Modulation of immunocompetent cells in synovial-fluids by TGF-beta

Academic Article

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Overview

authors

• Kekow, J.
• Gross, W. L.
• Carson, D. A.
• Lotz, Martin

publication date

• April 1991

journal

• Immunitat und Infektion  Journal

abstract

• Mononuclear cells (MNC) in synovial fluids from patients with rheumatoid arthritis and other arthropathies differ clearly from MNC in peripheral blood. Typically the ratio of CD4(+)-/CD8+ lymphocytes is inverted and the response to mitogens/cytokines (IL-1/IL-2) is impaired. Active TGF-beta (transforming growth factor beta) was found to account for these abnormalities, and the major isoform was identified as TGF-beta 2.

subject areas

• Arthritis, Rheumatoid
• CD4-Positive T-Lymphocytes
• Cells, Cultured
• Humans
• Immunity, Cellular
• Leukocytes, Mononuclear
• Lymphocyte Activation
• Synovial Fluid
• T-Lymphocytes
• T-Lymphocytes, Helper-Inducer
• T-Lymphocytes, Regulatory
• Transforming Growth Factor beta

Research

keywords

• CYTOKINES
• IMMUNOSUPPRESSION
• RHEUMATOID ARTHRITIS
• TGF-BETA

Identity

International Standard Serial Number (ISSN)

• 0340-1162

PubMed ID

• 1677345

Additional Document Info

start page

• 60

end page

• 61

volume

• 19

issue

• 2