium falciparum histidine-rich protein 2.  38:16916-16924. 1999
  • Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: Implications for wild-type, V30M, and L55P amyloid fibril formation.  37:17851-17864. 1998
  • Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase.  37:16853-16862. 1998
  • Regeneration of the ferrous heme of soluble guanylate cyclase from the nitric oxide complex: Acceleration by thiols and oxyhemoglobin.  37:16898-16907. 1998
  • Characterization of interactions between a two-component response regulator, spo0f, and its phosphatase, rapb.  37:16538-16545. 1998
  • Molecular basis for p38 protein kinase inhibitor specificity.  37:16573-16581. 1998
  • Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19.  37:16270-16279. 1998
  • Resonance raman characterization of the heme domain of soluble guanylate cyclase.  37:16289-16297. 1998
  • Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 Å resolution.  37:15638-15646. 1998
  • Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase.  37:15503-15512. 1998
  • Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: Identification of the transmembrane domain as a site for oligomerization.  37:15177-15187. 1998
  • Structural and kinetic evidence for strain in biological catalysis.  37:14404-14409. 1998
  • Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 Å resolution: Self-hydroxylation of phe300 and the pterin-binding site.  37:13437-13445. 1998
  • The 0.78 Å structure of a serine protease: Bacillus lentus subtilisin.  37:13446-13452. 1998
  • Mechanism and utility of an RNA-cleaving DNA enzyme.  37:13330-13342. 1998
  • Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase.  37:12458-12464. 1998
  • New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: Photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant.  37:11563-11568. 1998
  • Solution structure of the N-terminal EGF-like domain from human factor VII.  37:10605-10615. 1998
  • A small, thermostable, and monofunctional chorismate mutase from the archeon Methanococcus jannaschii.  37:10062-10073. 1998
  • Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin.  37:10298-10306. 1998
  • NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist.  37:9169-9178. 1998
  • Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine.  37:9193-9202. 1998
  • A source of response regulator autophosphatase activity: The critical role of a residue adjacent to the spo0f autophosphorylation active site.  37:7725-7732. 1998
  • Structure and intramodular dynamics of the amino-terminal LIM domain from quail cysteine- and glycine-rich protein CRP2.  37:7127-7134. 1998
  • Characterization of the ubiquinone reduction site of mitochondrial complex i using bulky synthetic ubiquinones.  37:6436-6445. 1998
  • Characterization of y122f r2 of escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and x-ray crystallography.  37:5840-5848. 1998
  • Recognition properties of a sequence-specific DNA binding antibody.  37:6015-6022. 1998
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: Murine alpha 8 beta 1 binds to the rgd site in tenascin-c fragments, but not to native tenascin-c.  37:5464-5474. 1998
  • Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.  37:4722-4730. 1998
  • Deletion of amino acids glu146 -> arg160 in human apolipoprotein a-i (apoa-i-seattle) alters lecithin : Cholesterol acyltransferase activity and recruitment of cell phospholipid.  37:4863-4868. 1998
  • Probing the active site of human manganese superoxide dismutase: The role of glutamine 143.  37:4731-4739. 1998
  • Identification of histidine 105 in the beta 1 subunit of soluble guanylate cyclase as the heme proximal ligand.  37:4502-4509. 1998
  • Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of emp1.  37:3699-3710. 1998
  • Effect of redox state on the folding free energy of a thermostable electron-transfer metalloprotein: The cu-a domain of cytochrome oxidase from thermus thermophilus.  37:3172-3177. 1998
  • Recognition of sequence-directed DNA structure by the klenow fragment of DNA polymerase i.  37:1898-1904. 1998
  • Structural dynamics of hiv-1 rev and its complexes with rre and 5s rna.  37:1800-1809. 1998
  • Effects of mutations on the partitioning of DNA substrates between the polymerase and 3 '-5 ' exonuclease sites of DNA polymerase i (klenow fragment).  37:1513-1522. 1998
  • Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in bacillus subtilis.  37:1365-1375. 1998
  • Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions.  37:779-782. 1998
  • Localization of the heme binding region in soluble guanylate cyclase.  36:15959-15964. 1997
  • Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli.  36:14930-14938. 1997
  • Formation of n-delta-cyanoornithine from n-g-hydroxy-l-arginine and hydrogen peroxide by neuronal nitric oxide synthase: Implications for mechanism.  36:14465-14473. 1997
  • Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin.  36:13461-13472. 1997
  • A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: Crystal structure of spo0f from bacillus subtilis.  36:12739-12745. 1997
  • Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: Structures of the escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products.  36:12120-12137. 1997
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: Heme activation via reduction-gated exogenous ligand exchange.  36:12101-12119. 1997
  • An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.  36:11314-11322. 1997
  • Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.  36:11252-11260. 1997
  • Crystal structure of tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.  36:10666-10674. 1997
  • Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.  36:10696-10708. 1997
  • Kinetic mechanism for p38 map kinase.  36:10422-10427. 1997
  • Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism.  36:10517-10525. 1997
  • Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: Equilibria with high kinetic barriers.  36:10230-10239. 1997
  • High-resolution NMR structure and backbone dynamics of the bacillus subtilis response regulator, spoof: Implications for phosphorylation and molecular recognition.  36:10015-10025. 1997
  • Collagen-based structures containing the peptoid residue n-isobutylglycine (nleu): Conformational analysis of gly-nleu-pro sequences by h-1-NMR and molecular modeling.  36:8725-8732. 1997
  • Collagen-based structures containing the peptoid residue n-isobutylglycine (nleu): Synthesis and biophysical studies of gly-nleu-pro sequences by circular dichroism and optical rotation.  36:8716-8724. 1997
