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A requirement for two cell types for antibody formation in vitro

Academic Article
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Overview

authors

  • Mosier, Donald

publication date

  • 1967

journal

  • Science  Journal

abstract

  • A suspension of mouse spleen cells can be separated into two populations on the basis of their ability or inability to adhere to plastic dishes. It was found that both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro. Exposure of adherent cells to antigen for brief periods of time was sufficient to initiate a maximal in vitro response.

subject areas

  • Animals
  • Antibody Formation
  • Antigen-Antibody Reactions
  • Culture Techniques
  • Erythrocytes
  • Mice
  • Phagocytosis
  • Sheep
  • Spleen
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.158.3808.1573

PubMed ID

  • 6060362
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Additional Document Info

start page

  • 1573

end page

  • 1575

volume

  • 158

issue

  • 3808

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