recent publications

• academic article

  • Goswami, D., Callaway, C., Pascal, B. D., Kumar, R., Edwards, D. P., Griffin, P. R. Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry Structure  2014 22:961-973  DOI:10.1016/j.str.2014.04.013  PMID:24909783  PMCID:PMC4393884
  • Hsia, H. E., Kumar, R., Luca, R., Takeda, M., Courchet, J. L., Nakashima, J., Wu, S., Goebbels, S., An, W., Eickholt, B. J., Polleux, F., Rotin, D., et al. Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth Proceedings of the National Academy of Sciences of the United States of America  2014 111:13205-13210  DOI:10.1073/pnas.1400737111  PMID:25157163  PMCID:PMC4246980
  • Bhaskaran, N., van Drogen, F., Ng, H. F., Kumar, R., Ekholm-Reed, S., Peter, M., Sangfelt, O., Reed, S. I. Fbw7alpha and fbw7gamma collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation Molecular and Cellular Biology  2013 33:85-97  DOI:10.1128/mcb.00288-12  PMID:23109421  PMCID:PMC3536299
  • Kumar, R., Moure, C. M., Khan, S. H., Callaway, C., Grimm, S. L., Goswami, D., Griffin, P. R., Edwards, D. P. Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding Journal of Biological Chemistry  2013 288:30285-30299  DOI:10.1074/jbc.M113.491787  PMID:23995840  PMCID:PMC3798494
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Rhodes, N., Heerding, D. A., Duckett, D. R., Eberwein, D. J., Knick, V. B., Lansing, T. J., McConnell, R. T., Gilmer, T. M., Zhang, S. Y., Robell, K., Kahana, J. A., Geske, R. S., et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity Cancer Research  2008 68:2366-2374  DOI:10.1158/0008-5472.can-07-5783  PMID:18381444
  • Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., Bamber, B. A., Bassham, D. C., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy  2008 4:151-175  PMID:18188003  PMCID:PMC2654259
  • Heerding, D. A., Rhodes, N., Leber, J. D., Clark, T. J., Keenan, R. M., Lafrance, L. V., Li, M., Safonov, I. G., Takata, D. T., Venslavsky, J. W., Yamashita, D. S., Choudhry, A. E., et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{ (3s)-3-piperidinylmethyl oxy}-1H-imidazo 4,5-c pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase Journal of Medicinal Chemistry  2008 51:5663-5679  DOI:10.1021/jm8004527  PMID:18800763
  • Kojetin, D. J., Venters, R. A., Kordys, D. R., Thompson, R. J., Kumar, R., Cavanagh, J. Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K Nature Structural & Molecular Biology  2006 13:641-647  DOI:10.1038/nsmb1112d  PMID:16799559
  • Lutz, W., Frank, E. M., Craig, T. A., Thompson, R., Venters, R. A., Kojetin, D., Cavanagh, J., Kumar, R. Calbindin D-28K interacts with Ran-binding protein M: Identification of interacting domains by NMR spectroscopy Biochemical and Biophysical Research Communications  2003 303:1186-1192  DOI:10.1016/s0006-291x(03)00499-6  PMID:12684061