recent publications
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academic article
- Green, V. A., Arbuthnot, P., Weinberg, M. S. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+T cells Virology Journal 2012 9:272 DOI:10.1186/1743-422x-9-272 PMID:23153325 PMCID:PMC3511259
- Taylor, S. H., Harmse, J., Arbuthnot, P., Van den Berg, F., Weinberg, M. S., Rey, M. E. C. Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR Biotechniques 2012 52:254-262 DOI:10.2144/0000113839 PMID:22482441
- Scott, T., Paweska, J. T., Arbuthnot, P., Weinberg, M. S. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs Antiviral Therapy 2012 17:643-656 DOI:10.3851/imp2073 PMID:22345363
- Saayman, S., Arbuthnot, P., Weinberg, M. S. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors Nucleic Acids Research 2010 38:6652-6663 DOI:10.1093/nar/gkq460 PMID:20525791 PMCID:PMC2965221
- Dyer, V., Ely, A., Bloom, K., Weinberg, M., Arbuthnot, P. tRNA(LYs3) promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs Biochemical and Biophysical Research Communications 2010 398:640-646 DOI:10.1016/j.bbrc.2010.06.122 PMID:20599752
- Saayman, S. M., Arbuthnot, P., Weinberg, M. S. Effective Pol III-expressed long hairpin RNAs targeted to multiple unique sites of HIV-1 Methods in Molecular Biology 2010 629:159-174 DOI:10.1007/978-1-60761-657-3_11 PMID:20387149
- Hean, J., Crowther, C., Ely, A., Ul Islam, R., Barichievy, S., Bloom, K., Weinberg, M. S., van Otterlo, W. A., de Koning, C. B., Salazar, F., Marion, P., Roesch, E. B., et al. Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs Artificial DNA, PNA & XNA 2010 1:17-26 DOI:10.4161/adna.1.1.11981 PMID:21687523 PMCID:PMC3109439
- Weinberg, M. S., Arbuthnot, P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection Genome Medicine 2010 2:28 DOI:10.1186/gm149 PMID:20429960 PMCID:PMC2873806
- Chattopadhyay, S., Ely, A., Bloom, K., Weinberg, M. S., Arbuthnot, P. Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles Biochemical and Biophysical Research Communications 2009 389:484-489 DOI:10.1016/j.bbrc.2009.09.004 PMID:19733548
- Barichievy, S., Saayman, S., Arbuthnot, P., Weinberg, M. S. RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV Current Topics in Medicinal Chemistry 2009 9:1065-1078 PMID:19860707
- Arbuthnot, P., Ely, A., Weinberg, M. S. Hepatic delivery of RNA interference activators for therapeutic application Current Gene Therapy 2009 9:91-103 PMID:19355867
- Saayman, S., Barichievy, S., Capovilla, A., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA PLoS One 2008 3:e2602 DOI:10.1371/journal.pone.0002602 PMID:18596982 PMCID:PMC2434202
- Barichievy, S., Saayman, S., Von Eije, K. J., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The inhibitory efficacy of RNA POL III-Expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat Oligonucleotides 2007 17:419-431 DOI:10.1089/oli.2007.0095 PMID:17896874
- Arbuthnot, P., Longshaw, V., Naidoo, T., Weinberg, M. S. Opportunities for treating chronic hepatitis B and C virus infection using RNA interference Journal of Viral Hepatitis 2007 14:447-459 DOI:10.1111/j.1365-2893.2006.00818.x PMID:17576386
- Weinberg, M. S., Ely, A., Barichievy, S., Crowther, C., Mufamadi, S., Carmona, S., Arbuthnot, P. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA Molecular Therapy 2007 15:534-541 DOI:10.1038/sj.mt.6300077 PMID:17213835
- Weinberg, M. S., Ely, A., Passman, M., Mufamadi, S. M., Arbuthnot, P. Effective anti-hepatitis B virus hammerhead ribozymes derived from multimeric precursors Oligonucleotides 2007 17:104-112 DOI:10.1089/oli.2006.0049 PMID:17461767
- Cave, E., Weinberg, M. S., Cilliers, T., Carmona, S., Morris, L., Arbuthnot, P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag AIDS Research and Human Retroviruses 2006 22:401-410 DOI:10.1089/aid.2006.22.401 PMID:16706616
- Carmona, S., Ely, A., Crowther, C., Moolla, N., Salazar, F. H., Marion, P. L., Ferry, N., Weinberg, M. S., Arbuthnot, P. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs Molecular Therapy 2006 13:411-421 DOI:10.1016/j.ymthe.2005.10.013 PMID:16337206
- Weinberg, M., Passman, M., Kew, M., Arbuthnot, P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells Journal of Hepatology 2000 33:142-151 DOI:10.1016/s0168-8278(00)80171-3 PMID:10905598
- Passman, M., Weinberg, M., Kew, M., Arbuthnot, P. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells Biochemical and Biophysical Research Communications 2000 268:728-733 DOI:10.1006/bbrc.2000.2209 PMID:10679273