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Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortex

Academic Article
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Overview

authors

  • Touzani, K.
  • Puthanveettil, Sathyanarayanan
  • Kandel, E. R.

publication date

  • March 2007

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Working memory is a temporary memory store where information is held briefly until the appropriate behavior is produced. However, the improvement in the performance of working memory tasks with practice over days points to the existence of a long-lasting component associated with learning strategies that lead to optimal performance. Here we show that the improvement in the performance of mice in a radial maze working memory task required the integrity of the medial prefrontal cortex (mPFC). We further demonstrate that this improvement of working memory performance requires the synthesis of de novo proteins in the mPFC. We suggest that in addition to storing memory briefly the mPFC is also involved in the consolidation and storage of the long-term learning strategies used in working memory.

subject areas

  • Animals
  • Anisomycin
  • Brain Mapping
  • Gene Expression Regulation
  • Learning
  • Male
  • Maze Learning
  • Memory, Short-Term
  • Mice
  • Mice, Inbred C57BL
  • Prefrontal Cortex
  • Proteins
  • Reversal Learning
  • Space Perception
  • Spatial Behavior
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Identity

PubMed Central ID

  • PMC1838463

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0611554104

PubMed ID

  • 17369358
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Additional Document Info

start page

  • 5632

end page

  • 5637

volume

  • 104

issue

  • 13

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