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Hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice

Academic Article
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Overview

authors

  • Guidotti, Luca
  • Matzke, B.
  • Pasquinelli, C.
  • Shoenberger, J. M.
  • Rogler, C. E.
  • Chisari, Francis

publication date

  • October 1996

journal

  • Journal of Virology  Journal

abstract

  • In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus. Hepatic HBV replication was not affected by overexpression of the envelope or X gene products when these animals were crossed with transgenic mice that express the corresponding viral genes in the hepatocyte. Overexpression of the precore protein, however, eliminated nucleocapsid particles from the cytoplasm of the hepatocytes and abolished HBV replication without affecting the hepatic steady-state content of pregenomic HBV RNA. These observations suggest that the precore protein can exert a dominant negative effect on HBV replication, presumably at the level of nucleocapsid particle maturation or stability, suggesting an important role for this enigmatic viral protein in the HBV life cycle.

subject areas

  • Animals
  • Gene Expression Regulation, Viral
  • Genes, Viral
  • Hepatitis B virus
  • Mice
  • Mice, Transgenic
  • Trans-Activators
  • Viral Core Proteins
  • Viral Envelope Proteins
  • Virus Replication
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Identity

PubMed Central ID

  • PMC190756

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8794350
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Additional Document Info

start page

  • 7056

end page

  • 7061

volume

  • 70

issue

  • 10

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