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Altered antigen presentation in mice lacking H2-O

Academic Article
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Overview

authors

  • Liljedahl, M.
  • Winqvist, O.
  • Surh, Charles
  • Wong, P.
  • Ngo, K.
  • Teyton, Luc
  • Peterson, P. A.
  • Brunmark, A.
  • Rudensky, A. Y.
  • Fung-Leung, W. P.
  • Karlsson, L.

publication date

  • February 1998

journal

  • Immunity  Journal

abstract

  • HLA-DM catalyzes the release of MHC class II-associated invariant chain-derived peptides (CLIP) from class II molecules. Recent evidence has suggested that HLA-DO is a negative regulator of HLA-DM in B cells, but the physiological function of HLA-DO remains unclear. Analysis of antigen presentation by B cells from mice lacking H2-O (the mouse equivalent of HLA-DO), together with biochemical analysis using purified HLA-DO and HLA-DM molecules, suggests that HLA-DO/H2-O influences the peptide loading of class II molecules by limiting the pH range in which HLA-DM is active. This effect may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigens internalized by membrane immunoglobulin.

subject areas

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells
  • Antigens, Differentiation, B-Lymphocyte
  • B-Lymphocytes
  • Fluorescent Antibody Technique
  • Gene Targeting
  • HLA-D Antigens
  • Histocompatibility Antigens Class II
  • Hydrogen-Ion Concentration
  • Immunoglobulin G
  • Lymph Nodes
  • Mice
  • Mice, Mutant Strains
  • Peptides
  • Precipitin Tests
  • Spleen
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Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80475-6

PubMed ID

  • 9492004
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Additional Document Info

start page

  • 233

end page

  • 243

volume

  • 8

issue

  • 2

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