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Modulation of immunocompetent cells in synovial-fluids by TGF-beta

Academic Article
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Overview

authors

  • Kekow, J.
  • Gross, W. L.
  • Carson, D. A.
  • Lotz, Martin

publication date

  • April 1991

journal

  • Immunitat und Infektion  Journal

abstract

  • Mononuclear cells (MNC) in synovial fluids from patients with rheumatoid arthritis and other arthropathies differ clearly from MNC in peripheral blood. Typically the ratio of CD4(+)-/CD8+ lymphocytes is inverted and the response to mitogens/cytokines (IL-1/IL-2) is impaired. Active TGF-beta (transforming growth factor beta) was found to account for these abnormalities, and the major isoform was identified as TGF-beta 2.

subject areas

  • Arthritis, Rheumatoid
  • CD4-Positive T-Lymphocytes
  • Cells, Cultured
  • Humans
  • Immunity, Cellular
  • Leukocytes, Mononuclear
  • Lymphocyte Activation
  • Synovial Fluid
  • T-Lymphocytes
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Regulatory
  • Transforming Growth Factor beta
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Research

keywords

  • CYTOKINES
  • IMMUNOSUPPRESSION
  • RHEUMATOID ARTHRITIS
  • TGF-BETA
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Identity

International Standard Serial Number (ISSN)

  • 0340-1162

PubMed ID

  • 1677345
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Additional Document Info

start page

  • 60

end page

  • 61

volume

  • 19

issue

  • 2

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