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Rab1b regulates vesicular transport between the endoplasmic-reticulum and successive golgi compartments

Academic Article
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Overview

authors

  • Plutner, H.
  • Cox, A. D.
  • Pind, S.
  • Khosravifar, R.
  • Bourne, J. R.
  • Schwaninger, R.
  • Der, C. J.
  • Balch, William E.

publication date

  • 1991

journal

  • Journal of Cell Biology  Journal

abstract

  • We report an essential role for the ras-related small GTP-binding protein rab1b in vesicular transport in mammalian cells. mAbs detect rab1b in both the ER and Golgi compartments. Using an assay which reconstitutes transport between the ER and the cis-Golgi compartment, we find that rab1b is required during an initial step in export of protein from the ER. In addition, it is also required for transport of protein between successive cis- and medial-Golgi compartments. We suggest that rab1b may provide a common link between upstream and downstream components of the vesicular fission and fusion machinery functioning in early compartments of the secretory pathway.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Biological Transport
  • Blotting, Western
  • Cell Compartmentation
  • Endoplasmic Reticulum
  • Fluorescent Antibody Technique
  • GTP-Binding Proteins
  • Golgi Apparatus
  • Intracellular Membranes
  • Liver
  • Rats
  • rab1 GTP-Binding Proteins
  • rab2 GTP-Binding Protein
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Identity

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.115.1.31

PubMed ID

  • 1918138
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Additional Document Info

start page

  • 31

end page

  • 43

volume

  • 115

issue

  • 1

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