  • Anisotropic molecular rotational diffusion in n-15 spin relaxation studies of protein mobility.  36:7305-7312. 1997
  • Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase.  36:6739-6744. 1997
  • Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin.  36:5234-5244. 1997
  • Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.  36:5097-5103. 1997
  • Structural analysis of Z-Z DNA junctions with A:A and T:T mismatched base pairs by NMR.  36:4258-4267. 1997
  • Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters.  36:3056-3060. 1997
  • Kinetics of folding of the IgG binding domain of peptostreptoccocal protein L.  36:3373-3382. 1997
  • Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57.  36:2622-2636. 1997
  • Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack.  36:823-831. 1997
  • Why is CMP-ketodeoxyoctonate highly unstable?.  36:780-785. 1997
  • Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein.  36:8-14. 1997
  • Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase.  36:12337-12345. 1997
  • Reconstruction of quaternary structures of class II tRNA synthetases by rational mutagenensis of a conserved domain.  36:15041-15048. 1997
  • Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain.  35:13222-13230. 1996
  • Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme.  35:11693-11701. 1996
  • Mechanism and specificity of human α-1,3-fucosyltransferase V.  35:11183-11195. 1996
  • Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B.  35:10464-10471. 1996
  • A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug.  35:9995-10003. 1996
  • Structural studies of the proton-translocating nadh-quinone oxidoreductase (ndh-1) of paracoccus denitrificans: Identity, property, and stoichiometry of the peripheral subunits.  35:9120-9127. 1996
  • Regiospecificity of aminoglycoside phosphotransferase from enterococci and staphylococci (aph(3')-iiia).  35:8686-8695. 1996
  • Active site structure of Rieske-type proteins: electron nuclear double resonance studies of isotopically labeled phthalate dioxygenase from Pseudomonas cepacia and Rieske protein from Rhodobacter capsulatus and molecular modeling studies of a Rieske center.  35:7834-7845. 1996
  • Characterization of c415 mutants of neuronal nitric oxide synthase.  35:7772-7780. 1996
  • Conformational flexibility of three-way DNA junctions containing unpaired nucleotides.  35:7959-7967. 1996
  • Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.  35:7731-7742. 1996
  • Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance.  35:6375-6384. 1996
  • The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid.  35:6470-6482. 1996
  • Mutational analysis suggests the same design for editing activities of two tRNA synthetases.  35:5596-5601. 1996
  • Altering substrate specificity at the heme edge of cytochrome c peroxidase.  35:4858-4866. 1996
  • Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface.  35:4287-4297. 1996
  • C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase.  35:4139-4145. 1996
  • Water-soluble, recombinant cu-a-domain of the cytochrome ba(3) subunit ii from thermus thermophilus.  35:3387-3395. 1996
  • Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase.  35:3258-3262. 1996
  • A phosphotransferase activity of the bacillus subtilis sporulation protein spoof that employs phosphoramidate substrates.  35:2926-2933. 1996
  • Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from streptomyces lividans.  35:2332-2341. 1996
  • Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.  35:2316-2321. 1996
  • Association between the amino- and carboxyl-terminal halves of lactose permease is specific and mediated by multiple transmembrane domains.  35:2016-2021. 1996
  • Binding of nitric oxide and carbon monoxide to soluble guanylate cyclase as observed with resonance raman spectroscopy.  35:1540-1547. 1996
  • Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide.  35:1093-1099. 1996
  • Method for predicting the state of association of discretized protein models. Application to leucine zippers.  35:955-967. 1996
  • Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis.  35:608-615. 1996
  • Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR.  35:1-6. 1996
  • A mechanism for reducing entropic cost of induced fit in protein-RNA recognition.  35:8095-8102. 1996
  • Structure of a dicationic monoimidazole lexitropsin bound to DNA.  34:16654-16661. 1995
  • Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase.  34:6014-6019. 1995
  • The ferrous heme of soluble guanylate cyclase: Formation of hexacoordinate complexes with carbon monoxide and nitrosomethane.  34:16397-16403. 1995
  • Interaction between the escherichia-coli regulatory protein tyrr and DNA - a fluorescence footprinting study.  34:15802-15812. 1995
  • Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase.  34:15638-15645. 1995
  • Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes.  34:15813-15828. 1995
  • Exploring the role of the solvent in the denaturation of a protein - a molecular-dynamics study of the DNA-binding domain of the 434-repressor.  34:15057-15067. 1995
  • Heme stoichiometry of heterodimeric soluble guanylate cyclase.  34:14668-14674. 1995
  • Mechanism of inhibition of human-leukocyte elastase by beta-lactams .3. Use of electrospray-ionization mass-spectrometry and 2-dimensional NMR techniques to identify beta-lactam-derived e-i-complexes.  34:14344-14355. 1995
  • Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.  34:13527-13536. 1995
  • Species-specific microhelix aminoacylation by a eukaryotic pathogen tRNA synthetase dependent on a single base pair.  34:12489-12495. 1995
  • Dynamics of the dihydrofolate-reductase folate complex - catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features.  34:11037-11048. 1995
  • Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA.  34:11204-11210. 1995
  • Tissue factor residues lys(165) and lys(166) are essential for rapid formation of the quaternary complex of tissue-factor-center-dot-viia with xa-center-dot-tissue factor pathway inhibitor.  34:10867-10871. 1995
  • Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition.  34:10340-10349. 1995
  • Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe.  34:10560-10568. 1995
  • Proton sharing between cysteine thiols in Escherichia coli thioredoxin: implications for the mechanism of protein disulfide reduction.  34:10101-10105. 1995
