related to degree

• Zhou, Jiacheng, Ph.D. in Chemistry, Scripps Research 1991 - 1996

authors

• Boger, Dale
• Zhou, Jiacheng
• Winter, B.
• Kitos, P. A.

publication date

• December 1995

journal

• Bioorganic & Medicinal Chemistry  Journal

abstract

• The synthesis and evaluation of two key analogs 3 and 4 of the potent antitumor antibiotics deoxybouvardin (1) and RA-VII (2) which contain fundamental modifications in the tetrapeptide subunit are described. Unlike the natural products, these agents 3 and 4, which substitute (Gly)4 and (Gly)3 for the D-Ala-Ala-NMe-Tyr(OMe)-Ala tetrapeptide subunit, adopt conformations in which the central amide in the cycloisodityrosine subunit adopts its inherently preferred trans stereochemistry and both were found to be biologically inactive.

subject areas

• Amino Acid Sequence
• Antibiotics, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Crystallography, X-Ray
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Conformation
• Molecular Sequence Data
• Molecular Structure
• Peptides, Cyclic
• Stereoisomerism

International Standard Serial Number (ISSN)

• 0968-0896

Digital Object Identifier (DOI)

• 10.1016/0968-0896(95)00141-7

PubMed ID

• 8770383

start page

• 1579

end page

• 1593

volume

• 3

issue

• 12