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ACS Chemical Biology

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articles

  • A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues.  15:1820-1825. 2020
  • Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.  15:1340-1348. 2020
  • 3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling.  15:878-883. 2020
  • Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells.  15:871-877. 2020
  • Cell-Based Ligand Discovery for the ENL YEATS Domain.  15:895-903. 2020
  • Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate.  15:849-855. 2020
  • hFUT1-Based Live-Cell Assay To Profile α1-2-Fucoside-Enhanced Influenza Virus A Infection.  15:819-823. 2020
  • The impact of sustained immunization regimens on the antibody response to oligomannose glycans.  15:789-798. 2020
  • Integrative X-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity.  15:575-586. 2020
  • Structure-specific cleavage of an RNA repeat expansion with a dimeric small molecule is advantageous over sequence-specific recognition by an oligonucleotide.  15:485-493. 2020
  • An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses.  15:2060-2069. 2020
  • Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity.  15:2031-2040. 2020
  • Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation.  15:2382-2394. 2020
  • Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation.  14:2264-2275. 2019
  • A single reactive noncanonical amino acid is able to dramatically stabilize protein structure.  14:1150-1153. 2019
  • Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686.  14:1174-1182. 2019
  • PF-06651600, a dual JAK3/TEC family kinase inhibitor.  14:1235-1242. 2019
  • A nonaggregating heptamethine cyanine for building brighter labeled biomolecules.  14:934-940. 2019
  • Unique polypharmacology nuclear receptor modulator blocks inflammatory signaling pathways.  14:1051-1062. 2019
  • Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing.  14:784-795. 2019
  • Exploiting CD22 to selectively tolerize autoantibody producing B-cells in rheumatoid arthritis.  14:644-654. 2019
  • Global portrait of protein targets of metabolites of the neurotoxic compound BIA 10-2474.  14:192-197. 2019
  • Responsible peer review.  13:3217-3218. 2018
  • Precise small molecule degradation of a noncoding RNA identifies cellular binding sites and modulates an oncogenic phenotype.  13:3065-3071. 2018
  • A chemical biology approach to model pontocerebellar hypoplasia type 1B (PCH1B).  13:3000-3010. 2018
  • A commensal dipeptidyl aminopeptidase with specificity for N-terminal glycine degrades human-produced antimicrobial peptides in vitro.  13:2513-2521. 2018
  • Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway.  13:2728-2738. 2018
  • Probing the flexibility of an iterative modular polyketide synthase with non-native substrates in vitro.  13:2261-2268. 2018
  • Antitumor humoral and T cell responses by mucin-1 conjugates of bacteriophage Qβ in wild-type mice.  13:1668-1676. 2018
  • Chemical probe to identify the cellular targets of the reactive lipid metabolite 2-trans-hexadecenal.  13:1130-1136. 2018
  • Mechanism of action of the cytotoxic asmarine alkaloids.  13:1299-1306. 2018
  • Playing with the molecules of life.  13:854-870. 2018
  • Structural and functional studies of a pyran synthase domain from a trans-acyltransferase assembly line.  13:975-983. 2018
  • Site-specific incorporation of a thioester containing amino acid into proteins.  13:578-581. 2018
  • Rheostatic control of Cas9-mediated DNA double strand break (DSB) generation and genome editing.  13:438-442. 2018
  • ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II Exhibiting Antiflaviviral Activity.  13:60-65. 2018
  • Large scale mutational and kinetic analysis of a self-hydrolyzing deoxyribozyme.  12:2940-2945. 2017
  • Profiling of protein O-GIcNAcylation in murine CD8(+) effector- and memory-like T cells.  12:3031-3038. 2017
  • Discovery of a distinct chemical and mechanistic class of allosteric HIV-1 integrase inhibitors with antiretroviral activity.  12:2858-2865. 2017
  • Targeted disruption of Myc-Max oncoprotein complex by a small molecule.  12:2715-2719. 2017
  • Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.  12:2671-2681. 2017
  • Linking high-throughput screens to identify MoAs and novel inhibitors of Mycobacterium tuberculosis dihydrofolate reductase.  12:2448-2456. 2017
  • Ventromorphins: a new class of small molecule activators of the canonical BMP signaling pathway.  12:2436-2447. 2017
  • Quantitative chemical proteomic profiling of the in vivo targets of reactive drug metabolites.  12:2040-2050. 2017
