Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Selected mutants of mouse hepatitis-virus type-4 (jhm-strain) induce different cns diseases - pathobiology of disease induced by wild-type and mutant-ts8 and mutant-ts15 in balb/c and sjl/j mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Knobler, R. L.
  • Tunison, L. A.
  • Lampert, P. W.
  • Oldstone, Michael

publication date

  • 1982

journal

  • American Journal of Pathology  Journal

abstract

  • The model system of central nervous system (CNS) disease induced by mouse hepatitis virus type 4 (MHV-4) is explored by comparison of wild type (wt) MHV-4 and two temperature-sensitive (ts) mutants, designated ts8 and ts15, in BALB/c and SJL/J mice. In BALB/c mice, 3 plaque-forming units (PFU) of wt MHV-4 given intracerebrally caused fatal encephalomyelitis in all mice by 7 days after infection, with spread of virus outside the CNS, especially to liver. In SJL/J mice, 3 PFU of wt virus was cleared within 2-3 days, with little spread, and up tp 100 PFU failed to cause fatal encephalomyelitis. However, larger amounts of virus, like 1000 PFU, caused fatal encephalomyelitis in SJL/J mice. In contrast, 10(4) PFU of MHV-4 ts8 did not cause death in either BALB/c or SJL/J mice, and persisted in the CNS of both strains while retaining its ts phenotype. There was significatnly less spread of virus outside the CNS. BALB/c mice usually showed demyelination, remyelination, and recurrent demyelination with ts8, while SJL/J mice only rarely had lesions. Intracerebral inoculation with 10(4) PFU of MHV-4 ts15 was associated with a persistent infection in CNS and liver of BALB/c mice; however, only occasional demyelination and hepatic lesions occurred. TS15 did not cause death in either BALB/c or SJL/J mice and did not cause histopathologic injury in SJL/J mice.

subject areas

  • Animals
  • Antigens, Viral
  • Central Nervous System
  • Central Nervous System Diseases
  • Demyelinating Diseases
  • Encephalitis
  • Liver
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • Murine hepatitis virus
  • Muscles
  • Mutation
  • Oligodendroglia
  • Spleen
  • Thymus Gland
scroll to property group menus

Identity

PubMed Central ID

  • PMC1916093

International Standard Serial Number (ISSN)

  • 0002-9440

PubMed ID

  • 6291396
scroll to property group menus

Additional Document Info

start page

  • 157

end page

  • 168

volume

  • 109

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support