recent publications

• academic article

  • Green, V. A., Arbuthnot, P., Weinberg, M. S. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+T cells Virology Journal  2012 9:272  DOI:10.1186/1743-422x-9-272  PMID:23153325  PMCID:PMC3511259
  • Taylor, S. H., Harmse, J., Arbuthnot, P., Van den Berg, F., Weinberg, M. S., Rey, M. E. C. Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR Biotechniques  2012 52:254-262  DOI:10.2144/0000113839  PMID:22482441
  • Scott, T., Paweska, J. T., Arbuthnot, P., Weinberg, M. S. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs Antiviral Therapy  2012 17:643-656  DOI:10.3851/imp2073  PMID:22345363
  • Saayman, S., Arbuthnot, P., Weinberg, M. S. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors Nucleic Acids Research  2010 38:6652-6663  DOI:10.1093/nar/gkq460  PMID:20525791  PMCID:PMC2965221
  • Dyer, V., Ely, A., Bloom, K., Weinberg, M., Arbuthnot, P. tRNA(LYs3) promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs Biochemical and Biophysical Research Communications  2010 398:640-646  DOI:10.1016/j.bbrc.2010.06.122  PMID:20599752
  • Saayman, S. M., Arbuthnot, P., Weinberg, M. S. Effective Pol III-expressed long hairpin RNAs targeted to multiple unique sites of HIV-1 Methods in Molecular Biology  2010 629:159-174  DOI:10.1007/978-1-60761-657-3_11  PMID:20387149
  • Hean, J., Crowther, C., Ely, A., Ul Islam, R., Barichievy, S., Bloom, K., Weinberg, M. S., van Otterlo, W. A., de Koning, C. B., Salazar, F., Marion, P., Roesch, E. B., et al. Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs Artificial DNA, PNA & XNA  2010 1:17-26  DOI:10.4161/adna.1.1.11981  PMID:21687523  PMCID:PMC3109439
  • Weinberg, M. S., Arbuthnot, P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection Genome Medicine  2010 2:28  DOI:10.1186/gm149  PMID:20429960  PMCID:PMC2873806
  • Chattopadhyay, S., Ely, A., Bloom, K., Weinberg, M. S., Arbuthnot, P. Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles Biochemical and Biophysical Research Communications  2009 389:484-489  DOI:10.1016/j.bbrc.2009.09.004  PMID:19733548
  • Barichievy, S., Saayman, S., Arbuthnot, P., Weinberg, M. S. RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV Current Topics in Medicinal Chemistry  2009 9:1065-1078  PMID:19860707
  • Arbuthnot, P., Ely, A., Weinberg, M. S. Hepatic delivery of RNA interference activators for therapeutic application Current Gene Therapy  2009 9:91-103  PMID:19355867
  • Saayman, S., Barichievy, S., Capovilla, A., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA PLoS One  2008 3:e2602  DOI:10.1371/journal.pone.0002602  PMID:18596982  PMCID:PMC2434202
  • Barichievy, S., Saayman, S., Von Eije, K. J., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The inhibitory efficacy of RNA POL III-Expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat Oligonucleotides  2007 17:419-431  DOI:10.1089/oli.2007.0095  PMID:17896874
  • Arbuthnot, P., Longshaw, V., Naidoo, T., Weinberg, M. S. Opportunities for treating chronic hepatitis B and C virus infection using RNA interference Journal of Viral Hepatitis  2007 14:447-459  DOI:10.1111/j.1365-2893.2006.00818.x  PMID:17576386
  • Weinberg, M. S., Ely, A., Barichievy, S., Crowther, C., Mufamadi, S., Carmona, S., Arbuthnot, P. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA Molecular Therapy  2007 15:534-541  DOI:10.1038/sj.mt.6300077  PMID:17213835
  • Weinberg, M. S., Ely, A., Passman, M., Mufamadi, S. M., Arbuthnot, P. Effective anti-hepatitis B virus hammerhead ribozymes derived from multimeric precursors Oligonucleotides  2007 17:104-112  DOI:10.1089/oli.2006.0049  PMID:17461767
  • Cave, E., Weinberg, M. S., Cilliers, T., Carmona, S., Morris, L., Arbuthnot, P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag AIDS Research and Human Retroviruses  2006 22:401-410  DOI:10.1089/aid.2006.22.401  PMID:16706616
  • Carmona, S., Ely, A., Crowther, C., Moolla, N., Salazar, F. H., Marion, P. L., Ferry, N., Weinberg, M. S., Arbuthnot, P. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs Molecular Therapy  2006 13:411-421  DOI:10.1016/j.ymthe.2005.10.013  PMID:16337206
  • Weinberg, M., Passman, M., Kew, M., Arbuthnot, P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells Journal of Hepatology  2000 33:142-151  DOI:10.1016/s0168-8278(00)80171-3  PMID:10905598
  • Passman, M., Weinberg, M., Kew, M., Arbuthnot, P. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells Biochemical and Biophysical Research Communications  2000 268:728-733  DOI:10.1006/bbrc.2000.2209  PMID:10679273