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A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons

Academic Article
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Overview

authors

  • Cherry, J. A.
  • Davis, Ronald

publication date

  • September 1995

journal

  • Journal of Neurobiology  Journal

abstract

  • The dunce (dnc) gene in Drosophila codes for a cyclic adenosine monophosphate-specific phosphodiesterase (PDE). Flies with a mutation at this locus exhibit severe deficits in learning and memory. We have begun to analyze the neural distribution of mammalian homologs of dnc in the mouse. Surprisingly, in situ hybridization and northern blotting using a probe specific for one of the four mammalian dnc homologs (mPDE2) reveals high levels of expression in the olfactory neuroepithelium. Anti-mPDE2 antibody confirms that this PDE protein is abundant in the axons and dendrites of the olfactory receptor neurons but is conspicuously absent from the cilia, where the initial events in olfactory signal transduction occur. Lower levels of mPDE2 were also detected throughout the brain and in the testis. These findings suggest an important modulatory role for mPDE2 in mammalian olfaction.

subject areas

  • Animals
  • Base Sequence
  • Blotting, Northern
  • Blotting, Western
  • Gene Expression Regulation
  • Genes, Insect
  • Immunohistochemistry
  • In Situ Hybridization
  • Learning
  • Memory
  • Mice
  • Molecular Sequence Data
  • Olfactory Receptor Neurons
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
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Research

keywords

  • CAMP
  • DUNCE
  • MOUSE
  • OLFACTION
  • PHOSPHOPHODIESTERASE
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Identity

International Standard Serial Number (ISSN)

  • 0022-3034

Digital Object Identifier (DOI)

  • 10.1002/neu.480280109

PubMed ID

  • 8586960
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Additional Document Info

start page

  • 102

end page

  • 113

volume

  • 28

issue

  • 1

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