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Can receptor editing play an important role in normal b-cell development?

Academic Article
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Overview

authors

  • Nemazee, David

publication date

  • April 1996

journal

  • Journal of Autoimmunity  Journal

abstract

  • B-cells bearing in-frame light chain rearrangements often continue to rearrangement light chain genes, in apparent contradiction to the rules of allelic exclusion. The potential role of B-cell receptor self-reactivity in this process is discussed in the context of the possible efficiency of rescue of the autoreactive cells and the observed high frequency of peripheral B-cells that rearrange only a single light chain locus.

subject areas

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Gene Rearrangement, B-Lymphocyte, Light Chain
  • Receptors, Antigen, B-Cell
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Research

keywords

  • B lymphocyte
  • allelic exclusion
  • immune tolerance
  • immunoglobulin genes
  • receptor editing
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Identity

International Standard Serial Number (ISSN)

  • 0896-8411

Digital Object Identifier (DOI)

  • 10.1006/jaut.1996.0032

PubMed ID

  • 8738971
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Additional Document Info

start page

  • 259

end page

  • 261

volume

  • 9

issue

  • 2

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