DNA mismatch repair: The hands of a genome guardian

Academic Article

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Overview

authors

• Hopfner, K. P.
• Tainer, John

publication date

• 2000

journal

• Structure  Journal

abstract

• DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

subject areas

• Adenosine Triphosphatases
• Bacterial Proteins
• Base Pair Mismatch
• Computer Simulation
• DNA Repair
• DNA, Bacterial
• DNA-Binding Proteins
• Escherichia coli Proteins
• Genome, Bacterial
• Models, Molecular
• MutS DNA Mismatch-Binding Protein

Identity

International Standard Serial Number (ISSN)

• 0969-2126

Digital Object Identifier (DOI)

• 10.1016/s0969-2126(00)00545-1

PubMed ID

• 11188699

Additional Document Info

start page

• R237

end page

• R241

volume

• 8

issue

• 12