  • Identification of apolipoprotein b100 polymorphisms that affect low-density-lipoprotein metabolism - description of a new approach involving monoclonal-antibodies and dynamic light-scattering.  34:9571-9580. 1995
  • Malonyl-coenzyme a-acyl carrier protein acyltransferase of streptomyces-glaucescens - a possible link between fatty-acid and polyketide biosynthesis.  34:9389-9402. 1995
  • The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the klenow fragment of escherichia-coli polymerase-i and bacteriophage-t4 DNA-polymerase.  34:9185-9192. 1995
  • Isolated RNA binding domain of a class I tRNA synthetase.  34:8896-8903. 1995
  • Gene synthesis, high-level expression, and mutagenesis of Thiobacillus ferrooxidans rusticyanin: His 85 is a ligand to the blue copper center.  34:6640-6648. 1995
  • Nonessential active-site residues modulate selenosubtilisins kinetic mechanism.  34:6616-6620. 1995
  • 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.  34:6278-6287. 1995
  • Energetic contributions and topographical organization of ligand-binding residues of tissue factor.  34:6310-6315. 1995
  • Nitric oxide complexes of inducible nitric oxide synthase: Spectral characterization and effect on catalytic activity.  34:5627-5634. 1995
  • Refinement of netropsin bound to DNA - bias and feedback in electron-density map interpretation.  34:4983-4993. 1995
  • Highly specific oxidative cross-linking of proteins mediated by a nickel-peptide complex.  34:4733-4739. 1995
  • Hydrogen peroxide-supported oxidation of ng-hydroxy-l-arginine by nitric oxide synthase.  34:1930-1941. 1995
  • Structure-function in escherichia-coli iron superoxide-dismutase - comparisons with the manganese enzyme from thermus-thermophilus.  34:1646-1660. 1995
  • X-ray-absorption spectroscopy of the iron site in escherichia-coli fe(iii) superoxide-dismutase.  34:1661-1668. 1995
  • Crystal-structure of C-T-C-T-C-G-A-G-A-G - implications for the structure of the Holliday junction.  34:1022-1029. 1995
  • Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry.  34:720-723. 1995
  • Optical studies of a bacterial photoreceptor protein, photoactive yellow protein, in single-crystals.  34:879-890. 1995
  • Comparison of the hydrogen exchange behavior of reduced and oxidized Escherichia coli thioredoxin.  34:611-619. 1995
  • Direct measurement of thermodynamic and kinetic-parameters of DNA triple-helix formation by fluorescence spectroscopy.  33:15329-15337. 1994
  • Characterization of neuronal nitric oxide synthase and a c415h mutant, purified from a baculovirus overexpression system.  33:14723-14732. 1994
  • Characterization of the inactivation of nitric oxide synthase by ng-methyl-l-arginine: Evidence for heme loss.  33:14784-14791. 1994
  • Complete chemical-structure of photoactive yellow protein - novel thioester-linked 4-hydroxycinnamyl chromophore and photocycle chemist.  33:14369-14377. 1994
  • Crystal-structure of a covalent DNA drug adduct - anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.  33:13593-13610. 1994
  • Projection structure of the chip28 water channel in lipid bilayer-membranes at 12 Å resolution.  33:12735-12740. 1994
  • Stabilizing and destabilizing effects of placing beta-branched amino-acids in protein alpha-helices.  33:12022-12031. 1994
  • Continuous in vitro evolution of bacteriophage RNA polymerase promoters.  33:11980-11986. 1994
  • Contribution of amino acid residue 208 in the hydrophobic binding site to the catalytic mechanism of human glutathione transferase A1-1.  33:11717-11723. 1994
  • Crystal-structure of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f at 2.2 Å resolution.  33:11699-11706. 1994
  • Melting of a DNA helix terminus within the active-site of a DNA-polymerase.  33:11971-11979. 1994
  • Factor viia residue arg(290) is required for efficient activation of the macromolecular substrate factor-x.  33:11631-11636. 1994
  • Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies.  33:11073-11078. 1994
  • Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin.  33:10646-10651. 1994
  • Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure.  33:9904-9911. 1994
  • Transient hydrogen-bonds identified on the surface of the NMR solution structure of hirudin.  33:9303-9310. 1994
  • Differences in pressure stability of the 3 components of cowpea mosaic-virus - implications for virus assembly and disassembly.  33:8339-8346. 1994
  • Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation.  33:8029-8034. 1994
  • Genetic identification of an autoinhibitor in CDPK, a protein kinase with a calmodulin-like domain.  33:7267-7277. 1994
  • Broad-spectrum aminoglycoside phosphotransferase type-iii from enterococcus - overexpression, purification, and substrate-specificity.  33:6936-6944. 1994
  • Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme.  33:5966-5973. 1994
  • The NMR structure of the pulmonary surfactant-associated polypeptide sp-c in an apolar solvent contains a valyl-rich alpha-helix.  33:6015-6023. 1994
  • Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states.  33:5636-5640. 1994
  • Region of a conserved sequence motif in a class II tRNA synthetase needed for transfer of an activated amino acid to an RNA substrate.  33:5312-5318. 1994
  • Type-III omega-agatoxins - a family of probes for similar binding-sites on L-type and N-type calcium channels.  33:5098-5108. 1994
  • Inactivation of interleukin-1-beta converting-enzyme by peptide (acyloxy)methyl ketones.  33:3934-3940. 1994
  • Small-molecule binding to an artificially created cavity at the active-site of cytochrome-c peroxidase.  33:3807-3818. 1994
  • Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs.  33:2741-2747. 1994
  • Spectroscopic characterization of cytochrome ba(3), a terminal oxidase from thermus-thermophilus - comparison of the a(3)/cu-b site to that of bovine cytochrome aa(3).  33:3128-3141. 1994
  • Site-directed mutagenesis of a catalytic antibody - an arginine and a histidine residue play key roles.  33:1994-2003. 1994
  • Control of the murine phosphofructokinase-a gene during muscle differentiation.  33:1771-1777. 1994
  • Mutational mapping of functional residues in tissue factor - identification of factor-vii recognition determinants in both structural modules of the predicted cytokine receptor homology domain.  33:1565-1572. 1994
  • Dynamics of a flexible loop in dihydrofolate-reductase from escherichia-coli and its implication for catalysis.  33:439-442. 1994