  • P450-mediated non-natural cyclopropanation of dehydroalanine-containing thiopeptides.  12:1726-1731. 2017
  • Substrate profiling and high resolution co-complex crystal structure of a secreted C11 protease conserved across commensal bacteria.  12:1556-1565. 2017
  • Halogen-π interactions in the cytochrome P450 active site: Structural insights into human CYP2B6 substrate selectivity.  12:1204-1210. 2017
  • Chemoproteomic screening of covalent ligands reveals UBA5 as a novel pancreatic cancer target.  12:899-904. 2017
  • Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor.  12:969-978. 2017
  • Exploring the structural compliancy versus specificity of the estrogen receptor uUsing isomeric three-dimensional ligands.  12:494-503. 2017
  • Global N-glycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry.  12:357-361. 2017
  • Development of 5N-bicalutamide, a high-affinity reversible covalent antiandrogen.  12:2934-2939. 2017
  • Tools for studying glycans: Recent advances in chemoenzymatic glycan labeling.  12:611-621. 2017
  • An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life.  12:36-40. 2017
  • An effective bacterial fucosidase for glycoprotein remodeling.  12:63-72. 2017
  • High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections.  12:234-243. 2017
  • Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry.  12:153-162. 2017
  • Observing biosynthetic activity utilizing next generation sequencing and the DNA linked enzyme coupled assay.  12:191-199. 2017
  • Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition.  11:3442-3451. 2016
  • Phenyl glycolipids with different glycosyl groups exhibit marked differences in murine and human iNKT cell activation.  11:3431-3441. 2016
  • Challenges in targeting a basic helix-loop-helix transcription factor with hydrocarbon-stapled peptides.  11:3146-3153. 2016
  • Rational design of dual agonist-antibody fusions as long-acting therapeutic hormones.  11:2991-2995. 2016
  • Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors.  11:3214-3225. 2016
  • Selectivity in small molecule splicing modulation.  11:2716-2723. 2016
  • Discovery of a selective covalent inhibitor of lysophospholipase-like 1 (LYPLAL1) as a tool to evaluate the role of this serine hydrolase in metabolism.  11:2529-2540. 2016
  • Small molecule recognition and tools to study modulation of r(CGG)(exp) in fragile X-associated tremor ataxia syndrome.  11:2456-2465. 2016
  • Albumin-oxanorbornadiene conjugates formed ex vivo for the extended circulation of hydrophilic cargo.  11:2320-2327. 2016
  • Development of chemical probes for investigation of salt-inducible kinase function in vivo.  11:2105-2111. 2016
  • Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor Nurr1.  11:1795-1799. 2016
  • Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile.  11:1844-1851. 2016
  • Stabilizing the C(H)2 domain of an antibody by engineering in an enhanced aromatic sequon.  11:1852-1861. 2016
  • Global isotope metabolomics reveals adaptive strategies for nitrogen assimilation.  11:1677-1685. 2016
  • Inforna 2.0: a platform for the sequence-based design of small molecules targeting structured RNAs.  11:1720-1728. 2016
  • Site-specific radiofluorination of biomolecules with 8-[(18)F]-fluorooctanoic acid catalyzed by lipoic acid ligase.  11:1587-1594. 2016
  • FRET characterization of complex conformational changes in a large 165 ribosomal RNA fragment site-specifically labeled using unnatural base pairs.  11:1347-1353. 2016
  • The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.  11:1313-1321. 2016
  • Cutting edge chemical biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland.  11:816-820. 2016
  • Synthetic RORγt agonists enhance protective immunity.  11:1012-1018. 2016
  • Design of potent and proteolytically stable oxyntomodulin analogs.  11:324-328. 2016
  • Small molecule targeting of a microRNA associated with hepatocellular carcinoma.  11:375-380. 2016
  • First-in-class inhibitors of sulfur metabolism with bactericidal activity against non-replicating M. tuberculosis.  11:172-184. 2016
  • SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism.  11:273-283. 2016
  • Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors.  10:2716-2724. 2015
  • Studying a drug-like, RNA-focused small molecule library identifies compounds that inhibit RNA toxicity in myotonic dystrophy.  10:2706-2715. 2015
  • Chemical proteomic platform to identify citrullinated proteins.  10:2520-2528. 2015
  • Mechanism-based post-translational modification and inactivation in terpene synthases.  10:2501-2511. 2015
