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Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors

Academic Article
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Overview

authors

  • BaccalĂ , Roberto
  • Witherden, D.
  • Gonzalez-Quintial, R.
  • Dummer, W.
  • Surh, Charles
  • Havran, Wendy
  • Theofilopoulos, Argyrios

publication date

  • April 2005

journal

  • Journal of Immunology  Journal

abstract

  • Among T cell subsets, gamma delta T cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential homing and homeostasis is unknown. To address this question, we studied the resources that control gamma delta T cell homeostasis in secondary lymphoid organs. We found that gamma delta and alpha beta T cells are controlled by partially overlapping resources, because acute homeostatic proliferation of gamma delta T cells was inhibited by an intact alpha beta T cell compartment, and both populations were dependent on IL-7 and IL-15. Significantly, to undergo acute homeostatic proliferation, gamma delta T cells also required their own depletion. Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors.

subject areas

  • Adoptive Transfer
  • Animals
  • Cell Division
  • Homeostasis
  • Interleukin-15
  • Interleukin-7
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Lymphocyte Subsets
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 15814683
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Additional Document Info

start page

  • 4606

end page

  • 4612

volume

  • 174

issue

  • 8

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