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Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates

Academic Article
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Overview

authors

  • Rowe, T.
  • Dascher, C.
  • Bannykh, S.
  • Plutner, H.
  • Balch, William E.

publication date

  • January 1998

journal

  • Science  Journal

abstract

  • Syntaxins are thought to function during vesicular transport as receptors on the target membrane and to contribute to the specificity of membrane docking and fusion by interacting with vesicle-associated receptors. Here, syntaxin 5 (Syn5) was shown to be an integral component of endoplasmic reticulum-derived transport vesicles. This pool, but not the target, Golgi-associated Syn5 pool, was essential for the assembly of vesicular-tubular pre-Golgi intermediates and the delivery of cargo to the Golgi. The requirement for vesicle-associated Syn5 in transport suggests a reevaluation of the basis for operation of the early secretory pathway.

subject areas

  • Adenosine Triphosphate
  • Animals
  • Antibodies
  • Biological Transport
  • Carrier Proteins
  • Cell Line
  • Endoplasmic Reticulum
  • Golgi Apparatus
  • Mannose-Binding Lectins
  • Membrane Fusion
  • Membrane Glycoproteins
  • Membrane Proteins
  • N-Ethylmaleimide-Sensitive Proteins
  • Organelles
  • Qa-SNARE Proteins
  • Qb-SNARE Proteins
  • Qc-SNARE Proteins
  • R-SNARE Proteins
  • Rats
  • SNARE Proteins
  • Vesicular Transport Proteins
  • Vesicular stomatitis Indiana virus
  • Viral Envelope Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.279.5351.696

PubMed ID

  • 9445473
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Additional Document Info

start page

  • 696

end page

  • 700

volume

  • 279

issue

  • 5351

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