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Direct database searching with MALDI-PSD spectra of peptides

Academic Article
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Overview

authors

  • Griffin, Patrick
  • MacCoss, M. J.
  • Eng, J. K.
  • Blevins, R. A.
  • Aaronson, J. S.
  • Yates III, John

publication date

  • 1995

journal

  • Rapid Communications in Mass Spectrometry  Journal

abstract

  • The analysis of matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) mass spectra of peptides by using the cross-correlation method for database searching is illustrated. MALDI-PSD mass spectra are shown to contain sufficient fragmentation information to uniquely identify the correct amino acid sequence from large protein databases (approximately 160,000 entries). A search employing the MALDI-PSD mass spectrum of a phosphorylated peptide that correctly identifies the amino acid sequence and the site of phosphorylation is also illustrated.

subject areas

  • Amino Acid Sequence
  • Databases, Factual
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Molecular Sequence Data
  • Peptides
  • Phosphopeptides
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Identity

International Standard Serial Number (ISSN)

  • 0951-4198

Digital Object Identifier (DOI)

  • 10.1002/rcm.1290091515

PubMed ID

  • 8652878
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Additional Document Info

start page

  • 1546

end page

  • 1551

volume

  • 9

issue

  • 15

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