  • A small molecule inhibits deregulated NRF2 transcriptional activity in cancer.  10:2193-2198. 2015
  • Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II.  10:2405-2414. 2015
  • Small molecule inhibition of miR-544 biogenesis disrupts adaptive responses to hypoxia by modulating ATM-mTOR signaling.  10:2267-2276. 2015
  • A chemical approach for the detection of protein sulfinylation.  10:1825-1830. 2015
  • Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids.  10:1805-1816. 2015
  • Withaferin A analogs that target the AAA plus chaperone p97.  10:1916-1924. 2015
  • Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer.  10:1624-1630. 2015
  • Genetic incorporation of ε-N-2-hydroxyisobutyryl-lysine into recombinant histones.  10:1599-1603. 2015
  • A nonapoptotic role for BAX and BAK in eicosanoid metabolism.  10:1398-1403. 2015
  • Constructing de novo H2O2 signaling via induced protein proximity.  10:1404-1410. 2015
  • Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.  10:1043-1053. 2015
  • Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.  10:925-932. 2015
  • Discovery of native autoantigens via antigen surrogate technology: Application to type 1 diabetes.  10:401-412. 2015
  • Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.  10:364-371. 2015
  • Clickable analogue of cerulenin as chemical probe to explore protein palmitoylation.  10:115-121. 2015
  • Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment.  9:2823-2832. 2014
  • Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor.  9:2787-2795. 2014
  • Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.  9:2833-2842. 2014
  • Discovery of a highly selective caspase-3 substrate for imaging live cells.  9:2199-2203. 2014
  • Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.  9:2194-2198. 2014
  • Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli.  9:1945-1949. 2014
  • Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria.  9:1939-1944. 2014
  • Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology.  9:1645-1646. 2014
  • Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.  9:1894-1905. 2014
  • Protein delivery using Cys2-His2 zinc-finger domains.  9:1662-1667. 2014
  • Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.  9:1273-1283. 2014
  • Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase.  9:1092-1096. 2014
  • A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs.  9:913-921. 2014
  • Role of tRNA orthogonality in an expanded genetic code.  9:874-879. 2014
  • Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides.  9:904-912. 2014
  • Using unnatural amino acid mutagenesis to probe the regulation of PRMT1.  9:649-655. 2014
  • A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions.  9:339-346. 2014
  • Discovery of light-responsive ligands through screening of a light-responsive genetically encoded library.  9:443-450. 2014
  • Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.  9:433-442. 2014
  • Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.  9:538-550. 2014
  • Small molecules for cell reprogramming and heart repair: progress and perspective.  9:34-44. 2014
  • Engineering the polyproline II propensity of a class II major histocompatibility complex ligand peptide.  8:2383-2387. 2013
  • Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators.  8:2404-2411. 2013
  • An antibody CDR3-erythropoietin fusion protein.  8:2117-2121. 2013
  • Features of modularly assembled compounds that impart bioactivity against an RNA target.  8:2312-2321. 2013
  • Novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72.  8:2042-2052. 2013
  • Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor.  8:2024-2032. 2013
  • A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.  8:1747-1754. 2013
  • A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.  8:1747-1754. 2013
  • An expanded genetic code in mammalian cells with a functional quadruplet codon.  8:1640-1645. 2013
  • Discovery of a selective irreversible BMX inhibitor for prostate cancer.  8:1423-1428. 2013
  • On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7.  8:1417-1422. 2013
  • Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.  8:1590-1599. 2013
  • Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.  8:1558-1566. 2013
  • Small molecule mediated proliferation of primary retinal pigment epithelial cells.  8:1407-1411. 2013
  • Boosting immunity to small tumor-associated carbohydrates with bacteriophage Qβ capsids.  8:1253-1262. 2013
  • Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors.  8:1121-1127. 2013
  • Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.  1117-1120. 2013
