Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Anxiolytic activity of npy receptor agonists in the conflict test

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Britton, K. T.
  • Southerland, S.
  • VanUden, E.
  • Kirby, D.
  • Rivier, J.
  • Koob, George

publication date

  • July 1997

journal

  • Psychopharmacology  Journal

abstract

  • This investigation examined receptor subtype specificity and possible modulation by GABAa receptor ligands of NPY-induced behavioral responses to stressful stimuli. First, a series of NPY receptor agonists were examined for their potential effects on punished responding in a conflict test modified for incremental shock. NPY, peptide YY (PYY) and NPY Y1 receptor agonists [Leu31,Pro34]-NPY and [Gly6, Glu26,Lys26,Pro34]-NPY produced increases in punished responding in the conflict test. No significant effects on unpunished responding were noted. The pattern of responding was similar to that observed with the benzodiazepine agonist chlordiazepoxide. Neither pancreatic peptide (PP) nor the Y2 agonists NPY13-36 or [Glu2,32,Ala6,Dpr27,Lys28]-NPY significantly altered punished or unpunished responding. Of significance, the atypical Y1 agonist [Cys7,21,Pro34]-NPY produced negligible effects on punished responding, consistent with the presence of a subclass of Y1 receptors. Second, the anxiolytic effects of NPY were subjected to treatments that block actions at the GABAa receptor complex. The increase in punished responding produced by NPY was not altered by administration of the benzodiazepine antagonist flumazenil and only partially blocked by the picrotoxinin receptor ligand isopropylbicyclophosphate (10 and 15 microg/kg). These findings further support the hypothesis that the pharmacologic substrates for the anxiolytic-like actions of NPY may be mediated by the Y1 receptor subtype and suggest that these actions are independent of either the benzodiazepine or picrotoxinin binding sites of the GABA/benzodiazepine receptor complex.

subject areas

  • Animals
  • Anti-Anxiety Agents
  • Behavior, Animal
  • Chlordiazepoxide
  • Dose-Response Relationship, Drug
  • Flumazenil
  • GABA Modulators
  • Male
  • Neuropeptide Y
  • Rats
  • Rats, Wistar
  • Receptors, Neuropeptide Y
scroll to property group menus

Research

keywords

  • GABAa receptor
  • anxiety
  • conflict test
  • neuropeptide Y
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/s002130050313

PubMed ID

  • 9272753
scroll to property group menus

Additional Document Info

start page

  • 6

end page

  • 13

volume

  • 132

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support