  • Expression of the 25-kilodalton iron-sulfur subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans.  33:494-499. 1994
  • Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate.  33:773-779. 1994
  • An RNA binding site in a tRNA synthetase with a reduced set of amino acids.  33:11040-11045. 1994
  • Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization.  33:14213-14220. 1994
  • Conformational distributions of a 4-way DNA junction revealed by time-resolved fluorescence resonance energy-transfer.  32:13852-13860. 1993
  • Triple aminoacylation specificity of a chimerized transfer RNA.  32:14053-14061. 1993
  • Structure and dynamics of the sialic-acid moiety of g(m3)-ganglioside at the surface of a magnetically oriented membrane.  32:13405-13413. 1993
  • Nmr evidence for multiple conformations in a highly helical model peptide.  32:13089-13097. 1993
  • A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va.  32:12656-12663. 1993
  • Characterization of a folding intermediate of apoplastocyanin trapped by proline isomerization.  32:12299-12310. 1993
  • Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization.  32:12128-12135. 1993
  • Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.  32:12119-12127. 1993
  • Tetracenomycin-f2 cyclase - intramolecular aldol condensation in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens.  32:11149-11154. 1993
  • Ng-methyl-l-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase.  32:9677-9685. 1993
  • Crystallographic analysis of C-C-A-A-G-C-T-T-G-G and its implications for bending in B-DNA.  32:8923-8931. 1993
  • Electrostatic calculations of side-chain pk(a) values in myoglobin and comparison with NMR data for histidines.  32:8045-8056. 1993
  • Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III.  32:7861-7865. 1993
  • Solution structure by 2D 1H-NMR of a chimeric peptide recognized by galanin and neuropeptide Y receptors.  32:7787-7798. 1993
  • Tetracenomycin f1-monooxygenase - oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens.  32:6656-6663. 1993
  • Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin.  32:6337-6347. 1993
  • Peptide models of protein folding initiation sites. 2. The G-H turn region of myoglobin acts as a helix stop signal.  32:6348-6355. 1993
  • Peptide models of protein folding initiation sites. 3. The G-H helical hairpin of myoglobin.  32:6356-6364. 1993
  • Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III.  32:5786-5791. 1993
  • Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation.  32:5267-5272. 1993
  • Designed replacement of an internal hydration water molecule in bpti - structural and functional implications of a glycine-to-serine mutation.  32:4564-4570. 1993
  • Disulfide bond isomerization in bpti and bpti(g36s) - an NMR-study of correlated mobility in proteins.  32:3571-3582. 1993
  • Assignment of h-1, n-15, and c-13 resonances, identification of elements of secondary structure and determination of the global fold of the DNA-binding domain of gal4.  32:2144-2153. 1993
  • Electrospray ionization mass-spectrometry as a mechanistic tool - mass of human-leukocyte elastase and a beta-lactam-derived e-i complex.  32:2031-2035. 1993
  • DNA sequencing of the 7 remaining structural genes of the gene-cluster encoding the energy-transducing nadh-quinone oxidoreductase of paracoccus-denitrificans.  32:968-981. 1993
  • Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using (15)N NMR relaxation measurements.  32:426-435. 1993
  • Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc).  32:32-37. 1993
  • C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation.  32:13026-13031. 1993
  • Comparison of the lysine binding functions of lipoprotein(a) and plasminogen.  32:13681-13687. 1993
  • Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.  32:12793-12801. 1993
  • Kinetics of intermolecular cleavage by hammerhead ribozymes.  31:12042-12054. 1992
  • Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution.  31:10310-10314. 1992
  • Magnetic circular-dichroism study of cytochrome-ba3 from thermus-thermophilus - spectral contributions from cytochrome-b and cytochrome-a3 and nanosecond spectroscopy of co photodissociation intermediates.  31:9376-9387. 1992
  • Structural and functional-characterization of the mutant escherichia-coli glutaredoxin(c14- s) and its mixed disulfide with glutathione.  31:9288-9293. 1992
  • Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro.  31:8654-8660. 1992
  • Functional-role of a mobile loop of escherichia-coli dihydrofolate-reductase in transition-state stabilization.  31:7826-7833. 1992
  • Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction.  31:7899-7907. 1992
  • Macrophage nitric oxide synthase: Relationship between enzyme-bound tetrahydrobiopterin and synthase activity.  31:7160-7165. 1992
  • Gene-cluster of the energy-transducing nadh-quinone oxidoreductase of paracoccus-denitrificans - characterization of 4 structural gene-products.  31:6925-6932. 1992
  • Mechanistic probes of n-hydroxylation of l-arginine by the inducible nitric oxide synthase from murine macrophages.  31:6822-6828. 1992
  • Nitric oxide synthase is a cytochrome p-450 type hemoprotein.  31:6627-6631. 1992
  • Studies of virus structure by laser raman-spectroscopy .35. Conformations, interactions, and thermostabilities of rna and proteins in bean pod mottle virus - investigation of solution and crystal-structures by laser raman-spectroscopy.  31:6673-6682. 1992
  • RNA tetraloops as minimalist substrates for aminoacylation.  31:4931-4936. 1992
  • Assignment of the aliphatic h-1 and c-13 resonances of the bacillus-subtilis glucose permease-iia domain using double-resonance and triple-resonance heteronuclear 3-dimensional NMR-spectroscopy.  31:4413-4425. 1992
  • Backbone dynamics of the bacillus-subtilis glucose permease-iia domain determined from n-15 NMR relaxation measurements.  31:4394-4406. 1992
  • Novel transfer RNAs that are active in Escherichia coli.  31:4157-4160. 1992
  • The antitumor agent cc-1065 inhibits helicase-catalyzed unwinding of duplex DNA.  31:3968-3975. 1992
  • Conformation and dynamics of an fab'-bound peptide by isotope-edited NMR-spectroscopy.  31:3862-3871. 1992
  • Importance of a conserved residue, aspartate-162, for the function of escherichia-coli aspartate transcarbamoylase.  31:3026-3032. 1992
  • Crystal-structures of aconitase with isocitrate and nitroisocitrate bound.  31:2735-2748. 1992
