Design and synthesis of dipeptidyl alpha',beta '-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

Academic Article
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publication date

  • October 1998

abstract

  • The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec-1M-1.