Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

A new strategy for improved nicotine vaccines using conformationally constrained haptens

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Meijler, M. M.
  • Matsushita, M.
  • Altobelli, L. J.
  • Wirsching, P.
  • Janda, Kim

publication date

  • June 2003

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.

subject areas

  • Enzyme-Linked Immunosorbent Assay
  • Haptens
  • Hemocyanin
  • Immunoconjugates
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Nicotine
  • Pyridines
  • Vaccines
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja034805t

PubMed ID

  • 12797775
scroll to property group menus

Additional Document Info

start page

  • 7164

end page

  • 7165

volume

  • 125

issue

  • 24

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support