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Regulation of mature t cell homeostasis

Academic Article
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Overview

authors

  • Surh, Charles
  • Sprent, Jonathan

publication date

  • 2005

journal

  • Seminars in Immunology  Journal

abstract

  • The overall size and the composition of the mature T cell pool are regulated by homeostatic mechanisms. Recent work has revealed that homeostatic signals are received from contact with two members of the common gamma chain family of cytokines, IL-7 and IL-15, and from self-MHC/peptide ligands. In essence, homeostasis of naïve T cells is regulated by IL-7 and self-MHC/peptide ligands and homeostasis of memory CD8 cells is controlled by IL-7 and IL-15. All of these signals also appear to be important to a varying degree for homeostasis of memory CD4 cells, but the details are less well understood than for other cell type.

subject areas

  • Animals
  • Cytokines
  • Gene Expression Regulation
  • Homeostasis
  • Humans
  • Immunologic Memory
  • Mice
  • T-Lymphocytes
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Research

keywords

  • T cells
  • cytokines
  • homeostasis
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Identity

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2005.02.007

PubMed ID

  • 15826823
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Additional Document Info

start page

  • 183

end page

  • 191

volume

  • 17

issue

  • 3

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