recent publications

• academic article

  • Deryugina, E. I., Zajac, E., Juncker-Jensen, A., Kupriyanova, T. A., Welter, L., Quigley, J. P. Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment Neoplasia  2014 16:771-788  DOI:10.1016/j.neo.2014.08.013  PMID:25379015  PMCID:PMC4212255
  • Zajac, E., Schweighofer, B., Kupriyanova, T. A., Juncker-Jensen, A., Minder, P., Quigley, J. P., Deryugina, E. I. Angiogenic capacity of M1-and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9 Blood  2013 122:4054-4067  DOI:10.1182/blood-2013-05-501494  PMID:24174628  PMCID:PMC3862278
  • Juncker-Jensen, A., Deryugina, E. I., Rimann, I., Zajac, E., Kupriyanova, T. A., Engelholm, L. H., Quigley, J. P. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination Cancer Research  2013 73:4196-4211  DOI:10.1158/0008-5472.can-12-4495  PMID:23687338  PMCID:PMC3754905
  • Bekes, E. M., Deryugina, E. I., Kupriyanova, T. A., Zajac, E., Botkjaer, K. A., Andreasen, P. A., Quigley, J. P. Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells Neoplasia  2011 13:806-821  DOI:10.1593/neo.11704  PMID:21969814  PMCID:PMC3182273
  • Bekes, E. M., Schweighofer, B., Kupriyanova, T. A., Zajac, E., Ardi, V. C., Quigley, J. P., Deryugina, E. I. Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation American Journal of Pathology  2011 179:1455-1470  DOI:10.1016/j.ajpath.2011.05.031  PMID:21741942  PMCID:PMC3157227
  • Conn, E. M., Botkjaer, K. A., Kupriyanova, T. A., Andreasen, P. A., Deryugina, E. I., Quigley, J. P. Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion American Journal of Pathology  2009 175:1638-1652  DOI:10.2353/ajpath.2009.090384  PMID:19729488  PMCID:PMC2751560
  • Subauste, M. C., Kupriyanova, T. A., Conn, E. M., Ardi, V. C., Quigley, J. P., Deryugina, E. I. Evaluation of metastatic and angiogenic potentials of human colon carcinoma cells in chick embryo model systems Clinical & Experimental Metastasis  2009 26:1033-1047  DOI:10.1007/s10585-009-9293-4  PMID:19842048  PMCID:PMC3092735
  • Deryugina, E. I., Conn, E. M., Wortmann, A., Partridge, J. J., Kupriyanova, T. A., Ardi, V. C., Hooper, J. D., Quigley, J. P. Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination Molecular Cancer Research  2009 7:1197-1211  DOI:10.1158/1541-7786.mcr-09-0100  PMID:19671673  PMCID:PMC3068911
  • Partridge, J. J., Madsen, M. A., Ardi, V. C., Papagiannakopoulos, T., Kupriyanova, T. A., Quigley, J. P., Deryugina, E. I. Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis Journal of Biological Chemistry  2007 282:35964-35977  DOI:10.1074/jbc.M705993200  PMID:17895241
  • Ardi, V. C., Kupriyanova, T. A., Deryugina, E. I., Quigley, J. P. Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis Proceedings of the National Academy of Sciences of the United States of America  2007 104:20262-20267  DOI:10.1073/pnas.0706438104  PMID:18077379  PMCID:PMC2154419
  • Zijlstra, A., Seandel, M., Kupriyanova, T. A., Partridge, J. J., Madsen, M. A., Hahn-Dantona, E. A., Quigley, J. P., Deryugina, E. I. Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells Blood  2006 107:317-327  DOI:10.1182/blood-2005-04-1458  PMID:16174763  PMCID:PMC1895349
  • Deryugina, E. I., Zijlstra, A., Partridge, J. J., Kupriyanova, T. A., Madsen, M. A., Papagiannakopoulos, T., Quigley, J. P. Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination Cancer Research  2005 65:10959-10969  DOI:10.1158/0008-5472.can-05-2228  PMID:16322244