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Application of solid-phase clq and raji cell radioimmune assays for detection of circulating immune-complexes in glomerulonephritis

Academic Article
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Overview

authors

  • Tung, K. S. K.
  • Woodroffe, A. J.
  • Ahlin, T. D.
  • Williams, R. C.
  • Wilson, Curtis

publication date

  • 1978

journal

  • Journal of Clinical Investigation  Journal

abstract

  • The C1q solid phase and Raji cell radioimmune assays were used to determine the frequency of detectable circulating immune complexes in patients with glomerulonephritis. In this study, 46% of 56 patients with glomerulonephritis had evidence of circulating immune complexes. More important, circulating immune complexes were associated with some, but not other, types of glomerulonephritis. Thus, immune complexes were detected in lupus glomerulonephritis (9/9 patients), rapidly progressive glomerulonephritis (5/6 patients), and acute nephritis (5/6 patients), but not in IgA-IgG glomerulonephritis (0/7 patients), or membranous glomerulonephritis (0/8 patients). The Raji cell radioimmune assay and the C1q solid phase radioimmune assay showed concordance of 79% in the detection of circulating immune complexes. Serial determinations, in general, showed either persistence of a negative or positive result of conversion of positive to negative.

subject areas

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Antibodies
  • Antigen-Antibody Complex
  • Basement Membrane
  • Child
  • Child, Preschool
  • Complement C1
  • Evaluation Studies as Topic
  • Female
  • Glomerulonephritis
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Lupus Erythematosus, Systemic
  • Lymphocytes
  • Male
  • Middle Aged
  • Radioimmunoassay
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci109115

PubMed ID

  • 659639
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Additional Document Info

start page

  • 61

end page

  • 72

volume

  • 62

issue

  • 1

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