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Visualization of macromolecular structures

Academic Article
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Overview

authors

  • O'Donoghue, S. I.
  • Goodsell, David
  • Frangakis, A. S.
  • Jossinet, F.
  • Laskowski, R. A.
  • Nilges, M.
  • Saibil, H. R.
  • Schafferhans, A.
  • Wade, R. C.
  • Westhof, E.
  • Olson, Arthur

publication date

  • March 2010

journal

  • Nature Methods  Journal

abstract

  • Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

subject areas

  • Crystallography, X-Ray
  • Image Processing, Computer-Assisted
  • Internet
  • Macromolecular Substances
  • Models, Molecular
  • Molecular Conformation
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Identity

International Standard Serial Number (ISSN)

  • 1548-7091

Digital Object Identifier (DOI)

  • 10.1038/nmeth.1427

PubMed ID

  • 20195256
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Additional Document Info

start page

  • S42

end page

  • S55

volume

  • 7

issue

  • 3

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