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Autologous regulation of naive t cell homeostasis within the t cell compartment

Academic Article
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Overview

authors

  • Dummer, W.
  • Ernst, E.
  • LeRoy, E.
  • Lee, D. S.
  • Surh, Charles

publication date

  • February 2001

journal

  • Journal of Immunology  Journal

abstract

  • Naive T cells undergo spontaneous slow proliferation on adoptive transfer into syngeneic T cell (T)-deficient hosts. Recent work has shown that such "homeostatic" T cell proliferation is driven by MHC molecules loaded with self-peptides rather than foreign peptides. Because naive T cells in normal T-sufficient hosts remain in interphase despite continuous contact with self-MHC/peptide ligands, T cells apparently inhibit homeostatic proliferation of neighboring T cells. To address this, we have investigated the requirements necessary for "bystander" T cells to inhibit homeostatic proliferation of other T cells. Three key findings are reported. First, homeostatic proliferation of T cells only occurs in specific microenvironments, namely the T cell compartment of the secondary lymphoid tissues. Second, direct entry into T cell compartments is also required for bystander inhibition of homeostatic proliferation. Third, bystander inhibition is mediated largely by naive rather than activated/memory T cells and does not require proliferation or TCR ligation. These findings suggest that homeostasis of naive T cells is unlikely to be regulated through competition for systemic soluble factors or for specific stimulatory self-MHC/peptide ligands. Rather, the data favor mechanisms that involve competition for local non-MHC stimulatory factors or direct cell-to-cell interactions between the T cells themselves within the T cell compartment.

subject areas

  • Adoptive Transfer
  • Animals
  • Binding, Competitive
  • Cell Communication
  • Cell Division
  • Dendritic Cells
  • Histocompatibility Antigens Class II
  • Homeostasis
  • Interphase
  • Ligands
  • Lymph Nodes
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Spleen
  • Stromal Cells
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Regulatory
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 11160306
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Additional Document Info

start page

  • 2460

end page

  • 2468

volume

  • 166

issue

  • 4

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