N-aryl-prolyl-dipeptides as potent antagonists of VLA-4

Academic Article
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publication date

  • August 2002

abstract

  • The design, synthesis, and biological evaluation of N-arylprolyl-dipeptide derivatives as small molecule VLA-4 antagonists is described. Potency against VLA-4 and alpha(4)beta(7) and rat pharmacokinetic evaluation revealed some advantages over the related N-(arylsulfonyl)-prolyl-dipeptide analogues.