  • Immunogenic peptides corresponding to the dominant antigenic region alanine-597 to cysteine-619 in the transmembrane protein of simian immunodeficiency virus have a propensity to fold in aqueous solution.  31:1458-1463. 1992
  • Activation of methotrexate-alpha-alanine by carboxypeptidase-A monoclonal-antibody conjugate.  31:891-897. 1992
  • Solution structure of murine epidermal growth-factor determined by NMR-spectroscopy and refined by energy minimization with restraints.  31:236-249. 1992
  • Mechanistic studies of a tyrosine-dependent catalytic antibody.  30:9757-9761. 1991
  • Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120.  30:9187-9194. 1991
  • Opposite facial specificity for 2 hydroquinone epoxidases - (3-si,4-re)-2,5-dihydroxyacetanilide epoxidase from streptomyces ll-c10037 and (3-re,4-si)-2,5-dihydroxyacetanilide epoxidase from streptomyces mpp-3051.  30:8936-8944. 1991
  • Interaction of DNA with the klenow fragment of DNA-polymerase-i studied by time-resolved fluorescence spectroscopy.  30:8759-8770. 1991
  • Characterization of the 25-kilodalton subunit of the energy-transducing nadh ubiquinone oxidoreductase of paracoccus-denitrificans - sequence similarity to the 24-kilodalton subunit of the flavoprotein fraction of mammalian complex-i.  30:8678-8684. 1991
  • Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine.  30:8463-8470. 1991
  • Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B.  30:8395-8401. 1991
  • Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic-nucleotide phosphodiesterase from bovine brain.  30:7931-7940. 1991
  • Evidence for a "cysteine-histidine box" metal-binding site in an Escherichia coli aminoacyl-tRNA synthetase.  30:6970-6976. 1991
  • Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy.  30:6896-6907. 1991
  • The NMR structure of cyclosporine-a bound to cyclophilin in aqueous-solution.  30:6563-6574. 1991
  • The nadh-binding subunit of the energy-transducing nadh-ubiquinone oxidoreductase of paracoccus-denitrificans - gene cloning and deduced primary structure.  30:6422-6428. 1991
  • A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.  30:6097-6102. 1991
  • Use of recombinant-DNA derived human relaxin to probe the structure of the native protein.  30:6006-6013. 1991
  • Fluorescence anisotropy decay of ethidium bound to nucleosome core particles .2. The torsional motion of the DNA is highly constrained and sensitive to ph.  30:5304-5313. 1991
  • Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR.  30:4262-4268. 1991
  • Circular-dichroism and magnetic circular-dichroism of azotobacter-vinelandii ferredoxin-i.  30:3200-3209. 1991
  • Dynamics of mismatched base-pairs in DNA.  30:3271-3279. 1991
  • Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase.  30:2514-2518. 1991
  • Evidence for 2 interconverting protein isomers in the methotrexate complex of dihydrofolate-reductase from escherichia-coli.  30:2184-2191. 1991
  • Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca.  30:1957-1964. 1991
  • Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis.  30:1484-1490. 1991
  • Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor.  30:1682-1691. 1991
  • Assembly of a class I tRNA synthetase from products of an artificially split gene.  30:319-324. 1991
  • Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli.  30:5202-5209. 1991
  • Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA.  30:2635-2641. 1991
  • Recombinant expression, biochemical-characterization, and biological-activities of the human MGSA-gro protein.  29:10225-10233. 1990
  • Hazards and their exploitation in the applications of molecular biology to structure-function relationships.  29:9495-9502. 1990
  • Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: evidence for a unique conformation of bound folate.  29:9667-9677. 1990
  • Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase.  29:9212-9218. 1990
  • Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by (1)H NMR.  29:7828-7837. 1990
  • Crystal-structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and ctp or atp at 2.8-a resolution and neutral ph.  29:7702-7715. 1990
  • Structural consequences of effector binding to the t-state of aspartate carbamoyltransferase - crystal-structures of the unligated and atp-complexed and ctp-complexed enzymes at 2.6-a resolution.  29:7691-7701. 1990
  • Sequence-specific h-1-NMR assignments and determination of the secondary structure for the activation domain isolated from pancreatic procarboxypeptidase-b.  29:7515-7522. 1990
  • Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii.  29:6400-6405. 1990
  • Minimum secondary structure requirements for catalytic activity of a self-splicing group-I intron.  29:6534-6539. 1990
  • A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis.  29:6314-6322. 1990
  • Identification of the nadh-binding subunit of nadh-ubiquinone oxidoreductase of paracoccus-denitrificans.  29:5515-5520. 1990
  • Studies of virus structure by laser raman-spectroscopy .26. Structural studies of bean pod mottle virus, capsid, and rna in crystal and solution states by laser raman-spectroscopy.  29:5018-5026. 1990
  • Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy.  29:4129-4136. 1990
  • A nucleotide that enhances the charging of RNA minihelix sequence variants with alanine.  29:3621-3626. 1990
  • Receptor interconversion model of hormone action. 1. Purification of a factor involved in conferring estradiol binding properties to the estrogen receptor.  29:2685-2690. 1990
  • Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor.  29:2691-2698. 1990
  • Receptor interconversion model of hormone action. 3. Estrogen receptor mediated repression of reporter gene activity in A431 cells.  29:2699-2702. 1990
  • Cloning and expression of 3 rabbit kidney cDNAs encoding lauric acid omega-hydroxylases.  29:873-879. 1990
  • Characterization of the overall and internal dynamics of short oligonucleotides by depolarized dynamic light scattering and NMR relaxation measurements.  29:799-811. 1990
  • Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells.  28:9337-9343. 1989
  • Proteolytic fragments of the nicotinic acetylcholine receptor identified by mass spectrometry: implications for receptor topography.  28:9184-9191. 1989
  • Generation of a catalytic sequence-specific hybrid DNase.  28:8277-8286. 1989
  • Insertion of new sequences into the catalytic domain of an enzyme.  28:8479-8484. 1989
  • Characterization of the escherichia-coli transcription factor-delta-70 - localization of a region involved in the interaction with core rna-polymerase.  28:7728-7734. 1989
