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Glycan microarray technologies: Tools to survey host specificity of influenza viruses

Academic Article
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Overview

authors

  • Stevens, J.
  • Blixt, O.
  • Paulson, James
  • Wilson, Ian

publication date

  • November 2006

journal

  • Nature Reviews Microbiology  Journal

abstract

  • New technologies are urgently required for rapid surveillance of the current H5N1 avian influenza A outbreaks to gauge the potential for adaptation of the virus to the human population, a crucial step in the emergence of pandemic influenza virus strains. Owing to the species-specific nature of the interaction between the virus and host glycans, attention has recently focused on novel glycan array technologies that can rapidly assess virus receptor specificity and the potential emergence of human-adapted H5N1 viruses.

subject areas

  • Animals
  • Birds
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Disease Outbreaks
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Humans
  • Influenza A Virus, H5N1 Subtype
  • Influenza in Birds
  • Microarray Analysis
  • Polysaccharides
  • Receptors, Virus
  • Species Specificity
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Identity

International Standard Serial Number (ISSN)

  • 1740-1526

Digital Object Identifier (DOI)

  • 10.1038/nrmicro1530

PubMed ID

  • 17013397
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Additional Document Info

start page

  • 857

end page

  • 864

volume

  • 4

issue

  • 11

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