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Effect of neuropeptides on production of inflammatory cytokines by human-monocytes

Academic Article
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Overview

authors

  • Lotz, Martin
  • Vaughan, J. H.
  • Carson, D. A.

publication date

  • 1988

journal

  • Science  Journal

abstract

  • Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived cytokines, interact in the neural regulation of immunological and inflammatory responses. Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 from human blood monocytes. The neuropeptide effects occur at low doses, are specific as shown by inhibition studies with a substance P antagonist, and require de novo protein synthesis. Since monocyte-derived cytokines regulate multiple cellular functions in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues, these findings identify a potent mechanism for nervous system regulation of host defense responses.

subject areas

  • Cells, Cultured
  • Humans
  • Interleukin-1
  • Interleukin-6
  • Interleukins
  • Kinetics
  • Monocytes
  • Neurokinin A
  • Neuropeptides
  • Protein Biosynthesis
  • Substance P
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2457950

PubMed ID

  • 2457950
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Additional Document Info

start page

  • 1218

end page

  • 1221

volume

  • 241

issue

  • 4870

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