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Transition from moderate to excessive drug intake: Change in hedonic set point

Academic Article
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Overview

authors

  • Ahmed, S. H.
  • Koob, George

publication date

  • October 1998

journal

  • Science  Journal

abstract

  • Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction.

subject areas

  • Animals
  • Behavior, Addictive
  • Cocaine
  • Cocaine-Related Disorders
  • Dose-Response Relationship, Drug
  • Drug Tolerance
  • Male
  • Rats
  • Rats, Wistar
  • Reinforcement (Psychology)
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.282.5387.298

PubMed ID

  • 9765157
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Additional Document Info

start page

  • 298

end page

  • 300

volume

  • 282

issue

  • 5387

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