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Dedifferentiation of lineage-committed cells by a small molecule

Academic Article
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Overview

related to degree

  • Chen, Shuibing, Ph.D. in Chemistry, Scripps Research 2002 - 2006
  • Wu, Xu, Ph.D. in Chemistry, Scripps Research 2001 - 2004

authors

  • Chen, Shuibing
  • Zhang, Qinghai
  • Wu, Xu
  • Schultz, Peter
  • Ding, Sheng

publication date

  • 2004

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Combinatorial libraries were screened for molecules that induce mouse myogenic lineage committed cells to dedifferentiate in vitro. A 2,6-disubstituted purine, reversine, was discovered that induces lineage reversal of C2C12 cells to become multipotent progenitor cells which can redifferentiate into osteoblasts and adipocytes. This and other such molecules are likely to provide new insights into the molecular mechanisms that control cellular dedifferentiation and may ultimately be useful to in vivo stem cell biology and therapy.

subject areas

  • Adipocytes
  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Mice
  • Molecular Weight
  • Morpholines
  • Myoblasts
  • Osteocytes
  • Purines
  • Stem Cells
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Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja037390k

PubMed ID

  • 14719906
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Additional Document Info

start page

  • 410

end page

  • 411

volume

  • 126

issue

  • 2

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