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Polyspecificity of t cell and b cell receptor recognition

Academic Article
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Overview

authors

  • Wucherpfennig, K. W.
  • Allen, P. M.
  • Celada, F.
  • Cohen, I. R.
  • De Boer, R.
  • Garcia, K. C.
  • Goldstein, B.
  • Greenspan, R.
  • Hafler, D.
  • Hodgkin, P.
  • Huseby, E. S.
  • Krakauer, D. C.
  • Nemazee, David
  • Perelson, A. S.
  • Pinilla, C.
  • Strong, R. K.
  • Sercarz, E. E.

publication date

  • August 2007

journal

  • Seminars in Immunology  Journal

abstract

  • A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes.

subject areas

  • Animals
  • Antigen Presentation
  • B-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Humans
  • Ligands
  • Lymphocyte Activation
  • Mice
  • Peptides
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes
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Research

keywords

  • MHC
  • T cell receptor
  • peptide
  • polyspecificity
  • recognition
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Identity

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.simm.2007.02.012

PubMed ID

  • 17398114
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Additional Document Info

start page

  • 216

end page

  • 224

volume

  • 19

issue

  • 4

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