recent publications
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academic article
- Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers Science 2015 349:aac4223 DOI:10.1126/science.aac4223 PMID:26089353 PMCID:PMC4498988
- Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., Joyce, M. G., Lingwood, D., Soto, C., Bailer, R. T., Ernandes, M. J., Kong, R., et al. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors Cell 2015 161:1280-1292 DOI:10.1016/j.cell.2015.05.007 PMID:26004070 PMCID:PMC4683157
- Munro, J. B., Gorman, J., Ma, X., Zhou, Z., Arthos, J., Burton, D. R., Koff, W. C., Courter, J. R., Smith III, A. B., Kwong, P. D., Blanchard, S. C., Mothes, W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions Science 2014 346:759-763 DOI:10.1126/science.1254426 PMID:25298114 PMCID:PMC4304640
- He, L., Sok, D., Azadnia, P., Hsueh, J., Landais, E., Simek, M., Koff, W. C., Poignard, P., Burton, D. R., Zhu, J. Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding Scientific Reports 2014 4:6778 DOI:10.1038/srep06778 PMID:25345460 PMCID:PMC4894419
- Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity 2014 40:657-668 DOI:10.1016/j.immuni.2014.04.009 PMID:24768347 PMCID:PMC4070425
- Zhou, T., Zhu, J., Yang, Y., Gorman, J., Ofek, G., Srivatsan, S., Druz, A., Lees, C. R., Lu, G., Soto, C., Stuckey, J., Burton, D. R., et al. Transplanting supersites of HIV-1 vulnerability PLoS One 2014 9:e99881 DOI:10.1371/journal.pone.0099881 PMID:24992528 PMCID:PMC4084637
- Zhou, T., Zhu, J., Wu, X., Moquin, S., Zhang, B., Acharya, P., Georgiev, I. S., Altae-Tran, H. R., Chuang, G. Y., Joyce, M. G., Kwon, Y. D., Longo, N. S., et al. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies Immunity 2013 39:245-258 DOI:10.1016/j.immuni.2013.04.012 PMID:23911655 PMCID:PMC3985390
- Amin, M. N., McLellan, J. S., Huang, W., Orwenyo, J., Burton, D. R., Koff, W. C., Kwong, P. D., Wang, L. X. Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies Nature Chemical Biology 2013 9:521-526 DOI:10.1038/nchembio.1288 PMID:23831758 PMCID:PMC3730851
- Pancera, M., Shahzad-ul-Hussan, S., Doria-Rose, N. A., McLellan, J. S., Bailer, R. T., Dai, K., Loesgen, S., Louder, M. K., Staupe, R. P., Yang, Y., Zhang, B., Parks, R., et al. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16 Nature Structural & Molecular Biology 2013 20:804-813 DOI:10.1038/nsmb.2600 PMID:23708607 PMCID:PMC4046252
- Koff, W. C., Burton, D. R., Johnson, P. R., Walker, B. D., King, C. R., Nabel, G. J., Ahmed, R., Bhan, M. K., Plotkin, S. A. Accelerating next-generation vaccine development for global disease prevention Science 2013 340:1232910 DOI:10.1126/science.1232910 PMID:23723240 PMCID:PMC4026248
- Zhu, J., Ofek, G., Yang, Y. P., Zhang, B. S., Louder, M. K., Lu, G., McKee, K., Pancera, M., Skinner, J., Zhang, Z. H., Parks, R., Eudailey, J., et al. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains Proceedings of the National Academy of Sciences of the United States of America 2013 110:6470-6475 DOI:10.1073/pnas.1219320110 PMID:23536288 PMCID:PMC3631616
- Pancera, M., Yang, Y. P., Louder, M. K., Gorman, J., Lu, G., McLellan, J. S., Stuckey, J., Zhu, J., Burton, D. R., Koff, W. C., Mascola, J. R., Kwong, P. D. N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function PLoS One 2013 8:e55701 DOI:10.1371/journal.pone.0055701 PMID:23431362 PMCID:PMC3576407
- Doria-Rose, N. A., Georgiev, I., O'Dell, S., Chuang, G. Y., Staupe, R. P., McLellan, J. S., Gorman, J., Pancera, M., Bonsignori, M., Haynes, B. F., Burton, D. R., Koff, W. C., et al. A short segment of the hiv-1 gp120 v1/v2 region is a major determinant of resistance to v1/v2 neutralizing antibodies Journal of Virology 2012 86:8319-8323 DOI:10.1128/jvi.00696-12 PMID:22623764 PMCID:PMC3421697
