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A comparison of t cell memory against the same antigen induced by virus versus intracellular bacteria

Academic Article
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Overview

authors

  • Ochsenbein, A. F.
  • Karrer, U.
  • Klenerman, P.
  • Althage, A.
  • Ciurea, A.
  • Shen, H.
  • Miller, J. F.
  • Whitton, J. Lindsay
  • Hengartner, H.
  • Zinkernagel, R. M.

publication date

  • August 1999

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV (rLM-NP(actA)) or only the immunodominant epitope of H-2(d) mice (rLM-NP(118-126)). Immunization with LCMV and rLM induced a long-lived increased CTL precursor (CTLp) frequency specific for the viral (NP(118-126)) and for the bacterial (LLO(91-99)) epitope, respectively. However, after infection with rLM memory, CTLs were less protective against an intravenous LCMV challenge infection than a comparable number of LCMV-induced memory T cells. LCMV, but not recombinant Listeria-induced memory T cells were able to protect against lethal choriomeningitis by LCMV or a subsequent peripheral infection with recombinant vaccinia virus expressing LCMV-NP. The protective memory after viral and after rLM immunization was paralleled by evidence of LCMV but not rLM antigen persistence on day 15 and 30 after vaccination. These results document a striking difference in protective T cell memory between viral and bacterial vaccines and indicate that rapid T cell-dependent immune protection correlates with antigen persistence.

subject areas

  • Animals
  • Antigens, Bacterial
  • Antigens, Viral
  • Bacterial Vaccines
  • Epitopes
  • Immunologic Memory
  • Listeria monocytogenes
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred BALB C
  • Nucleoproteins
  • Recombinant Proteins
  • T-Lymphocytes, Cytotoxic
  • Vaccines, Synthetic
  • Viral Vaccines
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.96.16.9293

PubMed ID

  • 10430936
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Additional Document Info

start page

  • 9293

end page

  • 9298

volume

  • 96

issue

  • 16

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