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Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors

Academic Article
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Overview

authors

  • Nicklin, S. A.
  • Dishart, K. L.
  • Buening, H.
  • Reynolds, P. N.
  • Hallek, M.
  • Nemerow, Glen
  • Von Seggern, D. J.
  • Baker, A. H.

publication date

  • November 2003

journal

  • Cancer Letters  Journal

abstract

  • Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction in a panel of cancer cells. Six of twelve lines (C8161, PC-3, G-CCM, MKN-45, LnCAP and A549) were transduced, independently of native viral tropism. Furthermore the candidate cancer gene therapy promoter FLT-1 was active in three of these six cell lines. This offers the potential for dual targeting of selected cancer cells.

subject areas

  • Adenoviridae
  • Dependovirus
  • Genetic Engineering
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Neoplasms
  • Promoter Regions, Genetic
  • Proteinase Inhibitory Proteins, Secretory
  • Proteins
  • Receptors, Virus
  • Transcription, Genetic
  • Transduction, Genetic
  • Tumor Cells, Cultured
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Research

keywords

  • adeno-associated virus
  • adenovirus
  • gene therapy
  • promoter
  • targeting
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Identity

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2003.07.003

PubMed ID

  • 14607330
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Additional Document Info

start page

  • 165

end page

  • 173

volume

  • 201

issue

  • 2

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