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RNA splicing contributes to the generation of mature mRNAs of Borna disease virus, a non-segmented negative strand RNA virus

Academic Article
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Overview

authors

  • Cubitt, B.
  • Oldstone, C.
  • Valcarcel, J.
  • de la Torre, Juan

publication date

  • 1994

journal

  • Virus Research  Journal

abstract

  • We recently demonstrated that Borna disease virus (BDV) has a negative non-segmented single stranded (NNS) RNA genome, whose organization is similar to that of other members of the Mononegavirales order. However, we have also documented that in contrast to the rest of the NNS-RNA animal viruses, BDV replication and transcription occur in the nucleus of infected cells. Here, we provide evidence that BDV uses the host nuclear splicing machinery to generate some of the viral mRNAs, representing the first documentation of RNA splicing in NNS-RNA animal viruses. Possible implications of RNA splicing for the regulation of BDV gene expression are discussed.

subject areas

  • Base Sequence
  • Borna disease virus
  • Cell Nucleus
  • DNA, Complementary
  • Gene Expression Regulation, Viral
  • Molecular Sequence Data
  • Open Reading Frames
  • Polymerase Chain Reaction
  • RNA Splicing
  • RNA, Messenger
  • RNA, Viral
  • Virus Replication
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Research

keywords

  • BORNA DISEASE VIRUS
  • NONSEGMENTED NEGATIVE STRAND RNA VIRUS
  • RNA SPLICING
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Identity

International Standard Serial Number (ISSN)

  • 0168-1702

Digital Object Identifier (DOI)

  • 10.1016/0168-1702(94)90120-1

PubMed ID

  • 7831966
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Additional Document Info

start page

  • 69

end page

  • 79

volume

  • 34

issue

  • 1

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