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T cell receptor binding kinetics and special role of Vα in T cell development and activation

Academic Article
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Overview

related to degree

  • Yachi, Pia, Ph.D. in Biology, Scripps Research 1998 - 2004

authors

  • Gascoigne, Nicholas
  • Alam, S. M.
  • Lin, C. M.
  • McGuire, M. V.
  • Marine, S.
  • Niederberger, N.
  • Redpath, S.
  • Sim, B. C.
  • Travers, P. J.
  • Yachi, Pia
  • Zal, M. A.
  • Zal, T.

publication date

  • 2000

journal

  • Immunologic Research  Journal

abstract

  • The kinetics of the interaction between T cell receptor (TCR) and major histocompatibility complex (MHC) has an important role in determining thymocyte-positive and -negative selection in the thymus, as well as in T cell activation. The alpha chain of the TCR is the major player in determining how the TCR fits onto the MHC ligand, and thus has a major role in determining whether a T cell develops as class I or class II restricted. In this article, we summarize recent data from our laboratory and others on the role of polymorphism in the Valpha combining site in determining MHC class restriction, and on kinetic parameters in thymocyte selection.

subject areas

  • Animals
  • Humans
  • Kinetics
  • Lymphocyte Activation
  • Major Histocompatibility Complex
  • Polymorphism, Genetic
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocytes
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Research

keywords

  • BIAcore
  • T cell activation
  • T cell development
  • T cell receptor
  • affinity
  • kinetics
  • major histocompatibility complex
  • major histocompatibility complex restriction
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Identity

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/ir:21:2-3:225

PubMed ID

  • 10852121
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Additional Document Info

start page

  • 225

end page

  • 231

volume

  • 21

issue

  • 2-3

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