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Crystal structure of mouse cd1: An mhc-like fold with a large hydrophobic binding groove

Academic Article
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Overview

authors

  • Zeng, Z. H.
  • Castano, A. R.
  • Segelke, B. W.
  • Stura, E. A.
  • Peterson, P. A.
  • Wilson, Ian

publication date

  • July 1997

journal

  • Science  Journal

abstract

  • CD1 represents a third lineage of antigen-presenting molecules that are distantly related to major histocompatibility complex (MHC) molecules in the immune system. The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is more closely related to that of MHC class I than to that of MHC class II. The binding groove, although significantly narrower, is substantially larger because of increased depth and it has only two major pockets that are almost completely hydrophobic. The extreme hydrophobicity and shape of the binding site are consistent with observations that human CD1b and CD1c can present mycobacterial cell wall antigens, such as mycolic acid and lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic peptides, but must do so in a very different way from MHC class Ia and class II molecules.

subject areas

  • Animals
  • Antigen Presentation
  • Antigens, CD1
  • Binding Sites
  • Crystallization
  • Crystallography, X-Ray
  • Glycolipids
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Humans
  • Hydrogen Bonding
  • Ligands
  • Lipid Metabolism
  • Lipids
  • Mice
  • Models, Molecular
  • Protein Conformation
  • Protein Folding
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • T-Lymphocyte Subsets
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.277.5324.339

PubMed ID

  • 9219685
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Additional Document Info

start page

  • 339

end page

  • 345

volume

  • 277

issue

  • 5324

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