Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation

Academic Article
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publication date

  • March 2004

abstract

  • A new methodology for the synthesis of heparin building blocks has been developed. We describe novel efficient routes to both L-iduronic acid and D-glucuronic acid acceptors. Glycosylation with thioglycosides donors gave corresponding disaccharides in a regio- and stereoselective fashion. An improved approach to synthesizing azido-glucose thioglycoside donor to render azido-sugar from mannose via nucleophilic substitution is described. [reaction: see text]