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Topically applied human recombinant monoclonal igg(1) antibody and its fab and f(ab')(2) fragments protect mice from vaginal transmission of hsv-2

Academic Article
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Overview

authors

  • Zeitlin, L.
  • Whaley, K. J.
  • Sanna, Pietro
  • Moench, T. R.
  • Bastidas, R.
  • DeLogu, A.
  • Williamson, R. A.
  • Burton, Dennis
  • Cone, R. A.

publication date

  • November 1996

journal

  • Virology  Journal

abstract

  • A recombinant human anti-herpes simplex virus monoclonal IgG1, antibody and the corresponding Fab and F(ab')2 fragments were tested for efficacy in preventing vaginal transmission of HSV-2 infection in a well-established mouse model for genital herpes. IgG1, Fab, and F(ab')2 were approximately equally protective; vaginal delivery of 1-5 ng provided approximately 50% protection, and vaginal delivery of 400 ng completely protected mice from genital herpes infection (P < 0.001). These results suggest that topical applications of human monoclonal antibodies may be useful in developing new methods for preventing sexually transmitted disease.

subject areas

  • Administration, Intravaginal
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Cells, Cultured
  • Cytopathogenic Effect, Viral
  • Female
  • Fibroblasts
  • Herpes Genitalis
  • Herpesvirus 2, Human
  • Humans
  • Immunoglobulin Fab Fragments
  • Immunoglobulin G
  • Mice
  • Mice, Inbred C57BL
  • Recombinant Proteins
  • Vagina
  • Virus Shedding
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Identity

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1006/viro.1996.0589

PubMed ID

  • 8918548
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Additional Document Info

start page

  • 213

end page

  • 215

volume

  • 225

issue

  • 1

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