  • Stereospecific nuclear magnetic-resonance assignments of the methyl-groups of valine and leucine in the DNA-binding domain of the 434-repressor by biosynthetically directed fractional c-13 labeling.  28:7510-7516. 1989
  • Transfer of synthetic sialic-acid analogs to n-linked and o-linked glycoprotein glycans using 4 different mammalian sialytransferases.  28:7386-7392. 1989
  • (1)H NMR studies of the solution conformations of an analog of the C-peptide of ribonuclease A.  28:7059-7064. 1989
  • Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold.  28:7074-7087. 1989
  • Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution.  28:6800-6804. 1989
  • Redox protein electron-transfer mechanisms - electrostatic interactions as a determinant of reaction site in c-type cytochromes.  28:6318-6322. 1989
  • Electron nuclear double-resonance spectroscopy of n-15-enriched phthalate dioxygenase from pseudomonas-cepacia proves that 2 histidines are coordinated to the 2fe-2s rieske-type clusters.  28:4861-4871. 1989
  • Conformation of recombinant desulfatohirudin in aqueous-solution determined by nuclear magnetic-resonance.  28:4301-4312. 1989
  • Static and transient hydrogen-bonding interactions in recombinant desulfatohirudin studied by h-1 nuclear magnetic-resonance measurements of amide proton-exchange rates and ph-dependent chemical-shifts.  28:4312-4317. 1989
  • Multinuclear NMR studies of DNA hairpins. 1. Structure and dynamics of d(CGCGTTGTTCGCG).  28:2819-2831. 1989
  • Multinuclear NMR studies of DNA hairpins. 2. Sequence-dependent structural variations.  28:2831-2836. 1989
  • Parameters for the molecular recognition of transfer RNAs.  28:2747-2759. 1989
  • A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA.  28:2740-2746. 1989
  • Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase.  28:2577-2586. 1989
  • Complete sequence of the human-tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.  28:1755-1762. 1989
  • Conformational studies of d-(aaaaattttt)2 using constraints from nuclear overhauser effects and from quantitative-analysis of the cross-peak fine-structures in two-dimensional h-1 nuclear magnetic-resonance spectra.  28:1462-1471. 1989
  • Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo.  28:4942-4947. 1989
  • H-1-NMR studies of human c3a anaphylatoxin in solution - sequential resonance assignments, secondary structure, and global fold.  27:9139-9148. 1988
  • Characterization of [4Fe-4Se](2+)/(3+) high-potential iron-sulfur protein from Chromatium vinosum.  27:8712-8719. 1988
  • Macrophage oxidation of l-arginine to nitrite and nitrate: nitric oxide is an intermediate.  27:8706-8711. 1988
  • Modification of DNA dynamics by platinum drug-binding - a time-dependent fluorescence depolarization study of the interaction of cis-diamminedichloroplatinum (ii) and trans-diamminedichloroplatinum(ii) with DNA.  27:8599-8606. 1988
  • H-1-NMR studies of plastocyanin from scenedesmus-obliquus - complete sequence-specific assignment, secondary structure-analysis, and global fold.  27:7806-7816. 1988
  • The history, properties, and biological effects of cachectin.  27:7575-7582. 1988
  • Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding.  27:7167-7175. 1988
  • Morphoregulatory molecules.  27:3533-3543. 1988
  • Efficient synthesis of a supercoiled m1o DNA molecule containing a site specifically placed psoralen adduct and its use as a substrate for DNA-replication.  27:3210-3215. 1988
  • Bovine plasminogen activator inhibitor 1: specificity determinations and comparison of the active, latent, and guanidine-activated forms.  27:2911-2918. 1988
  • Purification and characterization of 2 types of nadh-quinone reductase from thermus-thermophilus hb-8.  27:2008-2013. 1988
  • Sequence-specific h-1-NMR assignments and identification of slowly exchanging amide protons in murine epidermal growth-factor.  27:2235-2243. 1988
  • Electron-transfer from cytochrome-b5 to iron and copper-complexes.  26:7102-7107. 1987
  • Electron paramagnetic resonance study of the active site of copper-substituted human glyoxalase I.  26:6779-6784. 1987
  • Solid-state n-15 NMR of oriented lipid bilayer bound gramicidin a'.  26:6621-6626. 1987
  • Amide proton-exchange in the alpha-amylase polypeptide inhibitor tendamistat studied by two-dimensional h-1 nuclear-magnetic-resonance.  26:6488-6493. 1987
  • Deoxyhexanucleotide containing a vinyl-chloride induced dna lesion, 1,n6-ethenoadenine - synthesis, physical characterization, and incorporation into a duplex bacteriophage-m13 genome as part of an amber codon.  26:5626-5635. 1987
  • Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.  26:3763-3768. 1987
  • Inhibition of nadh ubiquinone reductase-activity by n,n'-dicyclohexylcarbodiimide and correlation of this inhibition with the occurrence of energy-coupling site-1 in various organisms.  26:2822-2828. 1987
  • Effect of isomers of swainsonine on glycosidase activity and glycoprotein processing.  26:2502-2510. 1987
  • Multilayered vesicles prepared by reverse-phase evaporation - liposome structure and optimum solute entrapment.  26:17-29. 1987
  • Topography of the high-affinity lysine binding site of plasminogen as defined with a specific antibody probe.  25:6926-6933. 1986
  • Electron-transfer reactions between flavodoxin semiquinone and c-type cytochromes - comparisons between various flavodoxins.  25:6502-6507. 1986
  • Inactivation of plasminogen activator inhibitor by oxidants.  25:6351-6355. 1986
  • Characterization of a fragment of bovine von Willebrand factor that binds to platelets.  25:6325-6335. 1986
  • Nmr-studies of the complex between the decadeoxynucleotide d-(gcattaatgc)2 and a minor-groove-binding drug.  25:5902-5910. 1986
  • Purification of a benzo[a]pyrene binding protein by affinity chromatography and photoaffinity labeling.  25:4322-4329. 1986
  • Purification and characterization of three distinct glutathione transferases from mouse liver.  25:4119-4125. 1986
  • Binding of coagulation factor-XI to washed human-platelets.  25:3884-3890. 1986
  • Kinetic-studies of reduction of a 1-1 cytochrome-c flavodoxin complex by free flavin semiquinones and rubredoxin.  25:3318-3328. 1986
  • Multiple forms of ubiquitin-protein ligase - binding of activated ubiquitin to protein substrates.  25:3134-3138. 1986
  • Transient kinetics of reduction of blue copper proteins by free flavin and flavodoxin semiquinones.  25:3363-3370. 1986
  • Horseradish peroxidase catalyzed hydroxylations: Mechanistic studies.  25:2946-2951. 1986
