Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Three-dimensional structure of gap junctions in fragmented plasma membranes from rat liver

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Sikerwar, S. S.
  • Unwin, Nigel (Peter)

publication date

  • July 1988

journal

  • Biophysical Journal  Journal

abstract

  • Gap junctions forming extensive hexagonal crystalline sheets (unit cell dimension, a = 89 A) were obtained by mild mechanical disruption of plasma membranes from rat liver. The sheets were analysed in three dimensions by negative stain electron microscopy and Fourier image processing. The crystallographic symmetry was shown to approximate to the two-sided plane group p622, indicating that the sheets are composed of two equivalent, oppositely-facing membrane assemblies. The structure of the connexon in these near-to-native junctions is essentially the same as that found in detergent-extracted junctions, the subunits appearing slightly tilted tangential to the central six-fold axis and aligned almost perpendicular to the membrane plane.

subject areas

  • Animals
  • Cell Membrane
  • Intercellular Junctions
  • Liver
  • Microscopy, Electron
  • Models, Structural
  • Rats
  • Rats, Inbred Strains
scroll to property group menus

Identity

PubMed Central ID

  • PMC1330321

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1016/S0006-3495(88)82936-9

PubMed ID

  • 3416023
scroll to property group menus

Additional Document Info

start page

  • 113

end page

  • 119

volume

  • 54

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support