recent publications

• academic article

  • Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease tmprss6 is required to sense iron deficiency Science  2008 320:1088-1092  DOI:10.1126/science.1157121  PMID:18451267  PMCID:PMC2430097
  • Rutschmann, S., Hoebe, K., Zalevsky, J., Du, X., Mann, N., Dahiyat, B. I., Steed, P., Beutler, B. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development Journal of Immunology  2006 176:7525-7532  PMID:16751399
  • Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K., Beutler, B. Analysis of the MCMV resistome by ENU mutagenesis Mammalian Genome  2006 17:398-406  DOI:10.1007/s00335-005-0164-2  PMID:16688530
  • Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology  2006 7:156-164  DOI:10.1038/ni1297  PMID:16415873
  • Du, X., Tabeta, K., Mann, N., Crozat, K., Mudd, S., Beutler, B. An essential role for Rxr alpha in the development of Th2 responses European Journal of Immunology  2005 35:3414-3423  DOI:10.1002/eji.200535366  PMID:16259011
  • Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics  2004 166:331-340  DOI:10.1534/genetics.166.1.331  PMID:15020428
  • Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature  2003 424:743-748  DOI:10.1038/nature01889  PMID:12872135
  • Smirnova, I., Mann, N., Dols, A., Derkx, H. H., Hibberd, M. L., Levin, M., Beutler, B. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Proceedings of the National Academy of Sciences of the United States of America  2003 100:6075-6080  DOI:10.1073/pnas.1031605100  PMID:12730365  PMCID:PMC156328
  • Hoebe, K., Du, X., Goode, J., Mann, N., Beutler, B. Lps2: A new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening Journal of Endotoxin Research  2003 9:250-255  DOI:10.1179/096805103225001459  PMID:12935356