  • Proton NMR studies of plastocyanin: assignment of aromatic and methyl group resonances from two-dimensional spectra.  25:2364-2374. 1986
  • Characterization of a second estrogen receptor species in chick oviduct.  25:2073-2081. 1986
  • Kinetics of electron-transfer between cytochromes-c' and the semiquinones of free flavin and clostridial flavodoxin.  25:1383-1390. 1986
  • Amide proton-exchange in proteins by ex1 kinetics - studies of the basic pancreatic trypsin-inhibitor at variable p2h and temperature.  24:7396-7407. 1985
  • Correlation in isolated nuclei of template-engaged RNA polymerase II, ovalbumin mRNA synthesis, and estrogen receptor concentrations.  24:1275-1280. 1985
  • Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase.  24:6840-6848. 1985
  • Individual amide proton exchange rates in thermally unfolded basic pancreatic trypsin inhibitor.  24:7407-7411. 1985
  • Resonance Raman spectra of extracellular ligninase: evidence for a heme active site similar to those of peroxidases.  24:3394-3397. 1985
  • The oligosaccharide moiety of the beta-1-adrenergic receptor from turkey erythrocytes has a biantennary, n-acetyllactosamine-containing structure.  24:3765-3770. 1985
  • Two catalytically distinct subforms of cytochrome P-450 3b as obtained from inbred rabbits.  24:7222-7226. 1985
  • Assignment of acyl chain resonances from membranes of mammalian-cells by two-dimensional NMR methods.  23:5895-5897. 1984
  • Modulation of the kinetics and the steady-state level of intermediates of mitochondrial coupled reactions by inhibitors and uncouplers.  23:1029-1036. 1984
  • Receptors for high molecular-weight kininogen on stimulated washed human-platelets.  23:6863-6869. 1984
  • Thiols in oxidative-phosphorylation - inhibition and energy-potentiated uncoupling by monothiol and dithiol modifiers.  23:2449-2455. 1984
  • Use of a monoclonal antibody specific for rabbit microsomal cytochrome P-450 3b to characterize the participation of this cytochrome in the microsomal 6 beta- and 16 alpha-hydroxylation of progesterone.  23:4598-4603. 1984
  • X-ray absorption studies of the Zn2+ site of glyoxalase I.  23:685-689. 1984
  • Identification of histidine and methionine residues in the active site of the human uterine progesterone receptor with the affinity labels 11 alpha- and 16 alpha-(bromoacetoxy)progesterone.  22:1729-1734. 1983
  • Interaction of human-plasma kallikrein and its light chain with C1 inhibitor.  22:4860-4866. 1983
  • Molecular and catalytic properties of glutathione transferase mu from human liver: an enzyme efficiently conjugating epoxides.  22:3610-3617. 1983
  • N-terminal amino-acid-sequences of the alpha-chains and beta-chains of hla-dr1 and hla-dr2 antigens.  22:185-188. 1983
  • Partial amino-acid-sequence of a rabbit immunoglobulin light chain of allotype-b5.  22:993-998. 1983
  • Potentiometric titrations and oxidation-reduction potentials of several iron superoxide dismutases.  22:624-627. 1983
  • Effects of highly purified estrogen receptors on gene transcription in isolated nuclei.  21:1781-1787. 1982
  • Fluorescence and nuclear relaxation enhancement studies of the binding of glutathione derivatives to manganese-reconstituted glyoxalase I from human erythrocytes. A model for the catalytic mechanism of the enzyme involving a hydrated metal ion.  21:4850-4857. 1982
  • Kinetics of cytochrome-b oxidation in antimycin-treated sub-mitochondrial particles.  21:6614-6618. 1982
  • Reversible inhibition of the mitochondrial ubiquinol cytochrome-c oxidoreductase complex (complex-iii) by ethoxyformic anhydride.  21:4777-4782. 1982
  • Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase.  21:2637-2644. 1982
  • Measurement of heme accessibility in soybean ferric leghemoglobin-a and its complexes by proton magnetic-relaxation.  20:587-594. 1981
  • Purification of a human progesterone receptor.  20:5557-5565. 1981
  • Stereochemical outcome of processing of fluorinated substrates by ATP citrate lyase and malate synthase.  20:3719-3723. 1981
  • C-13 nuclear magnetic-resonance relaxation studies of internal mobility of the polypeptide-chain in basic pancreatic trypsin-inhibitor and a selectively reduced analog.  19:5189-5196. 1980
  • C-13 nuclear magnetic-resonance studies of the selectively isotope-labeled reactive site peptide-bond of the basic pancreatic trypsin-inhibitor in the complexes with trypsin, trypsinogen, and anhydrotrypsin.  19:5711-5715. 1980
  • Cd-113 nuclear magnetic-resonance studies of cadmium-substituted derivatives of bovine superoxide-dismutase.  19:591-596. 1980
  • Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate.  19:1151-1160. 1980
  • Proton nuclear magnetic resonance and electron paramagnetic resonance studies on skeletal muscle actin indicate that the metal and nucleotide binding sites are separate.  19:5912-5916. 1980
  • Purification of plasminogen-activator from rous-sarcoma virus-transformed chick-embryo fibroblasts treated with the tumor promoter phorbol 12-myristate 13-acetate.  19:5463-5471. 1980
  • Creatine-kinase - nuclear magnetic-resonance and fluorescence evidence for interaction of adenosine 5'-diphosphate with aromatic residue(s).  18:5050-5055. 1979
  • Equilibrium and kinetic studies of binding of lens-culinaris lectin to rabbit erythrocytes by a quantitative fluorometric method.  17:5000-5005. 1978
  • Fluorinated substrate analogues as stereochemical probes of enzymatic reaction mechanisms.  17:5567-5575. 1978
  • High-field c-13 nuclear magnetic-resonance studies at 90.5 mhz of basic pancreatic trypsin-inhibitor.  17:2263-2269. 1978
  • Immunological detection of O6-methylguanine in alkylated DNA.  17:1896-1901. 1978
  • Individual assignments of methyl resonances in h-1 nuclear magnetic-resonance spectrum of basic pancreatic trypsin-inhibitor.  17:2253-2263. 1978
  • Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver.  17:2978-2984. 1978
  • Sequence of a rabbit anti-micrococcus-lysodeikticus antibody light chain.  17:4311-4317. 1978
  • Superoxide-dismutase, a study of electronic properties of copper and zinc by x-ray absorption spectroscopy.  17:1842-1846. 1978
  • Carbon-13 nuclear magnetic-resonance studies of binding of selectively 13C-enriched oxytocins to neurohypophyseal protein, bovine neurophysin-II.  16:4194-4198. 1977
  • Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase.  16:4678-4684. 1977
  • Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs.  16:5454-5460. 1977