  • Persulfide reactivity in the detection of protein S-sulfhydration.  8:1110-1116. 2013
  • Small molecule regulation of protein conformation by binding in the flap of HIV protease.  1223-1231. 2013
  • Synthesis and SAR of lehualide B: A marine-derived natural product with potent anti-multiple myeloma activity.  8:1241-1252. 2013
  • Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells.  8:866-870. 2013
  • Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides.  8:832-839. 2013
  • A liver-selective LXR inverse agonist that suppresses hepatic steatosis.  8:559-567. 2013
  • Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.  8:643-650. 2013
  • Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.  8:626-635. 2013
  • Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.  7:2019-2026. 2012
  • Novel selective allosteric and bitopic ligands for the S1P(3) receptor.  7:1975-1983. 2012
  • Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.  7:1984-1993. 2012
  • Manipulating JNK signaling with (-)-zuonin A.  7:1873-1883. 2012
  • Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening.  7:1902-1909. 2012
  • Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.  7:1840-1847. 2012
  • A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.  7:1711-1718. 2012
  • Selective penicillin-binding protein imaging probes reveal substructure in bacterial cell division.  7:1746-1753. 2012
  • Identification of a selective ROR gamma ligand that suppresses T(H)17 cells and stimulates T regulatory cells.  7:1515-1519. 2012
  • Release factor one is nonessential in Escherichia coli.  7:1337-1344. 2012
  • Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code.  7:1462-1470. 2012
  • Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.  7:1184-1189. 2012
  • Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization.  7:1198-1204. 2012
  • Mutasynthesis of a potent anticancer sibiromycin analogue.  7:973-977. 2012
  • Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae.  7:982-987. 2012
  • Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.  7:1040-1048. 2012
  • Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection.  7:1059-1066. 2012
  • Glycan fingerprints: Calculating diversity in glycan libraries.  7:829-834. 2012
  • Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.  7:856-862. 2012
  • Redesign of glycopeptide antibiotics: back to the future.  7:797-804. 2012
  • Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.  7:879-891. 2012
  • Identification of SR2211: a potent synthetic ROR gamma-selective modulator.  7:672-677. 2012
  • 2'-Azido RNA, a versatile tool for chemical biology: synthesis, X-ray structure, siRNA applications, click labeling.  7:581-589. 2012
  • Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.  7:496-505. 2012
  • Engineering transaldolase in Pichia stipitis to improve bioethanol production.  7:481-486. 2012
  • First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.  7:506-517. 2012
  • Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.  7:429-442. 2012
  • Iron-sulfur cluster engineering provides insight into the evolution of substrate specificity among sulfonucleotide reductases.  7:305-314. 2012
  • Recent advances in developing small molecules targeting RNA.  7:73-86. 2012
  • Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.  7:160-165. 2012
  • Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by neurospora crassa.  6:1399-1406. 2011
  • A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor.  6:1214-1222. 2011
  • A chemically induced vaccine strategy for prostate cancer.  6:1223-1231. 2011
  • N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation.  6:1188-1192. 2011
  • Activity-based protein profiling of protein arginine methyltransferase 1.  6:1127-1135. 2011
  • Similarities and differences between two modes of antagonism of the thyroid hormone receptor.  6:1096-1106. 2011
  • Kinase consensus sequences: A breeding ground for crosstalk.  6:881-892. 2011
  • Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1).  6:808-818. 2011
  • Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.  6:618-627. 2011
  • Metabolic labeling of fucosylated glycans in developing zebrafish.  6:547-552. 2011
  • Binding and pK(a) modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.  6:413-418. 2011
  • Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4.  6:466-476. 2011
  • Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor.  6:511-519. 2011
  • Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.  6:218-222. 2011
  • Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.  6:131-134. 2011
  • Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: A new twist on an old molecule.  5:1183-1191. 2010
  • Trapping of hepatitis b virus capsid assembly intermediates by phenylpropenamide assembly accelerators.  5:1125-1136. 2010
  • Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.  5:1029-1034. 2010
  • A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly.  5:943-952. 2010
  • A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.  5:981-993. 2010
  • Identification of a small molecule inhibitor of importin beta mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.  5:967-979. 2010
  • Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors.  5:489-497. 2010
  • Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.  5:195-202. 2010
  • Exploring disease through metabolomics.  5:91-103. 2010
  • Orchestrating redox signaling networks through regulatory cysteine switches.  5:47-62. 2010
  • An orthogonal active site identification system (OASIS) for proteomic profiling of natural product.  4:948-957. 2009
  • Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.  4:958-968. 2009
  • Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.  4:855-864. 2009
  • Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.  4:834-843. 2009
  • Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells.  4:783-799. 2009
  • Regulation of Alkyl-dihydrothiazole-carboxylates (ATCs) by Iron and the Pyochelin Gene Cluster in Pseudomonas aeruginosa.  4:617-623. 2009
  • Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.  4:557-566. 2009
  • Comparative assessment of large-scale proteomic studies of apoptotic proteolysis.  4:401-408. 2009
  • My h-index turns 40: my midlife crisis of impact.  4:311-313. 2009
  • Rational and modular design of potent ligands targeting the rna that causes myotonic dystrophy 2.  4:345-355. 2009
  • Evaluating the potential for halogen bonding in the oxyanion hole of ketosteroid isomerase using unnatural amino acid mutagenesis.  4:269-273. 2009
  • Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron.  4:299-307. 2009
  • Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.  4:199-208. 2009
  • Probing the function of heme distortion in the h-nox family.  3:703-710. 2008
  • Chain dynamics of nascent polypeptides emerging from the ribosome.  3:555-566. 2008
  • Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.  3:486-498. 2008
  • Pathway engineered enzymatic de novo purine nucleotide synthesis.  3:499-511. 2008
  • Discovery of selective aminothiazole aurora kinase inhibitors.  3:180-192. 2008
  • Click imaging of biochemical processes in living systems.  2:775-778. 2007
  • A small molecule microarray platform to select RNA internal loop-ligand interactions.  2:745-754. 2007
  • Exploring the structural diversity of mammalian carbohydrates ("glycospace") by statistical databank analysis.  2:685-691. 2007
  • Closing the gap between interdisciplinary research and disciplinary teaching.  2:518-520. 2007
  • A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.  2:474-478. 2007
  • Structural basis for high-affinity peptide inhibition of human Pin1.  2:320-328. 2007
  • A higher degree of difficulty.  2:197-199. 2007
  • Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation.  2:171-175. 2007
  • The old is new again: asparagine oxidation in calcium-dependent antibiotic biosynthesis.  2:152-154. 2007
  • Balancing teaching and research in obtaining a faculty position at a predominantly undergraduate institution.  2:521-524. 2007
  • Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from Nostoc cyanobionts.  1:766-779. 2006
  • Chemical chaperones and permissive temperatures atter the cellular locatization of Gaucher disease associated glucocerebrosidase variants.  1:235-251. 2006
  • Design and characterization of an active site selective caspase-3 transnitrosating agent.  1:659-665. 2006
  • Histone citrullination by protein arginine deiminase: Is arginine methylation a green light or a roadblock?.  1:433-441. 2006
  • Mechanism-based protein cross-linking probes to investigate carrier protein-mediated biosynthesis.  1:687-691. 2006
  • The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication.  1:359-369. 2006
  • Turning G proteins on and off using peptide ligands.  1:570-574. 2006
  • Utilizing rna aptamers to probe a physiologically important heme-regulated cellular network.  1:515-524. 2006
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Identity

International Standard Serial Number (ISSN)

  • 1554-8929

Electronic International Standard Serial Number (EISSN)

  • 1554-8937

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