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DNA alkylation properties of yatakemycin

Academic Article
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Overview

related to degree

  • Kastrinsky, David, Ph.D. in Synthetic Organic Chemistry, Scripps Research 2000 - 2005
  • Wolkenberg, Scott, Ph.D. in Chemistry, Scripps Research 1998 - 2003

authors

  • Parrish, J. P.
  • Kastrinsky, David
  • Wolkenberg, Scott
  • Igarashi, Y.
  • Boger, Dale

publication date

  • September 2003

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Yatakemycin represents the newest and now most potent member of a class of naturally occurring antitumor compounds that includes CC-1065 and the duocarmycins, which derive their biological properties from a characteristic DNA alkylation reaction. Herein, the first description of the yatakemycin DNA alkylation properties is detailed, constituting the first such study of a naturally occurring "sandwiched" member of this class. Thus, the event, sequence selectivity, relative rate and efficiency, and reversibility of the DNA alkylation reaction of yatakemycin are described.

subject areas

  • Alkylation
  • Antineoplastic Agents
  • DNA
  • Indoles
  • Kinetics
  • Models, Molecular
  • Pyrroles
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja035984h

PubMed ID

  • 12952479
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Additional Document Info

start page

  • 10971

end page

  • 10976

volume

  • 125

issue

  • 36

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