  • Inhibition of an aminoacyl transfer RNA synthetase by a specific trinucleotide derived from the sequence of its cognate transfer RNA.  16:5461-5464. 1977
  • Novel-approach to water proton relaxation in paramagnetic ion macromolecule complexes.  16:250-254. 1977
  • Purification and characterization of pyridoxal 5'-phosphate dependent serine hydroxymethylase from lamb liver and its action upon beta-phenylserines.  16:5342-5350. 1977
  • Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy.  16:5061-5065. 1977
  • Studies of reactions of lamb liver serine hydroxymethylase with l-phenylalanine - kinetic isotope effects upon quinonoid intermediate formation.  16:5350-5354. 1977
  • Studies of reactions of substituted d,l-erythro-beta-phenylserines with lamb liver serine hydroxymethylase - effects of substituents upon de-aldolization step.  16:5355-5363. 1977
  • Comparison of isotope labeling patterns of purines in three specific transfer RNAs.  15:2800-2803. 1976
  • Rate of tritium labeling of specific purines in relation to nucleic acid and particularly transfer RNA conformation.  15:2791-2799. 1976
  • Sequence composition of template-active fraction of rat-liver chromatin.  15:2472-2483. 1976
  • 13-C nuclear magnetic resonance studies on the lipid organization in enveloped virions (vesicular stomatitis virus).  14:2841-2847. 1975
  • Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA.  14:2775-2780. 1975
  • Biophysical studies on the mechanism of quinacrine staining of chromosomes.  13:2937-2945. 1974
  • Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe.  13:1841-1852. 1974
  • Effects of abnormal base ionizations on Mg(++) binding to transfer ribonucleic acid as studied by a fluorescent probe.  13:1852-1861. 1974
  • Protein iodination with solid-state lactoperoxidase.  13:1014-1021. 1974
  • Discrimination between steady-state kinetic models of the mechanism of action of yeast glyoxalase I.  12:387-391. 1973
  • Human glomerular basement membrane. Selective solubilization with chaotropes and chemical and immunologic characterization of its components.  12:3260-3266. 1973
  • Observations on the oxidation-reduction properties of bovine erythrocyte superoxide dismutase.  12:4893-4899. 1973
  • The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119.  12:2096-2099. 1973
  • Amino acid sequence of rabbit pneumococcal antibody. I. Light-chain cysteine-containing peptides.  11:4978-4985. 1972
  • An investigation of specific interactions of deoxyribonucleic acid and lysine-rich (F1) histone preparations.  11:1422-1430. 1972
  • Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid.  11:642-646. 1972
  • Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid.  11:17-23. 1972
  • Isolation and proteolytic cleavage of the intact subunit of concanavalin a.  11:3233-3239. 1972
  • Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate.  11:1582-1589. 1972
  • Isolation and order of the cyanogen bromide fragments of concanavalin a.  10:3343-3347. 1971
  • Nanosecond relaxation processes in aqueous mononucleoside solutions.  10:4423-4433. 1971
  • Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation.  9:3143-3148. 1970
  • On the rate law and mechanism of the adenosine triphosphate-pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases.  9:480-489. 1970
  • Small angle x-ray scattering of a homogeneous gamm g-1 immunoglobulin.  9:211-219. 1970
  • Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits.  9:1195-1205. 1970
  • The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications.  9:3197-3205. 1970
  • The covalent structure of a human gamma g-immunoglobulin. 7. Amino acid sequence of heavy-chain cyanogen bromide fragments h1-h4.  9:3161-3170. 1970
  • The covalent structure of a human gamma g-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments h5-h7.  9:3171-3181. 1970
  • The covalent structure of a human gamma g-immunoglobulin. Ix. Assignment of asparaginyl and glutaminyl residues.  9:3181-3188. 1970
  • The covalent structure of a human gamma g-immunoglobulin. Vi. Amino acid sequence of the light chain.  9:3155-3161. 1970
  • The covalent structure of a human gamma g-immunoglobulin. X. Intrachain disulfide bonds.  9:3188-3196. 1970
  • Subtypes of rabbit kappa light polypeptide chains associated with the beta locus.  8:2712-2718. 1969
  • Chemical and immunochemical characterization of electrophoretic subfractions of rabbit gammag-immunoglobulin light chains with b4 allotypic specificity.  7:14-24. 1968
  • The covalent structure of a human gamma g-immunoglobulin. 3. Arrangement of the cyanogen bromide fragments.  7:1967-1972. 1968
  • The covalent structure of a human gamma g-immunoglobulin. 4. The interchain disulfide bonds.  7:1973-1982. 1968
  • The covalent structure of a human gamma g-immunoglobulin. I. Isolation and characterization of the whole molecule, the polypeptide chains, and the tryptic fragments.  7:1950-1958. 1968
  • The covalent structure of a human gamma g-immunoglobulin. Ii. Isolation and characterization of the cyanogen bromide fragments.  7:1959-1966. 1968
  • The covalent structure of a human gamma g-immunoglobulin. V. Partial amino acid sequence of the light chain.  7:1983-1994. 1968
  • The covalent structure of a human γG-immunoglobulin. V. Partial amino acid sequence of the light chain.  7:1983-1994. 1968
  • Fluorescence polarization of human gamma-g-immunoglobulins.  6:1437-1447. 1967
  • Fluorescent probes for conformational states of proteins. 3. The activation of chymotrypsinogen.  6:567-572. 1967
  • Fluorescent probes for conformational states of proteins. Ii. The binding of 2-p-toluidinylnaphthalene-6-sulfonate to alpha-chymotrypsin.  6:559-566. 1967
  • Fluorescent probes for conformational states of proteins. I. Mechanism of fluorescence of 2-p-toluidinylnaphthalene-6-sulfonate, a hydrophobic probe.  5:1908-1919. 1966
  • Physical and catalytic properties of tryptophanase from bacillus alvei.  5:3137-3142. 1966
  • Purification and some properties of tryptophanase from Bacillus alvei.  5:2229-2237. 1966
  • Optical rotatory dispersion of ribonuclease and ribonuclease-nucleotide complexes.  4:2687-2690. 1965
  • Resemblance of the gross arrangement of polypeptide chains in reconstituted and native gamma-globulins.  3:1120-1126. 1964
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Identity

International Standard Serial Number (ISSN)

  • 0006-2960

Electronic International Standard Serial Number (EISSN)

  • 1520-4995

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