related to degree

• Kastrinsky, David, Ph.D. in Synthetic Organic Chemistry, Scripps Research 2000 - 2005
• Wolkenberg, Scott, Ph.D. in Chemistry, Scripps Research 1998 - 2003

authors

• Parrish, J. P.
• Kastrinsky, David
• Wolkenberg, Scott
• Igarashi, Y.
• Boger, Dale

publication date

• September 2003

journal

• Journal of the American Chemical Society  Journal

abstract

• Yatakemycin represents the newest and now most potent member of a class of naturally occurring antitumor compounds that includes CC-1065 and the duocarmycins, which derive their biological properties from a characteristic DNA alkylation reaction. Herein, the first description of the yatakemycin DNA alkylation properties is detailed, constituting the first such study of a naturally occurring "sandwiched" member of this class. Thus, the event, sequence selectivity, relative rate and efficiency, and reversibility of the DNA alkylation reaction of yatakemycin are described.

subject areas

• Alkylation
• Antineoplastic Agents
• DNA
• Indoles
• Kinetics
• Models, Molecular
• Pyrroles
• Stereoisomerism

International Standard Serial Number (ISSN)

• 0002-7863

Digital Object Identifier (DOI)

• 10.1021/ja035984h

PubMed ID

• 12952479

start page

• 10971

end page

• 10976

volume

• 125

issue

• 36