Peptide synthesis with carbodiimide. III. Racemization

Academic Article

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Overview

authors

• Rebek Jr., Julius
• Feitler, D.

publication date

• 1975

journal

• International Journal of Peptide and Protein Research  Journal

abstract

• An isotope dilution assay for racemization during acid couplings is described and applied to carbodiimide-mediated synthesis. Using the coupling of t-BOC-L-phenylalamine with glycine derivatives as a model, racemization in solution falls in the 0.01 to 0.1% range and it is a function of reagent concentrations. A typical coupling using the solid phase method shows 0.03% racemate.

subject areas

• Carbodiimides
• Glycine
• Isomerism
• Peptides
• Phenylalanine
• Radioisotope Dilution Technique

Identity

International Standard Serial Number (ISSN)

• 0367-8377

Digital Object Identifier (DOI)

• 10.1111/j.1399-3011.1975.tb02428.x

PubMed ID

• 1095505

Additional Document Info

start page

• 167

end page

• 169

volume

• 7

issue

• 2