Visualization of macromolecular structures

Academic Article

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Overview

authors

• O'Donoghue, S. I.
• Goodsell, David
• Frangakis, A. S.
• Jossinet, F.
• Laskowski, R. A.
• Nilges, M.
• Saibil, H. R.
• Schafferhans, A.
• Wade, R. C.
• Westhof, E.
• Olson, Arthur

publication date

• March 2010

journal

• Nature Methods  Journal

abstract

• Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

subject areas

• Crystallography, X-Ray
• Image Processing, Computer-Assisted
• Internet
• Macromolecular Substances
• Models, Molecular
• Molecular Conformation

Identity

International Standard Serial Number (ISSN)

• 1548-7091

Digital Object Identifier (DOI)

• 10.1038/nmeth.1427

PubMed ID

• 20195256

Additional Document Info

start page

• S42

end page

• S55

volume

• 7

issue

• 3