- Zhu, J., O'Dell, S., Ofek, G., Pancera, M., Wu, X., Zhang, B., Zhang, Z., NISC Comparative Sequencing Program, Mullikin, J. C., Simek, M., Burton, D. R., Koff, W. C., et al. Somatic populations of PGT135-137 HIV-1-neutralizing antibodies identified by 454 pyrosequencing and bioinformatics Frontiers in Microbiology 2012 3:315 DOI:10.3389/fmicb.2012.00315 PMID:23024643 PMCID:PMC3441199
- McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature 2011 480:336-343 DOI:10.1038/nature10696 PMID:22113616 PMCID:PMC3406929
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Wu, X. L., Zhou, T. Q., Zhu, J., Zhang, B. S., Georgiev, I., Wang, C., Chen, X. J., Longo, N. S., Louder, M., McKee, K., O'Dell, S., Perfetto, S., et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Science 2011 333:1593-1602 DOI:10.1126/science.1207532 PMID:21835983 PMCID:PMC3516815
- Reynolds, M. R., Weiler, A. M., Piaskowski, S. M., Kolar, H. L., Hessell, A. J., Weiker, M., Weisgrau, K. L., Leon, E. J., Rogers, W. E., Makowsky, R., McDermott, A. B., Boyle, R., et al. Macaques vaccinated with simian immunodeficiency virus sivmac239 delta nef delay acquisition and control replication after repeated low-dose heterologous siv challenge Journal of Virology 2010 84:9190-9199 DOI:10.1128/jvi.00041-10 PMID:20592091 PMCID:PMC2937616
- Pejchal, R., Walker, L. M., Stanfield, R. L., Phogat, S. K., Koff, W. C., Poignard, P., Burton, D. R., Wilson, I. A. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 Proceedings of the National Academy of Sciences of the United States of America 2010 107:11483-11488 DOI:10.1073/pnas.1004600107 PMID:20534513 PMCID:PMC2895122
- Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., Forthal, D. N., Koff, W. C., Poignard, P., Watkins, D. I., Burton, D. R. Broadly neutralizing monoclonal antibodies 2f5 and 4e10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus shivba-l Journal of Virology 2010 84:1302-1313 DOI:10.1128/jvi.01272-09 PMID:19906907 PMCID:PMC2812338
- Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., Lehrman, J. K., Priddy, F. H., et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target Science 2009 326:285-289 DOI:10.1126/science.1178746 PMID:19729618 PMCID:PMC3335270
- Simek, M. D., Rida, W., Priddy, F. H., Pung, P., Carrow, E., Laufer, D. S., Lehrman, J. K., Boaz, M., Tarragona-Fiol, T., Miiro, G., Birungi, J., Pozniak, A., et al. Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm Journal of Virology 2009 83:7337-7348 DOI:10.1128/jvi.00110-09 PMID:19439467 PMCID:PMC2704778
- Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I., Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers PLoS Pathogens 2009 5:e1000433 DOI:10.1371/journal.ppat.1000433 PMID:19436712 PMCID:PMC2674935
- Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., et al. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus Journal of Experimental Medicine 2008 205:2537-2550 DOI:10.1084/jem.20081524 PMID:18838548 PMCID:PMC2571929
- Watkins, D. I., Burton, D. R., Kallas, E. G., Moore, J. P., Koff, W. C. Nonhuman primate models and the failure of the merck hiv-1 vaccine in humans Nature Medicine 2008 14:617-621 DOI:10.1038/nm.f.1759 PMID:18535579 PMCID:PMC3697853
- Koff, W. C., Johnson, P. R., Watkins, D. I., Burton, D. R., Lifson, J. D., Hasenkrug, K. J., McDermott, A. B., Schultz, A., Zamb, T. J., Boyle, R., Desrosiers, R. C. HIV vaccine design: Insights from live attenuated siv vaccines Nature Immunology 2006 7:19-23 DOI:10.1038/ni1296 PMID:16357854