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Peptide synthesis with carbodiimide. III. Racemization

Academic Article
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Overview

authors

  • Rebek Jr., Julius
  • Feitler, D.

publication date

  • 1975

journal

  • International Journal of Peptide and Protein Research  Journal

abstract

  • An isotope dilution assay for racemization during acid couplings is described and applied to carbodiimide-mediated synthesis. Using the coupling of t-BOC-L-phenylalamine with glycine derivatives as a model, racemization in solution falls in the 0.01 to 0.1% range and it is a function of reagent concentrations. A typical coupling using the solid phase method shows 0.03% racemate.

subject areas

  • Carbodiimides
  • Glycine
  • Isomerism
  • Peptides
  • Phenylalanine
  • Radioisotope Dilution Technique
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Identity

International Standard Serial Number (ISSN)

  • 0367-8377

Digital Object Identifier (DOI)

  • 10.1111/j.1399-3011.1975.tb02428.x

PubMed ID

  • 1095505
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Additional Document Info

start page

  • 167

end page

  • 169

volume

  • 7

issue

  • 2

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