recent publications

• academic article

  • Botkjaer, K. A., Deryugina, E. I., Dupont, D. M., Gardsvoll, H., Bekes, E. M., Thuesen, C. K., Chen, Z., Ploug, M., Quigley, J. P., Andreasen, P. A. Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism Molecular Cancer Research  2012 10:1532-1543  DOI:10.1158/1541-7786.mcr-12-0349  PMID:23038812  PMCID:PMC3528818
  • Bekes, E. M., Deryugina, E. I., Kupriyanova, T. A., Zajac, E., Botkjaer, K. A., Andreasen, P. A., Quigley, J. P. Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells Neoplasia  2011 13:806-821  DOI:10.1593/neo.11704  PMID:21969814  PMCID:PMC3182273
  • Botkjaer, K. A., Fogh, S., Bekes, E. C., Chen, Z., Blouse, G. E., Jensen, J. M., Mortensen, K. K., Huang, M. D., Deryugina, E., Quigley, J. P., Declerck, P. J., Andreasen, P. A. Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies Biochemical Journal  2011 438:39-51  DOI:10.1042/bj20110129  PMID:21635223
  • Blouse, G. E., Botkjaer, K. A., Deryugina, E., Byszuk, A. A., Jensen, J. M., Mortensen, K. K., Quigley, J. P., Andreasen, P. A. A novel mode of intervention with serine protease activity: targeting zymogen activation Journal of Biological Chemistry  2009 284:4647-4657  DOI:10.1074/jbc.M804922200  PMID:19047064  PMCID:PMC2640953
  • Conn, E. M., Botkjaer, K. A., Kupriyanova, T. A., Andreasen, P. A., Deryugina, E. I., Quigley, J. P. Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion American Journal of Pathology  2009 175:1638-1652  DOI:10.2353/ajpath.2009.090384  PMID:19729488  PMCID:PMC2751560