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Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus

Academic Article
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Overview

authors

  • Wen, W. H.
  • Lin, M. G.
  • Su, C. Y.
  • Wang, S. Y.
  • Cheng, Y. S. E.
  • Fang, J. M.
  • Wong, Chi-Huey

publication date

  • August 2009

journal

  • Journal of Medicinal Chemistry  Journal

abstract

  • New anti-influenza agents of tetravalent zanamivir on a porphyrin scaffold were synthesized. These compounds are 10 to 100 times more potent in inhibiting influenza replications even though they are somewhat less potent in neuraminidase inhibition than the monomeric zanamivir. The enhanced anti-influenza activity is probably attributable to the additional viral inactivation by singlet oxygen due to sensitization of the porphyrin moiety, which is brought in close proximity of virus by the conjugated zanamivir in a manner resembling the "magic bullet" mechanism.

subject areas

  • Antiviral Agents
  • Enzyme Inhibitors
  • Neuraminidase
  • Orthomyxoviridae
  • Porphyrins
  • Virus Replication
  • Zanamivir
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm900515g

PubMed ID

  • 19522501
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Additional Document Info

start page

  • 4903

end page

  • 4910

volume

  • 52

issue

  • 15

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